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Volumn 15, Issue 2, 2012, Pages 101-107

Antidiabetic potentials of momordica charantia: Multiple mechanisms behind the effects

Author keywords

a glucosidase; antihyperlipidemic effect; antioxidant activity; blood glucose; diabetes; insulin resistance; Momordica charantia

Indexed keywords

ADIPONECTIN; AGLYCONE; ALKALOID DERIVATIVE; ASCORBIC ACID; CHARANTIN; CUCURBITACIN GLYCOSIDE; CUCURBITANE GLYCOSIDE; DISACCHARIDASE; FATTY ACID; GLUCOSE; GLUCOSIDASE; GLYCOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; KARAVILOSIDE XI; MOMORDICA CHARANTIA EXTRACT; MOMORDICIN; MOMORDIN; NITROGEN; PHENOL; PLANT GLYCOSIDE; POTASSIUM; STEROL; TANNIN; THYROID HORMONE; THYROXINE; TRITERPENOID; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNINDEXED DRUG; VEGETABLE PROTEIN;

EID: 84856295936     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2010.0258     Document Type: Review
Times cited : (95)

References (73)
  • 1
    • 12444296524 scopus 로고    scopus 로고
    • Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
    • DOI 10.1038/sj.ijo.0802853
    • Heilbronn L, Smith SR, Ravussin E: Function of fat cell proliferation, mitochondrial function and fat oxidation results in ec-topic fat storage, insulin resistance and type II diabetes. Int J Obes Relat Metab Disord 2004;28(Suppl 4):S12-S21. (Pubitemid 40143844)
    • (2004) International Journal of Obesity , vol.28 , Issue.SUPPL. 4
    • Heilbronn, L.1    Smith, S.R.2    Ravussin, E.3
  • 2
    • 34547896985 scopus 로고    scopus 로고
    • Dyslipidaemia in diabetic patients: Time for a rethink
    • DOI 10.1111/j.1463-1326.2006.00642.x
    • Shepherd J: Dyslipidaemia in diabetic patients: time for a rethink. Diabetes Obes Metab 2007;9:609-616. (Pubitemid 47261843)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.5 , pp. 609-616
    • Shepherd, J.1
  • 3
    • 34347385457 scopus 로고    scopus 로고
    • Atherosclerosis in diabetes and insulin resistance
    • DOI 10.1111/j.1463-1326.2006.00620.x
    • Reusch JE, Draznin BB: Atherosclerosis in diabetes and insulin resistance. Diabetes Obes Metab 2007;9:455-463. (Pubitemid 47022828)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.4 , pp. 455-463
    • Reusch, J.E.-B.1    Draznin, B.B.2
  • 5
    • 2942538292 scopus 로고    scopus 로고
    • Pharmacological actions and potential uses of Momordica charantia: A review
    • DOI 10.1016/j.jep.2004.03.035, PII S037887410400159X
    • Grover JK, Yadav SP: Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol 2004;93:123-132. (Pubitemid 38739282)
    • (2004) Journal of Ethnopharmacology , vol.93 , Issue.1 , pp. 123-132
    • Grover, J.K.1    Yadav, S.P.2
  • 6
    • 20044383440 scopus 로고    scopus 로고
    • Antioxidant properties of Momordica Charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats
    • Sathishekar D, Subramanian S: Antioxidant properties of Mo-mordica charantia (bitter gourd) seeds on streptozotocin induced diabetic rats. Asia Pac J Clin Nutr 2005;14:153-158. (Pubitemid 40769784)
    • (2005) Asia Pacific Journal of Clinical Nutrition , vol.14 , Issue.2 , pp. 153-158
    • Sathishsekar, D.1    Subramanian, S.2
  • 8
    • 77953789968 scopus 로고
    • Ngtb, yeung hw: Screening of trichosanthes kirilowi, momordica charantia and cucurbita maxima for compound with antilipolytic activity
    • Wong CM, NGTB, Yeung HW: Screening of Trichosanthes kirilowi, Momordica charantia and Cucurbita maxima for compound with antilipolytic activity. J Ethnopharmacol 1985;13: 312-332.
    • (1985) J Ethnopharmacol , vol.13 , pp. 312-332
    • Wong, C.M.1
  • 9
    • 1842418813 scopus 로고    scopus 로고
    • Phytochemical determination and extraction of momordica charantia fruit and its hypoglycemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM)
    • Tongia A, Tongia SK, Mangala D: Phytochemical determination and extraction of Momordica charantia fruit and its hypoglyce-mic potentiation of oral hypoglycemic drugs in diabetes mellitus. Indian J Physiol Pharmacol 2004;48:241-244. (Pubitemid 38436928)
    • (2004) Indian Journal of Physiology and Pharmacology , vol.48 , Issue.2 , pp. 241-244
    • Tongia, A.1    Tongia, S.K.2    Dave, M.3
  • 13
    • 34447646843 scopus 로고    scopus 로고
    • Evaluation of some important chemical constituents of momordica charantia cultivated in hofuf, saudi arabia
    • Assubaie NF, El-Garawany MM: Evaluation of some important chemical constituents of Momordica charantia cultivated in Hofuf, Saudi Arabia. J Biol Sci 2004;4:628-630.
    • (2004) J Biol Sci , vol.4 , pp. 628-630
    • Assubaie, N.F.1    El-Garawany, M.M.2
  • 14
    • 0019458686 scopus 로고
    • Effect of Momordica charantia on blood glucose level of normal and alloxan-diabetic rabbits
    • Akhtar MS, Athar MA, Yaqub M: Effect of Momordica char-antia on blood glucose level of normal and alloxan-diabetic rabbits. Planta Med 1981;42:205-212. (Pubitemid 11007849)
    • (1981) Planta Medica , vol.42 , Issue.3 , pp. 205-212
    • Akhtar, M.S.1    Athar, M.A.2    Yaqub, M.3
  • 15
    • 0019409153 scopus 로고
    • Improvement in glucose tolerance due to Momordica charantia (karela)
    • Leatherdale BA, Panesar RK, Atkins TW, Bailey CJ, Bignell AH: Improvement in glucose tolerance due to Momordica charantia (karela). Br Med J (Clin Res Ed) 1981;282:1823-1824. (Pubitemid 11047735)
    • (1981) British Medical Journal , vol.282 , Issue.6279 , pp. 1823-1824
    • Leatherdale, B.A.1    Panesar, R.K.2    Singh, G.3
  • 16
    • 0026620964 scopus 로고
    • Hypoglycemic effects of Siamese Momordica charantia and Phyllanthus urinaria extracts in streptozotocin-induced diabetic rats (the 1st report)
    • Higashino H, Suzuki A, Tanaka Y, Pootakham K: Hypogly-cemic effects of Siamese Momordica charantia and Phyllanthus urinaria extracts in streptozotocin-induced diabetic rats (the 1st report). Nippon Yakurigaku Zasshi 1992;100:415-421. (Pubitemid 23010885)
    • (1992) Folia Pharmacologica Japonica , vol.100 , Issue.5 , pp. 415-421
    • Higashino, H.1    Suzuki, A.2    Tanaka, Y.3    Pootakham, K.4
  • 17
    • 0030012399 scopus 로고    scopus 로고
    • Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes
    • DOI 10.1006/phrs.1996.0001
    • Sarkar S, Pranav M, Marita R: Demonstration of the hypogly-cemic action of Momordica charantia in a validated animal model of diabetes. Pharmacol Res 1996;33:1-4. (Pubitemid 26229602)
    • (1996) Pharmacological Research , vol.33 , Issue.1 , pp. 1-4
    • Sarkar, S.1    Pranava, M.2    Marita, R.A.3
  • 18
    • 0025011820 scopus 로고
    • Hypoglycaemic effect of Momordica charantia extracts
    • Day C, Cartwright T, Provost J, Bailey CJ: Hypoglycaemic effect of Momordica charantia extracts. Planta Med 1990;56: 426-429. (Pubitemid 20347576)
    • (1990) Planta Medica , vol.56 , Issue.5 , pp. 426-429
    • Day, C.1    Cartwright, T.2    Provost, J.3    Bailey, C.J.4
  • 20
    • 11144244889 scopus 로고    scopus 로고
    • Assessment of thyrogenic responses of m. Charantia
    • Chaturvedi P, Akala H: Assessment of thyrogenic responses of M. charantia. J Appl Zool Res 2003;14:193-197.
    • (2003) J Appl Zool Res , vol.14 , pp. 193-197
    • Chaturvedi, P.1    Akala, H.2
  • 21
    • 48349123776 scopus 로고    scopus 로고
    • Mo-mordica charantia (bitter melon) reduces plasma apolipoprotein b-100 and increases hepatic insulin receptor substrate and phos-phoinositide-3 kinase interactions
    • Nerurkar PV, Lee YK, Motosue M, Adeli K, Nerurkar VR: Mo-mordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phos-phoinositide-3 kinase interactions. Br J Nutr 2008;5:1-9.
    • (2008) Br J Nutr , vol.5 , pp. 1-9
    • Nerurkar, P.V.1    Lee, Y.K.2    Motosue, M.3    Adeli, K.4    Nerurkar, V.R.5
  • 22
    • 0024315811 scopus 로고
    • Effects of long term feeding of acetone extract of Momordica charantia (whole fruit powder) on alloxan diabetic albino rats
    • Singh N, Tyagi SD, Agarwal SC: Effects of long term feeding of acetone extract of Momordica charantia (whole fruit powder) on alloxan diabetic albino rats. Indian J Physiol Pharmacol 1989; 33:97-100. (Pubitemid 19200419)
    • (1989) Indian Journal of Physiology and Pharmacology , vol.33 , Issue.2 , pp. 97-100
    • Singh, N.1    Tyagi, S.D.2    Agarwal, S.C.3
  • 23
    • 33846181646 scopus 로고    scopus 로고
    • Hypoglycaemic and hypotensive effects of Momordica charantia Linn (Cucurbitaceae) whole-plant aqueous extract in rats
    • Ojewole JA, Adewole SO, Olayiwola G: Hypoglycaemic and hypotensive effects of Momordica charantia Linn (Cucurbitaceae) whole-plant aqueous extract in rats. Cardiovasc J S Afr 2006;17:227-232. (Pubitemid 46089124)
    • (2006) Cardiovascular Journal of South Africa , vol.17 , Issue.5 , pp. 227-232
    • Ojewole, J.A.O.1    Adewole, S.O.2    Olayiwola, G.3
  • 24
    • 0035018779 scopus 로고    scopus 로고
    • Treatment with extracts of Momordica charantia and Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats
    • DOI 10.1016/S0378-8741(01)00218-5, PII S0378874101002185
    • Vikrant V, Grover JK, Tendon N, Rathi SS, Gupta N: Treatment with extracts of Momordica charantia and Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats. J Ethnopharmacol 2001;76:139-143. (Pubitemid 32487619)
    • (2001) Journal of Ethnopharmacology , vol.76 , Issue.2 , pp. 139-143
    • Vikrant, V.1    Grover, J.K.2    Tandon, N.3    Rathi, S.S.4    Gupta, N.5
  • 25
    • 0033107711 scopus 로고    scopus 로고
    • Effect of momordica char-antia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients
    • Ahmad N, Hassan MR, Haldar H: Effect of Momordica char-antia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients. Bangladesh Med Res Coun Bull 1999;25:11-13.
    • (1999) Bangladesh Med Res Coun Bull , vol.25 , pp. 11-13
    • Ahmad, N.1    Hassan, M.R.2    Haldar, H.3
  • 28
    • 11144233279 scopus 로고    scopus 로고
    • Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats
    • DOI 10.1002/ptr.1589
    • Chaturvedi P, George S, Miliganyo M, Tripathi YB: Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats. Phytother Res 2004;18:954-956. (Pubitemid 40052780)
    • (2004) Phytotherapy Research , vol.18 , Issue.11 , pp. 954-956
    • Chaturvedi, P.1    George, S.2    Milinganyo, M.3    Tripathi, Y.B.4
  • 29
    • 0034284704 scopus 로고    scopus 로고
    • Effects of momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets
    • Jayasooriya AP, Sakono M, Yukizaki C, Rawano M, Yamamoto K, Fukuda N: Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. J Ethnopharma-col 2000;72:331-336.
    • (2000) J Ethnopharma-col , vol.72 , pp. 331-336
    • Jayasooriya, A.P.1    Sakono, M.2    Yukizaki, C.3    Rawano, M.4    Yamamoto, K.5    Fukuda, N.6
  • 30
    • 27744553086 scopus 로고    scopus 로고
    • Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet
    • Chaturvedi P: Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet. Br J Biomed Sci 2005;62: 124-126. (Pubitemid 41603067)
    • (2005) British Journal of Biomedical Science , vol.62 , Issue.3 , pp. 124-126
    • Chaturvedi, P.1
  • 32
    • 13444277207 scopus 로고    scopus 로고
    • Momordica charantia extracts inhibit uptake of monosaccharide and amino acid across rat everted gut sacs in-vitro
    • DOI 10.1248/bpb.27.216
    • Mahmoodally MF, Gurib-Fakin A, Subratty AH: Momordica charantia extracts inhibit uptake of monosaccharides and amino acids across rat everted gut sacs in vitro. Biol Pharm Bull 2004; 27:216-218. (Pubitemid 41694701)
    • (2004) Biological and Pharmaceutical Bulletin , vol.27 , Issue.2 , pp. 216-218
    • Mahomoodally, M.F.1    Fakim, A.-G.2    Subratty, A.H.3
  • 33
    • 3442899940 scopus 로고    scopus 로고
    • Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat
    • DOI 10.1023/B:MCBI.0000028738.95518.90
    • Ahmad I, Adeghate E, Cuminmgs E, Sharma AK, Singh J: Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin induced diabetes mellitus in rats. Mol Cell Biochem 2004;261:63-70. (Pubitemid 39004517)
    • (2004) Molecular and Cellular Biochemistry , vol.261 , Issue.1 , pp. 63-70
    • Ahmed, I.1    Adeghate, E.2    Cummings, E.3    Sharma, A.K.4    Singh, J.5
  • 34
    • 0012459549 scopus 로고
    • Glucose absorption in relation to ATP content of the small-intestine mucosa in the dog
    • Varro V, Jung I, Szarvas F, Csernay L: Glucose absorption in relation to ATP content of the small-intestine mucosa in the dog. Dig Dis Sci 1965;10:178-182.
    • (1965) Dig Dis Sci , vol.10 , pp. 178-182
    • Varro, V.1    Jung, I.2    Szarvas, F.3    Csernay, L.4
  • 35
    • 33847157168 scopus 로고    scopus 로고
    • Effect of exogenous ATP on Momordica charantia Linn. (Cucurbitaceae) induced inhibition of d-glucose, l-tyrosine and fluid transport across rat everted intestinal sacs in vitro
    • DOI 10.1016/j.jep.2006.09.020, PII S0378874106004703
    • Mahmoodally MF, Gurib-Fakin A, Subratty AH: Effects of exogenous ATP on Momordica charantia Linn (Cucurbitaceae) induced inhibition of d-glucose, l-tyrosine and fluid transport across rat everted intestinal sacs in vitro. J Ethnopharmacol 2007;110:257-263. (Pubitemid 46283659)
    • (2007) Journal of Ethnopharmacology , vol.110 , Issue.2 , pp. 257-263
    • Mahomoodally, M.F.1    Gurib-Fakim, A.2    Subratty, A.H.3
  • 37
    • 33646526684 scopus 로고    scopus 로고
    • A-glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice
    • Casirola DM, Ferraris RP: a-Glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice. Metabolism 2006;55:832-841.
    • (2006) Metabolism , vol.55 , pp. 832-841
    • Casirola, D.M.1    Ferraris, R.P.2
  • 38
    • 0033666084 scopus 로고    scopus 로고
    • Beneficial effects of flavonoids from sesmum indicum, embilica officinalis and momordica charantia
    • Anila L, Vijayalakshmi NR: Beneficial effects of flavonoids from Sesmum indicum, Embilica officinalis and Momordica charantia. Phytother Res 2000;14:592-595.
    • (2000) Phytother Res , vol.14 , pp. 592-595
    • Anila, L.1    Vijayalakshmi, N.R.2
  • 39
    • 0036653312 scopus 로고    scopus 로고
    • α-Glucosidase inhibitor from the seeds of balsam pear (Momordica charantia) and the fruit bodies of Grifola frondosa
    • Matsura H, Asakawa C, Kurimoto M, Mizutani J: a-Glucosidase inhibitor from the seeds of balsam peer (Momordica charantia) and the fruit bodies of Grifola fiondosa. Biosci Biotechnol Bio-chem 2002;66:1576-1578. (Pubitemid 39246868)
    • (2002) Bioscience, Biotechnology and Biochemistry , vol.66 , Issue.7 , pp. 1576-1578
    • Matsuura, H.1    Asakawa, C.2    Kurimoto, M.3    Mizutani, J.4
  • 40
    • 23944448055 scopus 로고    scopus 로고
    • Bitter gourd (Momordica charantia) modulates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats
    • Kumar Shetty A, Suresh Kumar G, Veeraya Salimath P: Bitter gourd (Momordica charantia) modulates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats. Mol Nutr Food Res 2005;49:791-796.
    • (2005) Mol Nutr Food Res , vol.49 , pp. 791-796
    • Kumar Shetty, A.1    Suresh Kumar, G.2    Veeraya Salimath, P.3
  • 44
    • 33744917512 scopus 로고    scopus 로고
    • Slow acting protein extract from fruit pulp of mo-mordica charantia with insulin secretagogue and insulin mimetic activities
    • Sirintorn YA, Sisrchai A, Cheng Yu Y, Polkit S, Sophon R, Walter HH: Slow acting protein extract from fruit pulp of Mo-mordica charantia with insulin secretagogue and insulin mimetic activities. Biol Pharm Bull 2006;29:1126-1131.
    • (2006) Biol Pharm Bull , vol.29 , pp. 1126-1131
    • Sirintorn, Y.A.1    Sisrchai, A.2    Cheng Yu, Y.3    Polkit, S.4    Sophon, R.5    Walter, H.H.6
  • 45
    • 34247891442 scopus 로고    scopus 로고
    • Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3T3-L1 adipose cells
    • DOI 10.1016/j.jep.2007.02.003, PII S0378874107000682
    • Roffey BW, Atwal AS, Johns T, Kubow S: Water extracts from Momordica charantia increases glucose uptake and adiponectin secretion from adipocytes in 3T3-L1 adipose cells. J Ethno-pharmacol 2007;112:77-84. (Pubitemid 46702417)
    • (2007) Journal of Ethnopharmacology , vol.112 , Issue.1 , pp. 77-84
    • Roffey, B.W.C.1    Atwal, A.S.2    Johns, T.3    Kubow, S.4
  • 48
    • 0035990605 scopus 로고    scopus 로고
    • The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism
    • DOI 10.1002/ptr.842
    • Rathi SS, Grover JK, Vats V: The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytother Res 2002;16:236-243. (Pubitemid 34534949)
    • (2002) Phytotherapy Research , vol.16 , Issue.3 , pp. 236-243
    • Rathi, S.S.1    Grover, J.K.2    Vats, V.3
  • 49
    • 79951740993 scopus 로고    scopus 로고
    • Modulation of pancreatic b-cells in neonatally streptozotocin-induced type-2 diabetic rats by the ethanolic extract of momordica charantia fruit pulp
    • Hafizur RM, Kabir N, Chisti S: Modulation of pancreatic b-cells in neonatally streptozotocin-induced type-2 diabetic rats by the ethanolic extract of Momordica charantia fruit pulp. Nat Prod Res 2011;25:353-367.
    • (2011) Nat Prod Res , vol.25 , pp. 353-367
    • Hafizur, R.M.1    Kabir, N.2    Chisti, S.3
  • 50
    • 35748941961 scopus 로고    scopus 로고
    • An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized momordica charantia fruit extract
    • Nafisa PC, Fernandes, Chkradhar VL, Vandana SP, Suresh RN: An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med 2007;7:29.
    • (2007) BMC Complement Altern Med , vol.7 , pp. 29
    • Fernandes, C.N.P.1    Chkradhar, V.L.2    Vandana, S.P.3    Suresh, R.N.4
  • 51
    • 0027215565 scopus 로고
    • Hypoglycaemic activity of coccinia indica and momordica charantia in diabetic rats: Depression of hepatic gluconeogenic enzymes glucose-6-phospha- tase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase
    • Baizid AS, Liakot A, Rafiqur R: Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of hepatic gluconeogenic enzymes glucose-6-phospha-tase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem J 1993;292:267-270.
    • (1993) Biochem J , vol.292 , pp. 267-270
    • Baizid, A.S.1    Liakot, A.2    Rafiqur, R.3
  • 52
    • 38049123030 scopus 로고    scopus 로고
    • Bitter melon (Momordica charantia) inhibits ad-ipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats
    • Huang HL, Hong YW, Wong YH, Chen YN, Chyuan JH, Huang CJ, Chao PM: Bitter melon (Momordica charantia) inhibits ad-ipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats. Br J Nutr 2008;97:230-239.
    • (2008) Br J Nutr , vol.97 , pp. 230-239
    • Huang, H.L.1    Hong, Y.W.2    Wong, Y.H.3    Chen, Y.N.4    Chyuan, J.H.5    Huang, C.J.6    Chao, P.M.7
  • 53
    • 31544471395 scopus 로고    scopus 로고
    • Reduced adiposity in bitter melon (Momordica charantia)-fed rats is associated with increased lipid oxidation enzyme activities and uncoupling protein expression
    • Laureen LYC, Qixuan C, Adi GGG, Emily KYL, Edmund TSL: Reduced adiposity in bitter melon (Momordica charantia)-fed rats is associated with increased lipid oxidation enzyme activities and uncoupling protein expression. J Nutr 2005;135: 2517-2523.
    • (2005) J Nutr , vol.135 , pp. 2517-2523
    • Laureen, L.Y.C.1    Qixuan, C.2    Adi, G.G.G.3    Emily, K.Y.L.4    Edmund, T.S.L.5
  • 54
    • 0347418244 scopus 로고    scopus 로고
    • Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upre-gulates the expression of the acyl coa oxidase gene in h11ec3 heptoma cells
    • Chao CY, Huang CJ: Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upre-gulates the expression of the acyl CoA oxidase gene in H11EC3 heptoma cells. J Biomed Sci 2003;10:782-791.
    • (2003) J Biomed Sci , vol.10 , pp. 782-791
    • Chao, C.Y.1    Huang, C.J.2
  • 57
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • DOI 10.1074/jbc.271.18.10697
    • HuE, Liang P, Spiegelman BM: Adipo Q is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271: 10697-10703. (Pubitemid 26145805)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.18 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 59
    • 78651228900 scopus 로고    scopus 로고
    • Effects of momordica charantia on pancreatic histopathological changes associated with streptozotocin-induced diabetes in neonatal rats
    • Abdollahi M, Zuki AB, Goh YM, Razaeizadeh A, Noordin MM: Effects of Momordica charantia on pancreatic histopathological changes associated with streptozotocin-induced diabetes in neonatal rats. Histol Histopathol 2011;26:13-21.
    • (2011) Histol Histopathol , vol.26 , pp. 13-21
    • Abdollahi, M.1    Zuki, A.B.2    Goh, Y.M.3    Razaeizadeh, A.4    Noordin, M.M.5
  • 60
    • 39649125427 scopus 로고    scopus 로고
    • Regeneration b-cells in islets of langerhans of pancrease of alloxan diabetic rats by acetone extract of mo-mordica charantia (Linn) (bitter gourd) fruits
    • Singh N, Gupta M: Regeneration B-cells in islets of Langerhans of pancrease of alloxan diabetic rats by acetone extract of Mo-mordica charantia (Linn) (bitter gourd) fruits. Indian J Exp Biol 2007;45:1055-1062.
    • (2007) Indian J Exp Biol , vol.45 , pp. 1055-1062
    • Singh, N.1    Gupta, M.2
  • 61
    • 34047106323 scopus 로고    scopus 로고
    • The reparative effects of Momordica Charantia Linn. extract on HIT-T15 pancreatic β-cells
    • Xiang L, Huang X, Chen L, Rao P, Ke L: The reparative effects of Momordica charantia Linn extract on HIT-T15 pancreatic B-cells. Asia Pacific J Clin Nutr 2007;16:249-252. (Pubitemid 46524609)
    • (2007) Asia Pacific Journal of Clinical Nutrition , vol.16 , Issue.SUPPL. 1 , pp. 249-252
    • Xiang, L.1    Huang, X.2    Chen, L.3    Rao, P.4    Ke, L.5
  • 62
    • 70350450341 scopus 로고    scopus 로고
    • Bitter melon protects against lipid peroxidation caused due to immobilization stress in albino rats
    • Chaturvedi P: Bitter melon protects against lipid peroxidation caused due to immobilization stress in albino rats. Int J Vitamin Nutr Res 2009;79:48-56.
    • (2009) Int J Vitamin Nutr Res , vol.79 , pp. 48-56
    • Chaturvedi, P.1
  • 63
    • 77953750796 scopus 로고    scopus 로고
    • Momordica charantia maintains normal glucose levels and lipid profiles and prevents oxidative stress in diabetic rats subjected to chronic sucrose load
    • Chaturvedi P, George S: Momordica charantia maintains normal glucose levels and lipid profiles and prevents oxidative stress in diabetic rats subjected to chronic sucrose load. J Med Food 2010; 13:520-527.
    • (2010) J Med Food , vol.13 , pp. 520-527
    • Chaturvedi, P.1    George, S.2
  • 64
    • 64549141112 scopus 로고    scopus 로고
    • Momordica charantia extract on insulin resistance and the skeletal muscle glut4 protein in fructose fed rats
    • Shih CC, Lin CH, Lin WL, Wu JB: Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose fed rats. J Ethnopharmacol 2009;123:82-99.
    • (2009) J Ethnopharmacol , vol.123 , pp. 82-99
    • Shih, C.C.1    Lin, C.H.2    Lin, W.L.3    Wu, J.B.4
  • 65
    • 0032792665 scopus 로고    scopus 로고
    • AMP activated protein kinase, a metabolic master switch: Possible role in type 2 diabetes
    • Winder WW, Hardie DG: AMP activated protein kinase, a metabolic master switch: possible role in type 2 diabetes. Am J Physiol 1999;277:1-10.
    • (1999) Am J Physiol , vol.277 , pp. 1-10
    • Winder, W.W.1    Hardie, D.G.2
  • 66
    • 78650032735 scopus 로고    scopus 로고
    • Anti-diabetic effects of bitter gourd extracts in insulin resistant db/db mice
    • Klomann SD, Muellar AS, Pallauf J, Krawinkel MB: Anti-diabetic effects of bitter gourd extracts in insulin resistant db/db mice. Br J Nutr 2010;11:1613-1620.
    • (2010) Br J Nutr , vol.11 , pp. 1613-1620
    • Klomann, S.D.1    Muellar, A.S.2    Pallauf, J.3    Krawinkel, M.B.4
  • 68
    • 40449117390 scopus 로고    scopus 로고
    • Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats
    • DOI 10.1017/S000711450783176X, PII S000711450783176X
    • Sridhar MG, Vinayagamoorthi R, Arul Suyambunathan V, Bobby Z, Selvaraj N: Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr 2008;99:806-812. (Pubitemid 351351634)
    • (2008) British Journal of Nutrition , vol.99 , Issue.4 , pp. 806-812
    • Sridhar, M.G.1    Vinayagamoorthi, R.2    Arul Suyambunathan, V.3    Bobby, Z.4    Selvaraj, N.5
  • 70
    • 0031849916 scopus 로고    scopus 로고
    • Evidence for 5'AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
    • DOI 10.2337/diabetes.47.8.1369
    • Hayashi T, Hirshman MF, Kurth EJ, Winder WW, Goodyear L: Evidence for 5 AMP activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 1998; 47:1369-1373. (Pubitemid 28357021)
    • (1998) Diabetes , vol.47 , Issue.8 , pp. 1369-1373
    • Hayashi, T.1    Hirshman, M.F.2    Kurth, E.J.3    Winder, W.W.4    Goodyear, L.J.5
  • 72
    • 38349063250 scopus 로고    scopus 로고
    • Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo
    • Irrcher I, Walkinsaw DR, Sheehan TE, Hood DA: Thyroid hormone (T3) rapidly activates p38 and AMPK in skeletal muscle in vivo. J Appl Physiol 2008;104:178-185.
    • (2008) J Appl Physiol , vol.104 , pp. 178-185
    • Irrcher, I.1    Walkinsaw, D.R.2    Sheehan, T.E.3    Hood, D.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.