Effect of exogenous ATP on Momordica charantia Linn. (Cucurbitaceae) induced inhibition of d-glucose, l-tyrosine and fluid transport across rat everted intestinal sacs in vitro

Journal of Ethnopharmacology

Volumn 110, Issue 2, 2007, Pages 257-263

  Mahomoodally, M F ^a   Gurib Fakim, A ^a   Subratty, A H ^a  

^a UNIVERSITY OF MAURITIUS   (Mauritius)

Author keywords

ATP; d Glucose; Everted intestinal sacs; l Tyrosine; Momordica charantia; Saponins

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; BICARBONATE; BUFFER; GLUCOSE; LAXATIVE; MOMORDICA CHARANTIA EXTRACT; SAPONIN; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMICROBIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CUCUMBER; FLUID TRANSPORT; GLUCOSE TRANSPORT; HYPERGLYCEMIA; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE CELL; MALE; MOMORDICA CHARANTIA; NONHUMAN; PHYTOCHEMISTRY; POSTPRANDIAL STATE; RAT; SEROSA; SMALL INTESTINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL TRANSPORT; FRUIT; GLUCOSE; HYPERGLYCEMIA; INTESTINAL ABSORPTION; INTESTINES; MALE; MOMORDICA CHARANTIA; PHYTOTHERAPY; PLANT EXTRACTS; RATS; SAPONINS; TYROSINE;

CUCURBITACEAE; MOMORDICA CHARANTIA; RATTUS;

EID: 33847157168     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2006.09.020     Document Type: Article

References (42)

1. Ahmad N., Hassan M.R., Halder, and Bennoor K.S. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients. Bangladesh Medical Research Council Bulletin 25 (1999) 11-13
2. Ahmed I., Adeghate E., Sharma A.K., Pallot D.J., and Singh J. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Diabetes Research Clinical Practitioners 40 (1998) 45-51
3. Aktar M.S., Athar M., and Yaqub M. Effect of Momordica charantia on blood glucose level of normal and alloxan-diabetic rabbits. Planta Medica 42 (1981) 205-212
4. Bronk J.R., and Leese H.J. Changes in the adenine nucleotide content of preparations of the rat small intestine in vitro. Journal of Physiology 235 (1973) 183-190
5. Chaudry I.H., Sayeed M.M., and Baue A.E. Uptake of ATP by liver and kidney in vitro. Canadian Journal Physiology Pharmacology 54 (1976) 742-748
6. Chen Q., Chan L.L.Y., and Li E.T.S. Bitter melon (Momordica charantia) reduces adiposity, lower serum insulin and normalizes glucose tolerance in rats fed a high fat diet. Journal of Nutrition 133 (2003) 1088-1093
7. Che-Yi C., and Ching-Jang H. Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and unregulates the expression of acyl CoA oxidase gene in H4IIEC3 hepatoma cells. Journal of Biomedical Science 10 (2003) 782-791
8. Dubey D.K., Biswas A.R., Bapna J.S., and Pradhan S.C. Hypoglycaemic and antihyperglycaemic effects of Momordica charantia L. seed extracts in albino rats. Fitoterapia 6 (1987) 387-390
9. Gurib-Fakim A., Subratty H., Govinden-Soulange J., and Mahomoodally F. Biological activity from indigenous medicinal plants of Mauritius. Pure Applied Chemistry 77 (2005) 41-51
10. Hediger M.A., and Rhoads D.B. Molecular physiology of sodium-glucose cotransporters. Physiology Reviews 74 (2000) 993-1026
11. Higashino H., Suzuki A., Tanaka Y., and Pootakham K. Hypoglyceamic effects of Siamese Momordica charantia and Phyllanthus urinaria extracts in STZ-induced diabetic rats. Nippon Yakurigaku Zasshi 100 (1991) 415-421
12. Jayasooriya A.P., Sakono M., Yukizaki C., Kawano M., Yamamoto K., and Fukuda N. Effects of Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. Journal of Ethnopharmacology 72 (2000) 236-331
13. Johnson I.T., Jennifer M., Gee K.P., Caroyn C., and Fenwick G.R. Influence of saponins on gut permeability and active nutrient transport in vitro. Journal of Nutrition 116 (1986) 2270-2277
14. Karunanayake E.H., Welihinda J., Sirmane S.R., and Sinnadorai G. Oral hypoglycemic activity of some medicinal plants of Sri Lanka. Journal of Ethnopharmacology 11 (1984) 223-231
15. Khanna P., Jain S.C., Panagariya A., and Dixit V.P. Hypoglycaemic activity of polypeptide-p from a plant source. Journal Natural Products 44 (1981) 648-655
16. Kimura Y., Minami Y., Takuda T., Nakajima S., Takagi S., and Funatsu G. Primary structures of N-linked oligosaccharides of momordin-a, a ribosome-inactivating protein from Momordica charantia seeds. Agricultural Biological Chemistry 55 (1991) 2031-2036
17. Loo D.D., Wright E.M., and Zeuthen T. Water pumps. Reviews of Physiology 542 (2002) 53-60
18. Lowry O.H., Rosenbrough N.J., Farr A.L., and Randall R.J. Protein measurements with the Folin phenol reagent. Journal of Biological Chemistry 193 (1951) 265-275
19. Mahomoodally M.F., Gurib-Fakim A., and Subratty A.H. A kinetic model for in vitro intestinal uptake of l-tyrosine and d(+)-glucose across rat everted gut sacs in the presence of Momordica charantia, a medicinal plant used in traditional medicine against diabetes mellitus. Journal of Cell and Molecular Biology 3 (2004) 39-44
20. Mahomoodally M.F., Gurib-Fakim A., and Subratty A.H. Momordica charantia extract inhibit uptake of monosaccharide and amino acid across rat everted gut sacs in vitro. Biological Pharmaceutical Bulletin 27 (2004) 216-218
21. Mahomoodally M.F., Gurib-Fakim A., and Subratty A.H. Experimental evidence for in vitro fluid transport in the presence of a traditional medicinal fruit extract across rat everted intestinal sacs. Fundamental and Clinical Pharmacology 19 (2005) 87-92
22. Mahomoodally M.F., Gurib-Fakim A., and Subratty A.H. Stimulatory effects of antidesma madagascariense on d-glucose, l-tyrosine, fluid and electrolyte transport across rat everted intestine, comparable to insulin action in vitro. British Journal Biomedial Sciences 63 (2006) 12-17
23. Matsuda H., Li Y., Murakami T., Matsumura N., Yamahara J., and Yoshikawa M. Antidiabetic principle of natural medicines. III. Structure-related inhibitory activity and action mode of oleanolic acid glycosides on hypoglycemic activity. Chemical Pharmaceutical Bulletin 46 (1998) 1399-1403
24. Matsuda H., Morikawa T., Ueda H., and Yoshikawa M. Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. Chemical Pharmaceutical Bulletin 49 (2001) 1368-1371
25. Matsuur H., Asakawa C., Kurimoto M., and Mizutani J. Alpha-glucosidase inhibitor from the seeds of balsam pear (Momordica charantia) and the fruit bodies of Grifola frondosa. Bioscience Biotechnology Biochemistry 66 (2002) 1576-1578
26. +-glucose co-transporter is a molecular water pump. Journal of Physiology 508 (1998) 15-21
27. Monsereenusorn Y., and Glinsukon T. Inhibitory effect of capsaicin on intestinal glucose absorption in vitro. Food Cosmet Toxicology 16 (1978) 469-473
28. Murakami T., Emoto A., Matsuda H., and Yoshikawa M. Medicinal foodstuffs. XXI. Structures of new cucurbitane-type triterpene glycosides, goyaglycosides-a, -b, -c, -d, -e, -f, -g and -h, and new oleanane-type triterpene saponins, goyaglycosides I, II and III, from the fresh fruit of Japanese Momordica charantia L. Chemical Pharmaceutical Bulletin 49 (2001) 54-63
29. Obatomi A.B., Adeniyi K.O., and Isfchei C.O. Effects of malnourishment on intestinal fluid and glucose transport in rats. Acta Physiology Hungaria 82 (1994) 187-193
30. Raman A., and Lau C. Antidiabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine 2 (1996) 349-362
31. Sarkar S., Pranava M., and Marita R. Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes. Pharmacology Research 33 (1996) 1-4
32. Shibib B.A., Khan L.A., and Rahman R. Hypoglyceamic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochemistry Journal 292 (1993) 267-270
33. Subratty A., Mahomoodally F., and Gurib-Fakim A. Bitter Melon: an exotic fruit with medicinal values. Nutrition and Food Science Journal 35 (2005) 143-147
34. +-ATPase. Natural Toxin 1 (1993) 235-240
35. Wahle K.W.J., Armstromg D.G., and Sherratt H.A.S. The metabolism of the small intestine: glycolysis in the mucosal of the small intestine of the sheep. Complementary Biochemistry Physiology 38 (1970) 5-20
36. Welihinda J., Avidson G., Gylte E., Hellman B., and Karlson E. The insulin-releasing activity of the tropical plant Momordica charantia. Acta Biology Medicinal Germany 41 (1981) 1229-1239
37. Welihinda J., and Karunanayake E.H. Extra pancreatic effects of Momordica charantia in rats. Journal of Ethnopharmacology 17 (1986) 247-255
38. Wilson T.H., and Wiseman G. The use of sacs of everted small intestine for the study of transference of substances from the mucosal to the serosal surface. Journal of Physiology 123 (1954) 116-125
39. +/glucose cotransporter (SGLT1). Acta Physiology Scandivia (Suppl) 607 (2002) 201-207
40. Yesilada E., Gurbuz I., and Shibata H.J. Momordica charantia: an overview. Journal of Ethnopharmacology 66 (1999) 289-293
41. Zakelj S., Vadnjal L., and Kristl A. The effects of Clodronate on the intergrity and viability of rat small intestine in vitro-a comparison with EDTA. Biological Pharmaceutical Bulletin 28 (2005) 1249-1253
42. Zeuthen T. Molecular water pumps. Reviews Physiology Biochemistry Pharmacology 41 (2000) 95-151