Antidiabetic effects of bitter gourd extracts in insulin-resistant db/db mice

British Journal of Nutrition

Volumn 104, Issue 11, 2010, Pages 1613-1620

  Klomann, Sandra D ^a   Mueller, Andreas S ^b   Pallauf, Josef ^a   Krawinkel, Michael B ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Bitter gourd; Diabetes; Obesity; Protein tyrosine phosphatase 1B

Indexed keywords

ANTIDIABETIC AGENT; GLYCOSYLATED HEMOGLOBIN; LIPID; MOMORDICA CHARANTIA EXTRACT; PROTEIN TYROSINE PHOSPHATASE 1B; SAPONIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; INSULIN RESISTANCE; LIPID PEROXIDATION; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SKELETAL MUSCLE; WEIGHT GAIN;

ADIPOSE TISSUE; ANIMALS; CYTOSOL; DIABETES MELLITUS, TYPE 2; FRUIT; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIPID PEROXIDATION; LIPIDS; MALE; MICE; MICE, KNOCKOUT; MOMORDICA; MUSCLE, SKELETAL; PHYTOTHERAPY; PLANT PREPARATIONS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SAPONINS; WEIGHT GAIN;

MOMORDICA CHARANTIA; MUS;

EID: 78650032735     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510002680     Document Type: Article

References (44)

1. Zimmet P, Alberti KGMM & Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414, 782-787.
2. Cummings E, Hundal HS, Wackerhage H, et al. (2004) Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes. Mol Cell Biochem 261, 99-104.
3. Singh J, Adeghate E, Cummings E, et al. (2004) Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem 261, 63-70.
4. Basch E, Gabardi S & Ulbricht C (2003) Bitter melon (Mormordica charantia): A review of efficacy and safety. Am J Health Syst Pharm 60, 356-359.
5. Krawinkel MB & Keding GB (2006) Bitter gourd (Momordica charantia): A dietary approach to hyperglycemia. Nutr Rev 64, 331-337.
6. Oishi Y, Sakamoto T, Udagawa H, et al. (2007) Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction. Biosci Biotechnol Biochem 71, 735-740.
7. Nerurkar PV, Lee YK, Motosue M, et al. (2008) Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide- 3 kinase interactions. Br J Nutr 100, 751-759.
8. Miura T, Itoh C, Iwamoto N, et al. (2001) Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice. J Nutr Sci Vitaminol (Tokyo) 47, 340-344.
9. Müller AS, Bosse AC, Most E, et al. (2009) Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats. J Nutr Biochem 20, 235-247.
10. Clampit JE, Meuth JL, Smith HAT, et al. (2003) Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells. Biochem Biophys Res Commun 300, 261-267.
11. Ahmad F, Azevedo JL, Cortright R, et al. (1997) Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J Clin Invest 100, 449-458.
12. Mohammad A, Wang J & McNeill JH (2002) Bis(maltolato) oxovanadium(IV) inhibits the activity of PTP1B in Zucker rat skeletal muscle in vivo. Mol Cell Biochem 229, 125-128.
13. Elchebly M, Payette P, Michaliszyn E, et al. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283, 1544-1548.
14. Klaman LD, Boss O, Peroni OD, et al. (2000) Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20, 5479-5489.
15. Gum RJ, Gaede LL, Koterski SL, et al. (2003) Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Diabetes 52, 21-28.
16. Chao CY & Huang CJ (2003) Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. J Biomed Sci 10, 782-791.
17. Chuang CY, Hsu C, Chao CY, et al. (2006) Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARalpha in bitter gourd (Momordica charantia L.). J Biomed Sci 13, 763-772.
18. NRC (National Research Council) (1995) Nutrient Requirements of Laboratory Animals, 4th revised ed. Washington, DC: National Academy Press.
19. Wilmanns von W, Sauer H & Gelinsky P (1969) Beziehung zwischen enzymatischer Formiataktivierung und Erythrozytenlebensdauer (Relationship between enzymatic formate activation and erythrocyte lifespan). Blut XIX, 457-469.
20. Zhu L & Goldstein B (2002) Use of an anaerobic chamber environment for the assay of endogenous cellular proteintyrosine phosphatase activities. Biol Proced Online 4, 1-9.
21. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 2, 248-254.
22. Chomczynski P & Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156-159.
23. Wong SHY, Knight JA, Hopfer SM, et al. (1987) Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 33, 214-220.
24. Khoschsorur GA, Winklhofer-Roob BM, Rabl H, et al. (2000) Evaluation of a sensitive HPLC method for the determination of malondialdehyde, and application of the method to different biological materials. Chromatographia 52, 181-184.
25. Yibchok-Anun S, Adisakwattana S, Yao CY, et al. (2006) Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities. Biol Pharm Bull 29, 1126-1131.
26. Huang HL, Hong YW, Wong YH, et al. (2008) Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats. Br J Nutr 99, 230-239.
27. Roffey BW, Atwal AS, Johns T, et al. (2007) Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3T3-L1 adipose cells. J Ethnopharmacol 112, 77-84.
28. Yibchok-Anun S, Adisakwattana S, Yao CY, et al. (2006) Slow acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and insulinomimetic activities. Biol Pharm Bull 29, 1126-1131.
29. Tan MJ, Ye JM, Turner N, et al. (2008) Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the MAPK pathway. Chem Biol 15, 263-273.
30. Cheng HL, Huang HK, Chang CI, et al. (2008) A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase. J Agric Food Chem 56, 6835-6843.
31. Sridhar MG, Vinayagamoorthi R, Arul Suyambunathan V, et al. (2008) Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr 99, 806-812.
32. Greer JJM, Ware DP & Lefer DJ (2005) Myocardial infarction and heart failure in the db/db diabetic mouse. Am J Physiol Heart Circ Physiol 290, 146-153.
33. Nieto-Vazquez I, Fernández-Veledo S, de Alvaro C, et al. (2007) Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-a-induced insulin resistance. Diabetes 56, 404-413.
34. Ojewole JA, Adewole SO & Olayiwola G (2006) Hypoglycaemic and hypotensive effects of Momordica charantia Linn (Cucurbitaceae) whole-plant aqueous extract in rats. Cardiovasc J South Afr 17, 227-232.
35. Samane S, Noël J, Charrouf Z, et al. (2006) Insulin-sensitizing and anti-proliferative effects of Argania spinosa seed extracts. Evid Based Complement Altern Med 3, 317-327.
36. Mahomoodally MF, Fakim AG & Subratty AH (2004) Momordica charantia extracts inhibit uptake of monosaccharide and amino acid across rat everted gut sacs in-vitro. Biol Pharm Bull 27, 216-218.
37. Denu JM & Tanner KG (1998) Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: Evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37, 5633-5642.
38. Delibegovic M, Bence KK, Mody N, et al. (2007) Improved glucose homeostasis in mice with mucle-specific deletion of protein-tyrosine-phosphatase 1B. Mol Cell Biol 27, 7727-7734.
39. Suzuki R, Arato S, Noguchi R, et al. (2001) Occurrence of conjugated linolenic acid in flesh and seed of bitter gourd. J Oleo Sci 50, 753-758.
40. Dhar P, Chattopadhyay K, Bhattacharyya D, et al. (2007) Antioxidative effect of conjugated linolenic acid in diabetic and non-diabetic blood: An in vitro study. J Oleo Sci 56, 19-24.
41. Njoroge GN & van Luijk MN (2004) Momordica charantia L. (Internet) Record from Protabase [GJH Grubben and OA Denton, editors]. Wageningen: PROTA (Plant Resources of Tropical Africa/Ressources végétales de l'Afrique tropicale). http://database.prota.org/search.htm (accessed 13 April 2010).
42. Sathishsekar D & Subramanian S (2005) Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats. Biol Pharm Bull 28, 978-983.
43. Kumar Shetty A, Suresh Kumar G & Veerayya Salimath P (2005) Bitter gourd (Momordica charantia) modulates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats. Mol Nutr Food Res 49, 791-796.
44. Sekar DS, Sivagnanam K & Subramanian S (2005) Antidiabetic activity of Momordica charantia seeds on streptozotocin induced diabetic rats. Pharmazie 60, 383-387.