Reduced adiposity in bitter melon (Momordica charantia)-fed rats is associated with increased lipid oxidative enzyme activities and uncoupling protein expression

Journal of Nutrition

Volumn 135, Issue 11, 2005, Pages 2517-2523

  Chan, Laureen L Y ^a   Chen, Qixuan ^a   Go, Adi G G ^a   Lam, Emily K Y ^a   Li, Edmund T S ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Acyl CoA dehydrogenase; Adiponectin; Bitter melon; Carnitine palmitoyl transferase I; Uncoupling proteins

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; ADIPONECTIN; CARNITINE PALMITOYLTRANSFERASE; TRIACYLGLYCEROL; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BODY FAT DISTRIBUTION; BROWN ADIPOSE TISSUE; DOSE RESPONSE; ENZYME ACTIVITY; FEEDING; GLUCOSE BLOOD LEVEL; GLYCOGEN MUSCLE LEVEL; INSULIN RESISTANCE; LIPID OXIDATION; MALE; MITOCHONDRION; MOMORDICA CHARANTIA; NONHUMAN; NORADRENALIN BLOOD LEVEL; OBESITY; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; WESTERN BLOTTING;

ANIMALIA; CUCUMIS; MOMORDICA CHARANTIA;

EID: 31544471395     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/135.11.2517     Document Type: Article

References (40)

1. Li S. Ben Cao Gan Mu-1578. Ren Ming Wei Sheng Press, Beijing, 1999.
2. Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol. 2004 Jul;93(1):123-32.
3. Ahmed I, Adeghate E, Cummings E, Sharma AK, Singh J. Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem. 2004 Jun;261(1-2):63-70.
4. Chen Q, Chan LL, Li ET. Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr. 2003;133:1088-93.
5. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm. 2003 Feb 15;60(4):356 -9.
6. Chen Q, Li ET. Reduced adiposity in bitter melon (Momordica charantia) fed rats is associated with lower tissue triglyceride and higher plasma catecholamines. Br J Nutr. 2005;93:747-54.
7. Senanayake GV, Maruyama M, Shibuya K, Sakono M, Fukuda N, Morishita T, Yukizaki C, Kawano M, Ohta H. The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats. J Ethnopharmacol. 2004 Apr;91(2-3):257- 62.
8. Chao CY, Huang CJ. Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. J Biomed Sci. 2003 Nov;10(6 Pt 2):782-91.
9. Nerurkar PV, Pearson L, Efird JT, Adeli K, Theriault AG, Nerurkar VR. Microsomal triglyceride transfer protein gene expression and apoB secretion are inhibited by bitter melon in HepG2 cells. J Nutr. 2005;135:702-6.
10. Himms-Hagen J. Does brown adipose tissue (BAT) have a role in the physiology or treatment of human obesity? Rev Endocr Metab Disord. 2001 Oct;2(4):395-401.
11. Rippe C, Berger K, Mei J, Lowe ME, Erlanson-Albertsson C. Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice. Pancreas. 2003 Mar;26(2):e36-42.
12. Bouillaud F, Ricquier D, Mory G, Thibault J. Increased level of mRNA for the uncoupling protein in brown adipose tissue of rats during thermogenesis induced by cold exposure or norepinephrine infusion. J Biol Chem. 1984 Sep 25;259(18):11583-6.
13. Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS. Adiponectin acts in the brain to decrease body weight. Nat Med. 2004;10:524-9.
14. Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB, Shulman GI. In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. J Biol Chem. 2001 Jun 8;276(23):20240-4.
15. Gong DW, He Y, Karas M, Reitman M. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem. 1997 Sep 26;272(39):24129-32.
16. Bezaire V, Spriet LL, Campbell S, Sabet N, Gerrits M, Bonen A, Harper ME. Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation. FASEB J. 2005 Apr 6;19:977-9.
17. Reeves PG, Nielsen FH, Fahey GC, Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
18. Ahren B, Scheurink AJ. Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice. Eur J Endocrinol. 1998 Oct;139(4):461-7.
19. Cannon B, Lindberg O. Mitochondria from brown adipose tissue: isolation and properties. Methods Enzymol. 1979;55:65-78.
20. Bieber LL, Abraham T, Helmrath T. A rapid spectrophotometric assay for carnitine palmitoyltransferase. Anal Biochem. 1972 Dec;50(2):509 -18.
21. Thorpe C. Acyl-CoA dehydrogenase from pig kidney. Methods Enzymol. 1981;71 Pt C:366-74.
22. Xiao XQ, Grove KL, Grayson BE, Smith MS. Inhibition of uncoupling protein expression during lactation: role of leptin. Endocrinology. 2004;145:830-8.
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680-5.
24. Hui TY, Bernlohr DA. Fatty acid transporters in animal cells. Front Biosci. 1997 May 15;2:d222-31.
25. Makowski L, Hotamisligil GS. Fatty acid binding proteins-the evolutionary crossroads of inflammatory and metabolic responses. J Nutr. 2004 Sep;134(9):2464S-8.
26. Glatz JF, Storch J. Unravelling the significance of cellular fatty acidbinding proteins. Curr Opin Lipidol. 2001 Jun;12(3):267-74.
27. Glatz JF, Schaap FG, Binas B, Bonen A, van der Vusse GJ, Luiken JJ. Cytoplasmic fatty acid-binding protein facilitates fatty acid utilization by skeletal muscle. Acta Physiol Scand. 2003 Aug;178(4):367-71.
28. Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, Cannon B. UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta. 2001 Mar 1;1504(1):82-106.
29. Surwit RS, Wang S, Petro AE, Sanchis D, Raimbault S, Ricquier D, Collins S. Diet-induced changes in uncoupling proteins in obesity-prone and obesityresistant strains of mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4061-5.
30. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999 Jul 9;98(1):115-24.
31. Gomez-Ambrosi J, Fruhbeck G, Martinez JA. Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin. Mol Cell Endocrinol. 2001 May 15;176(1-2):85-90.
32. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20;92(6):829-39.
33. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun. 1997 Jun 9;235(1):79-82.
34. Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature. 2000 Jul 27;406(6794):415-8.
35. Son C, Hosoda K, Ishihara K, Bevilacqua L, Masuzaki H, Fushiki T, Harper ME, Nakao K. Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle. Diabetologia. 2004;47:47-54.
36. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, et al. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000 May 26;275(21):16258-66.
37. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29-33.
38. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941-6.
39. Masaki T, Chiba S, Yasuda T, Tsubone T, Kakuma T, Shimomura I, Funahashi T, Matsuzawa Y, Yoshimatsu H. Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (Ay/a) obese mice. Diabetes. 2003;52:2266-73.
40. Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci U S A. 2001 Feb 1398(4):2005-10.