Antioxidant properties of Momordica Charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats

Asia Pacific Journal of Clinical Nutrition

Volumn 14, Issue 2, 2005, Pages 153-158

  Sathishsekar, Dhanasekar ^a   Subramanian, Sorimuthu ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidant enzymes; Bitter gourd seeds; Diabetes; Momordica charantia; Streptozotocin

Indexed keywords

ANTIOXIDANT; CATALASE; FREE RADICAL; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROPEROXIDE; MOMORDICA CHARANTIA EXTRACT; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HYBRID; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; MOMORDICA CHARANTIA; NONHUMAN; PLANT SEED; PROTECTION; RAT; RISK REDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FREE RADICAL SCAVENGERS; GLUTATHIONE; HYPOGLYCEMIC AGENTS; KIDNEY; LIPID PEROXIDATION; LIPID PEROXIDES; LIVER; MALE; MOMORDICA CHARANTIA; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEEDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS;

ANIMALIA; MOMORDICA CHARANTIA;

EID: 20044383440     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Thornally PJ, McLellan AC, Lo TW. Negative association between reduced glutathione concentration and diabetic complications. Med Sci 1996; 91: 575.
2. Garg MC, Ojha S, Bansal DD. Antioxidant Status of streptozotocin - diabetic rats. Indian J Exp Biol 1996; 34: 264.
3. Andallu B, Varadacharyulu NCh. Antioxidant role of mulberry leaves in streptozotocin-diabetic rats. Clin Chim Acta 2003; 338: 3.
4. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40:405.
5. Jacob RA. The integrated antioxidant system. Nutr Res 1995; 15: 755.
6. Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988; 5: 113.
7. Baynes JW. Mechanistic approach to diabetes. In: Inoannides C, Flatt FR, eds. Reactive oxygen in the aetiology and complications of diabetes. Eths Horwood Limited, 1995; 203:231.
8. Anjali P, Manoj KM. Some comments on diabetes and herbal therapy. Ancient Sci Life 1995; 15: 27.
9. Scartezzini P, Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol 200; 71: 23-43.
10. Sathish Sekar D, Sivagnanam K, Subramanian S. Antidiabetic activity of Momordica charantia seeds on streptozotocin induced diabetic rats. Die Pharmazie 2004; in press
11. Ganguly C, De S, Das S. Prevention of carcinogen-induced mouse skin papilloma by whole fruit aqueous extract of Mormordica charantia. Eur J Cancer Prer 2000; 9: 283.
12. Jayasooriya AP, Sakono M, Yuxizaki C, Kawano M, Yanmoto K, Fukuda N. Effects of Mormordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets. J Ethnopharmacol 2000; 72: 331.
13. Junod A, Lambert AE, Staufacher W, Renold AE. Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest 1969; 48: 2129.
14. Ledoux SP, Woodley SE, Patton NJ, Wilson LG. Mechanism of nitrosourea induced β-cell damage alterations in DNA. Diabetes 1966; 35: 866.
15. Chattopadhyay S, Ramanathan M, Das J, Bhattacharya SK. Animal models in experimental diabetes mellitus. Indian J Exp Biol 1997; 35: 1141.
16. Rajasekaran S, Sivagnanam K, Ravi K and Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetic rats. J Med Food 2004; 7: 61.
17. Sasaki T, Matsy S, Sonae A. Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for the blood glucose estimation. Rinsho Kagaku 1972; 1: 346.
18. Okhawa H, Ohigni N, Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351.
19. Jiang ZY, Hunt JV, Wolff SD. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein. Anal Biochem 1992; 202: 384.
20. Sedlak J, Lindsay RH. Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellmans reagent. Anal Biochem 1968; 25: 293.
21. Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine anion in the autooxidation of epinephrine and a simple assay of superoxide dismutase. J Biol Chem 1972; 247: 3170.
22. Tukahara S, Hamilton BH, Nell JV, Ogura Y, Nishmura ET. Hypocatalasemia, a new genetic carrier state. J Clin Invest 1960; 29: 610.
23. Rotruck JT, Pope LA, Ganther HE, Swanson AB. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588.
24. Habig WH, Pabst MS, Jekpoly WB. Glutathione transferase: a first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130.
25. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin-phenol reagent. J Biol Chem 1951; 193; 265.
26. Ozturia Y, Altan VM, Yildizoglu A. Effect of experimental diabetes and insulin on smooth muscle functions. Pharma Revi 1996; 48: 69.
27. Tomlinson KC, Gardiner SM, Hebden RA and Bennett T. Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol Rev 1992; 44: 103.
28. Andrade-Cetto A, Wiedenfeld H, Revilla Mac, Islay S. Hypoglycemic effect of Equisetum myriochaitum aerial parts on streptozotocin diabetic rats. J Ethnopharmacol 2000; 72: 129.
29. Al-Shamaony L, Al-Khazraji SM, Twaiji HA. Hypoglycemic effect of Artemisia herba alba II. Effect of a valuable extract on some blood parameters in diabetic animals. J Ethnopharmacol 1994; 43: 167.
30. Chen V, Ianuzzo CD. Dosage effect of streptozotocin on rat tissue enzyme activities and glycogen concentration. Can J Physiol Pharmacol 1982; 60: 1251.
31. Padmini K, Chakrabati CH. Effects of bittergourd seed and glibenclamide in streptozotocin induced diabetes mellitus. Indian J Exp Biol 1982; 20: 232.
32. Lery V, Zaltzber H, Ben-Amotz A, Kanter Y, Aviram M. β-carotene affects antioxidant status in non-insulin dependent diabetes mellitus. Pathophysiol 1999; 6: 157.
33. Walsh MF, Pek SB. Possible role of endogenous arachidonic acid metabolites in stimulated release of insulin and glucagons from the isolated, profused rat pancreas. Diabetes 1974; 33: 929.
34. Stanely Mainzen Prince P, Menon VP. Antioxidant action of Tinospora cardifolia root extract in alloxan diabetic rats. Phytothe Res 2001; 15: 213.
35. Nakakimura H, Mizuno K. Studies on lipid peroxidation in biological systems II. Hyperlipoperoxidemia in mice induced by alloxan. Chem Pharmacol Bull 1980; 28: 2207.
36. Winterbourn CC. Concerted antioxidant activity of glutathione and superoxide dismutase. In: Packer L, Fuchs J, eds. Biothiols in health and disease, New York: Marcel Dekker Inc, 1995; 117-134.
37. Loven D, Schedl H, Wilson H, Diekus M. Effect of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocin induced diabetes. Diabetes 1986; 35: 503.
38. Mc Crod JM, Keele BB, Fridovich I. An enzyme based theory of obigate anaerobiosis, the physiological functions of superoxide dismutase. Pro Natl Acad Sci USA 1976; 68: 1024.
39. Sozmen BY, Sozmen B, Delen Y, Onat T. Catalase/ superoxide dismutase (SOD) and catalase/paraoxonase (PON) ratios may implicate poor glycemic control. Ara Med Res 2001; 32: 283.
40. Chance B, Green Stein DS, Roughton RJW. The mechanism of catalase action 1-steady state analysis. Arch Biochem Biophys 1952; 37: 301.
41. Searle AJ, Wilson RL. Glutathione peroxidase: effect of superoxide, hydroxyl and bromine free radicals on enzymic activity. Int J Radi Biol 1980; 37: 213.
42. Yan H, Harding JJ. Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase. Biochem J 1997; 328: 599.
43. Wohaieb SA, Godin DV. Alterations in free radical tissue - defense mechanisms in streptozotocin diabetes in rats: Effect of insulin treatment. Diabetes 1987; 36: 1014.
44. Saxena AK, Srivastava P, Kale RK, Baquer NZ. Impaired antioxidant status in diabetic rat liver: Effect of vanadate. Biochem Pharmacol 1993; 45: 539.
45. Bruce A, Freeman D, James C. Biology of disease. Free radicals and tissue injury. Lab Invest 1982; 47: 412.
46. Hodgson EK and Fridovich I. The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme. Biochemistry 1975; 24: 5294.
47. Anuradha CV and Selvam R. Effect of oral methionine on tissue lipid peroxidation and antioxidants in alloxan induced diabetic rats. J Nutr Biochem 1993; 4: 212.