Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery

International Journal of Molecular Sciences

Volumn 13, Issue 1, 2012, Pages 18-43

  Moodley, Kovanya ^a   Pillay, Viness ^a   Choonara, Yahya E ^a   du Toit, Lisa C ^a   Ndesendo, Valence M K ^a   Kumar, Pradeep ^a   Cooppan, Shivaan ^a   Bawa, Priya ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

"Release modules assemblage"; Controlled drug delivery; Geometrically altered devices; Multilayered tablets; Polymeric materials

Indexed keywords

ATENOLOL; ATORVASTATIN; CELLACEFATE; DILTIAZEM; DISINTEGRATING AGENT; ETHYL CELLULOSE; GLIMEPIRIDE; GUAR GUM; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; METHYLCELLULOSE; METRONIDAZOLE; MICROCRYSTALLINE CELLULOSE; NAPROXEN; NICOTINIC ACID; NIFEDIPINE; POVIDONE; PSEUDOEPHEDRINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE; THEOPHYLLINE; VERAPAMIL; DELAYED RELEASE FORMULATION; DRUG; POLYMER; TABLET;

CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG SOLUBILITY; GEOMETRY; HYDROPHILICITY; HYDROPHOBICITY; OSMOTIC PUMP; POLYMERIZATION; REVIEW; SYSTEM ANALYSIS; TABLET DISINTEGRATION; TABLET FORMULATION; TABLET MATRIX; TABLET POROSITY; TABLET PROPERTY; TABLET THICKNESS; BLOOD; CHEMISTRY; DELAYED RELEASE FORMULATION; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; TABLET;

ADMINISTRATION, ORAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; PHARMACEUTICAL PREPARATIONS; POLYMERS; TABLETS;

EID: 84856244412     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13010018     Document Type: Review

References (105)

1. Deshpande, A.A.; Rhodes, C.T.; Shah, N.S.; Malick, A.W. Controlled-release drug delivery systems for prolonged gastric residence: An overview. Drug Dev. Ind. Pharm. 1996, 22, 531-539.
2. Green, P.G. Iontophoretic delivery of peptide drugs. J. Control. Release 1996, 41, 33-48.
3. Rubinstein, A.; Friedman, M.; Baluom, M.; Tirosh, B. Controlled Release Oral Drug Delivery System. U.S. Patent 7,189,414, 13 March 2007.
4. Abdul, S.; Poddar, S.S. A flexible technology for modified release of drugs: Multi layered tablets. J. Control. Release 2004, 97, 393-405.
5. Yu, D.; Branford-White, C.; Ma, Z.; Zhu, L.M.; Li, X.Y.; Yang, X.L. Novel drug delivery devices for providing linear release profiles fabricated by 3DP. Int. J. Pharm. 2009, 370, 160-166.
6. Varum, F.J.O.; Merchant, H.A.; Basit, A.W. Oral modified-release formulations in motion: The relationship between gastrointestinal transit and drug absorption. Int. J. Pharm. 2010, 395, 1-2, 26-36.
7. Chien, T.W. Fundamentals of Controlled-Release Drug Administration. In Novel Drug Delivery System; Swarbrick, J., Ed.; Marcel Dekker Inc.: New York, NY, USA, 1982; pp. 465-574.
8. Wilding, I.R.; Coupe, A.J.; Davis, S.S. The role of gamma scintigraphy in oral drug delivery. Adv. Drug Deliv. Rev. 1991, 7, 87-117.
9. Fassihi, R.; Yang, L. Controlled Release Drug Delivery System. U.S. Patent 5,783,212, 21 July 1998.
10. Singh, B.N.; Kim, K.H. Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. J. Control. Release 2000, 63, 235-259.
11. Lingam, M.; Ashok, T.; Venkateswarlu, V.; Rao, Y.M. Design and evaluation of a novel matrix type multiple units as biphasic gastroretentive drug delivery systems. AAPS PharmSci. 2006, 9, 1253-1261.
12. Shah, A.C. Design of Oral Sustained Release Drug Delivery Systems: In Vitro/in Vivo Considerations. In Oral Sustained Release Formulation Design and Evaluation; Yacobi, A., Halperin-Walega, E., Eds.; Pergamon: New York, NY, USA, 1988; pp. 35-56.
13. Hardy, I.J.; Windberg-Baarup, A.; Neri, C.; Byway, P.V.; Booth, S.W.; Fitzpatrick, S. Modulation of drug release kinetics from hydroxypropyl methyl cellulose matrix tablets using polyvinyl pyrrolidone. Int. J. Pharm. 2007, 337, 246-253.
14. Landgraf, W.; Li, N.H.; Benson, J.R. New polymer enables near zero order release of drugs. Drug Deliv. Technol. 2005, 5, 48-55.
15. Shahiwala, A.; Misra, A. Pulmonary absorption of liposomal levonorgestrel. AAPS PharmSci. 2004, 5, doi:10.1208/pt050113.
16. Reed, R.C.; Dutta, S.; Liu, W. Once-daily dosing is appropriate for extended-release divalproex over a wide dose range, but not for enteric-coated, delayed-release divalproex: Evidence via computer simulations and implications for epilepsy therapy. Epilepsy Res. 2009, 87, 260-267.
17. Kim, C.J. Coated Tablet With Long Term Parabolic and Zero-Order Release Kinetics. U.S. Patent 6,110,500, 29 August 2000.
18. Sershen, S.; West, J. Implantable, polymeric systems for modulated drug delivery. Adv. Drug Deliv. Rev. 2002, 54, 1225-1235.
19. Vandamme, T.F.; Ellis, K.J. Issues and challenges in developing ruminal drug delivery systems. Adv. Drug Deliv. Rev. 2004, 56, 1415-1436.
20. Ayres, J.W. Coated, Platform-Generating Tablet. U.S. Patent 6,733,784, 11 May 2004.
21. Shivaraj, A.; Selvam, R.P.; Mani, T.T.; Sivakumar, T. Design and evaluation of transdermal drug delivery of ketotifen fumarate. Int. J. Pharm. Biomed. Res. 2010, 1, 42-47.
22. Siegel, S.; Winey, K. Long-Term Delivery Formulations and Methods of Use Thereof. U.S. Pat. Appl. 20080305140, 12 November 2008.
23. Cheng, P.; Chen, M.; Udipi, K. Dry Diazeniumdiolation Methods for Producing Nitric Oxide Releasing Medical Devices. U.S. Pat. Appl. 20100159119, 24 June 2010.
24. Varelas, C.G.; Dixon, D.G.; Steiner, C.A. Zero-order release from biphasic polymer hydrogels. J. Control. Release 1995, 34, 185-192.
25. Qiu, Y.; Chidambaram, N.; Flood, K. Design and evaluation of layered diffusional matrices for zero-order sustained-release. J. Control. Release 1998, 51, 123-130.
26. Pillay, V.; Fassihi, R. Electrolyte-induced compositional heterogeneity: A novel approach for rate-controlled oral drug delivery. J. Pharm. Sci. 1999, 88, 1140-1148.
27. Yang, L.; Fassihi, R. Zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system. J. Pharm. Sci. 2000, 85, 170-173.
28. Gallardo, A.; Rodríguez, G.; Aguilar, M.R.; Fernández, M.; San Román, J. A kinetic model to explain the zero-order release of drugs from ionic polymeric drug conjugates: Application to AMPS-Triflusal-Derived polymeric drugs. Macromolecules 2003, 36, 8876-8880.
29. Andjelić, S.; Yuan, J.; Jamiolkowski, D.D.; Diluccio, R.; Bezwada, R.; Zhang, H.; Mijovic, J. Hydrophilic absorbable copolyester exhibiting zero-order drug release. Pharm. Res. 2006, 23, 821-834.
30. Pryce Lewis, W.E.; Rowe, C.W.; Cima, M.J.; Materna, P.A. System for Manufacturing Controlled Release Dosage Forms, Such as Zero-Order Release Profile Dosage Form Manufactured by Three-Dimensional Printing. U.S. Patent 7,820,201, 26 October 2010.
31. Wang, S.X.; Bao, A.; Phillips, W.T.; Goins, B.; Herrera, S.J.; Santoyo, C.; Miller, F.R.; Otto, R.A. Intraoperative therapy with liposomal drug delivery: Retention and distribution in human head and neck squamous cell carcinoma xenograft model. Int. J. Pharm. 2009, 373, 156-164.
32. Brooke, D.; Walshkuhn, R.J. Zero-order drug delivery system: Theory and preliminary testing. J. Pharm. Sci. 1977, 66, 159-162.
33. Ford, J.L.; Rubenstein, M.H.; McCaul, F.; Hogan, J.E.; Edgar, P.J. Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets. Int. J. Pharm. 1987, 40, 233-234.
34. Sangalli, M.E.; Conte, U.; Gazzaniga, A.; La Manna, A. Inert Monolithic Device with Central Hole for Constant Release. In Proceedings of the International Symposium of Controlled Release Bioactive Materials, Washington, DC, USA, 25-30 July 1993; Academic Press Inc.: New York, NY, USA, 1980; Volume 20, pp. 316-317.
35. Siepmann, J.; Streubel, A.; Peppas, N.A. Understanding and predicting drug delivery from hydrophilic matrix tablets using the "Sequential Layer". Model. Pharm. Res. 2002, 19, 306-314.
36. Chopra, S.K. Drug Delivery Systems Based on Geometric Configuration. In Modified-Release Drug Delivery Technology; Rathbone, M.J., Hadgraft, J., Roberts, M.S., Eds.; Marcel Dekker: New York, NY, USA, 2002; pp. 35-48, doi:10.1201/9780203910337.ch4.
37. Cobby, J.; Mayersohn, M.; Walker, G.C. Influence of shape factors on kinetics of drug release from matrix tablets I: Theoretical. J. Pharm. Sci. 1974, 63, 725-732.
38. Sakamoto, J.H.; van de Ven, A.L.; Godin, B.; Blanco, E.; Serda, R.E.; Grattoni, A.; Ziemys, A.; Bouamrani, A.; Hu, T.; Ranganathan, S.I.; et al. Enabling individualized therapy through nanotechnology. Pharmacol. Res. 2010, 62, 57-89.
39. Cao, X.; Lai, S.; Lee, L.J. Design of a self-regulated drug delivery device. Biomed. Microdevices 2001, 3, 109-118.
40. Efentakis, M.; Politis, S. Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release. Eur. Polym. J. 2006, 42, 1183-1195.
41. Martin del Valle, E.M.; Galan, M.A.; Carbonell, R.G. Drug delivery technologies: The way forward in the new decade. Ind. Eng. Chem. Res. 2009, 48, 2475-2486.
42. Sundy, E.; Danckwerts, M.P. A novel compression-coated doughnut-shaped tablet design for zero-order sustained release. Eur. J. Pharm. Sci. 2004, 22, 477-485.
43. Dash, S.; Murthy, P.N.; Nath, L.; Chowdhury, P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol. Pharm. 2010, 67, 217-223.
44. Conte, U.; Maggi, L.; Colombo, P.; Manna, L. Multilayered hydrophilic matrices as constant release devices. J. Control. Release 1993, 26, 39-47.
45. Kim, C.J. Release kinetics of coated, donut-shaped tablets for water soluble drugs. Eur. J. Pharm. Sci. 1999, 12, 237-242.
46. Survase, S.; Kumar, N. Pulsatile drug delivery: Current scenario. Curr. Res. Info. Pharm. Sci. 2007, 8, 27-33.
47. Losi, E.; Bettini, R.; Santi, P.; Sonvico, F.; Colombo, G.; Lofthus, K.; Colombo, P.; Peppas, N.A. Assemblage of novel release modules for the development of adaptable drug delivery systems. J. Control. Release 2006, 111, 212-218.
48. Gohel, M.C.; Nagori, S.A. A novel colonic drug delivery system of ibuprofen. Asian J. Pharm. 2009, 3, 233-239.
49. Colombo, P.; La Manna, A.; Conte, U. System for the Controlled-Rate Release of Active Substances. U.S. Patent 4,839,177, 13 June 1989.
50. Song, F.; Zhang, L.; Yang, C.; Yan, L. Genipin-crosslinked casein hydrogels for controlled drug delivery. Int. J. Pharm. 2009, 373, 41-47.
51. Herrlich, S.; Ziolek, S.; Hoefemann, H.; Zengerle, R.; Haeberle, S. Adjustable Diffusion Barrier for Controlled Drug Release in Spastic and Pain Therapy. In Proceedings of the 4th European Conference of the International Federation of Medical and Biological Engineering, Antwerp, Belgium, 23-27 November 2008; Springer: New York, NY, USA, 2009, Volume 22, pp. 2368-2371.
52. Mueller, K.F.; Heiber, S.J. Crosslinked, Porous Polymers for Controlled Drug Delivery. U.S. Patent 4,548,990, 22 October 1985.
53. Crotts, G.; Park, T.G. Preparation of porous and nonporous biodegradable polymeric hollow microspheres. J. Control. Release 1995, 35, 91-105.
54. Learoyd, T.P.; Burrows, J.L.; French, E.; Seville, P.C. Sustained delivery by leucine-modified chitosan spray-dried respirable powders. Int. J. Pharm. 2009, 372, 97-104.
55. Naveen, R. Biodegradable polymers in controlled drug delivery. Pharmainfo.net 2009. Available online: http://www.pharmainfo.net/raghanaveen/biodegradable-polymers-controlled-drug-delivery (accessed on 3 May 2010).
56. Heller, J.; Pangburn, S.H.; Penhale, D.W.H. Use of Bioerodible Polymers in Self-Regulated Drug Delivery Systems. In Controlled-Release Technology, Pharmaceutical Applications; Lee, P.I., Good, W.R., Eds.; ACS Symposium Series: Washington, DC, USA, 1987; pp. 172-187.
57. Harland, R.S.; Gazzaniga, A.; Sangalli, M.E.; Colombo, P.; Peppas, N.A. Drug/polymer matrix swelling and dissolution. Pharm. Res. 1998, 5, 488-494.
58. Lee, P.I. Kinetics of drug release from the hydrogel matrices. J. Control. Release 1985, 2, 277-288.
59. Nelson, K.G.; Smith, S.J.; Bennet, R.M. Constant-Release Diffusion Systems: Rate Control by Means of Geometric Configuration. In Controlled-Release Technology, Pharmaceutical Applications; Lee, P.I., Good, W.R., Eds.; ACS Symposium Series: Washington, DC, USA, 1987; pp. 324-340.
60. Peppas, N.A.; Sahlin, J.J. A simple equation for the description of solute release: III. Coupling of diffusion and relaxation. Int. J. Pharm. 1989, 57, 162-172.
61. Narasimhan, B.; Langer, R. Zero-order release of micro and macromolecules from polymeric devices: The role of the burst effect. J. Control. Release 1997, 47, 13-20.
62. Conte, U.; Maggi, L. A flexible technology for the linear, pulsatile and delayed release of drugs allowing for easy accommodation of difficult in vitro targets. J. Control. Release 2000, 64, 263-268.
63. Zerbe, H.G.; Szabo, P. Oral Dosage Formulation. U.S. Pat. Appl. 20060127478, 15 June 2006.
64. Namdeo, B. Barrier layers in multilayered tablets. Express Pharma 2008. Available online: www.expresspharmaonline.com/20080731/research03.shtml (accessed on 24 October 2010).
65. Chidambaram, N.; Porter, W.; Flood, K.; Qui, Y. Formulation and characterisation of new layered diffusional matrices for zero-order sustained release. J. Control. Release 1998, 52, 149-158.
66. Kim, C.J. Controlled release from triple layer, donut-shaped tablets with enteric polymers. AAPS PharmSci. 2005, 6, 429-436.
67. Shionogi Pharma, Inc. Once a day Sular® (Nisoldipine) with Geomatrix® delivery system for the treatment of hypertension. 2008. Available online: http://www.sular.com/html/geomatrix.html (accessed on 24 August 2010).
68. Patel, V.M.; Prajapati, B.G.; Patel, M.M. Formulation, evaluation, and comparison of bilayered and multilayered mucoadhesive buccal devices of propranolol hydrochloride. AAPS PharmSci. 2007, 8, E147-E154.
69. Streubel, A.; Siepmann, J.; Peppas, N.A.; Bodmeier, R. Bimodal drug release achieved with multi-layer matrix tablets: Transport mechanisms and device design. J. Control. Release 2000, 69, 455-468.
70. Efentakis, M.; Peponaki, C. Formulation study and evaluation of matrix and three-layer tablet sustained drug delivery systems based on carbopols with isosorbide mononitrate. AAPS PharmSci. 2008, 9, 917-923.
71. Elan drug technologies. Spheroidal drug absorption system (SODAS®). 2010. Available online: http://www.elandrugtechnologies.com/oral_controlled_release/sodas (accessed on 26 August 2010).
72. Ye, I.M.; Karasulu, H.; Ertan, G. Different geometric shaped hydrogel theophylline tablets: Statistical approach for estimating drug release. Farmaco 2003, 57, 939-945.
73. Hongtao, L.; Xiaochen, G.U. Correlation between drug dissolution and polymer hydration: A study using texture analysis. Int. J. Pharm. 2007, 342, 18-25.
74. Conti, S.; Maggi, L.; Segale, L.; Ochoa Machiste, E.; Conte, U.; Grenier, P.; Vergnault, G. Matrices containing NaCMC and HPMC: 2. Swelling and release mechanism study. Int. J. Pharm. 2007, 333, 143-151.
75. Li, H.; Hardy, R.J.; Gu, X. Effect of drug solubility on polymer hydration and drug dissolution from polyethylene oxide (PEO) matrix tablets. AAPS PharmSci. 2008, 9, 437-443.
76. Barakat, N.S.; Elbagory, I.M.; Almurshedi, A.S. Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components. Drug Deliv. 2009, 16, 57-65.
77. Yang, L.; Johnson, B.; Fassihi, R. Determination of continuous changes in the gel layer thickness of poly(ethylene oxide) and HPMC tablets undergoing hydration: A textural analysis study. Pharm. Res. 1998, 15, 1902-1906.
78. Zerbe, H.G.; Krumme, M. Design Characteristics and Release Properties of a Novel Erosion-Controlled Oral Delivery System. In Modified-Release Drug Delivery Technology; Rathbone, M.J., Hadgraft, J., Roberts, M.S., Eds.; Marcel Dekker: New York, NY, USA, 2002; pp. 59-76, doi:10.1201/9780203910337.ch6.
79. Porter, S.C. Novel drug delivery: Review of current trends with oral solid dosage forms. Am. Pharm. Rev. 2009, 85, 28-35.
80. Doshi, M.M.; Joshi, M.D.; Mehta, B.P. Pharmaceutical Composition for Controlled Drug Delivery System. U.S. Patent 7,157,100, 2 January 2007.
81. Patra, C.N.; Kumar, A.B.; Pandit, H.K.; Singh, S.P.; Devi, M.V. Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride. Acta Pharm. 2007, 57, 479-489.
82. Nirmal, J.; Saisivam, S.; Peddanna, C.; Muralidharan, S.; Godwinkumar, S.; Nagarajan, M. Bilayer tablets of Atorvastatin calcium and Nicotinic acid: Formulation and evaluation. Chem. Pharm. Bull. 2008, 56, 1455-1458.
83. Kim, S.W.; Jun, S.S.; Jo, Y.G.; Koo, J.S.; Jun, Y.S. Combination Formulation with Controlled Release Comprising Metformin and Glimepiride. WIPO Pat. Appl. WO/2008/050987, 2 May 2008.
84. IntelGelx Corp. Innovative Drug Delivery Solutions. 2009. Available online: http://www.intelgenx.com/_assets/pdf/Rodman-Renshaw-Sept-2009.pdf (accessed on 26 August 2010).
85. SkyePharma. A chronotherapy focused-real time oral drug delivery. 2010. Available online: http://www.skyepharma.com/ (accessed on 26 August 2010).
86. Maggi, L.; Shepard, T.; Rochdi, M.; Grenier, P.; Halbeisen, S.; Zimmer, R.; Conte, U. A Simulation Approach for Efficient Development of a Naproxen Geomatrix Quick/Slow Formulation. In Proceedings of the 24th International Symposium on Controlled Release of Bioactive Materials; The controlled release society: Stockholm, Sweden, 1997; pp. 327-328.
87. Desai, S. Multilayer Controlled Release Tablets Containing both Naproxen and Naproxen Sodium Salt. Eur. Patent EP 0656776, 20 March 1996.
88. Iyer, K.; Jha, R.J.; Saoji, D.G. Cardiovascular Therapeutic Combinations. WIPO Pat. Appl. WO/2006/085128, 17 August 2006.
89. Lopes, C.M.; Lobo, J.M.S.; Pinto, J.F.; Costa, P. Compressed mini-tablet as a biphasic delivery system. Int. J. Pharm. 2006, 303, 93-100.
90. Fukui, J.; Uemura, K.; Kobayashi, M. Studies on applicability of press-coated tablets using hydroxypropylcellulose (HPC) in the outer shell for timed-release preparations. J. Control. Release 2000, 68, 215-223.
91. Siahi, M.R.; Barzegar-Jalali, M.; Monajjemzadeh, F.; Ghaffar, I.F.; Azarmi, S. Design and evaluation of 1- and 3-layer matrices of verapamil hydrochloride for sustaining its release. AAPS PharmSci. 2005, 6, 626-632.
92. Krishnaiah, Y.S.R.; Karthikeyan, R.S.; Gouri Sankar, V.; Satyanarayana, V. Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride. J. Control Release 2002, 81, 45-56.
93. Longxiao, L.; Binjie, C. Preparation of monolithic osmotic pump system by coating the indented core tablet. Eur. J. Pharm. Biopharm. 2006, 64, 180-184.
94. Longxiao, L.; Xiangning, X. Preparation of bilayer-core osmotic pump tablet by coating the indented core tablet. Int. J. Pharm. 2008, 352, 225-239.
95. Faour, J.; Mayorga, J. Multi-Layered Osmotic Device. U.S. Reissued Patent RE39069, 18 April 2006.
96. Flanner, H.H.; Mcknight, L.C.; Burnside, B.A. System for Osmotic Delivery of Pharmaceutically Active Agents. U.S. Patent 6,838,093, 4 January 2005.
97. Liu, Q.; Fassihi, R. Zero-order delivery of a highly soluble, low dose drug alfuzosin hydrochloride via gastro-retentive system. Int. J. Pharm. 2008, 348, 27-34.
98. Yang, L.; Eshragh, J.; Fassihi, R. A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: In vitro evaluation. J. Control. Release 1999, 57, 215-222.
99. Danckwerts, M.P. Development of a zero-order release oral compressed tablet with potential for commercial tabletting production. Int. J. Pharm. 1994, 112, 37-45.
100. Guimarães, G.G.; Katsuki, G.I.; Zanardo, N.D.; Ribeiro, D.A.; Cavalcanti, O.A. Evaluation of pectin-HPMC as compression coating. I-A study of the swelling properties of coated tablet. Rev. Bras. Cienc. Farm. 2008, 44, 133-141.
101. Cleave, J.P. Some geometrical considerations concerning the design of tablets. J. Pharm. Pharmacol. 1965, 17, 698-702.
102. Rhine, W.D.; Hsieh, D.S.T.; Langer, R. Polymers for sustained macromolecule release: Procedures to fabricate reproducible delivery systems and control release kinetics. J. Pharm. Sci. 1980, 69, 265-270.
103. Hsieh, D.S.T.; Rhine, W.D.; Langer, R. Zero-order controlled release polymer matrices for micro and macromolecules. J. Pharm. Sci. 1983, 72, 17-22.
104. Kim, C.J. Compressed donut-shaped tablets with zero-order release kinetics. Pharm. Res. 1995, 12, 1045-1048.
105. Cheng, K.; Zhu, J.; Song, X.; Sun, L.; Junhong, Z. Studies of hydroxypropylmethylcellulose donut-shaped tablets. Drug Dev. Ind. Pharm. 1999, 25, 1067-1071.