Effect of drug solubility on polymer hydration and drug dissolution from polyethylene oxide (PEO) matrix tablets

AAPS PharmSciTech

Volumn 9, Issue 2, 2008, Pages 437-443

  Li, Hongtao ^a   Hardy, Robert J ^a   Gu, Xiaochen ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Drug dissolution; Modified release; Polymer hydration; Texture analyzer

Indexed keywords

IBUPROFEN; MACROGOL; PARACETAMOL; POLYMER; WATER; DRUG CARRIER; MACROGOL DERIVATIVE;

ARTICLE; DELAYED DRUG RELEASE; DRUG DIFFUSION; DRUG DOSAGE FORM; DRUG SOLUBILITY; HYDRATION; HYDROGEL; HYDROPHILICITY; MATHEMATICAL ANALYSIS; PROCESS OPTIMIZATION; TABLET FORMULATION; CHEMICAL MODEL; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG FORMULATION; KINETICS; METHODOLOGY; PHARMACEUTICS; REPRODUCIBILITY; SOLUBILITY; TABLET;

ACETAMINOPHEN; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGELS; IBUPROFEN; KINETICS; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; REPRODUCIBILITY OF RESULTS; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 51449120732     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9060-x     Document Type: Article

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