Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride

Journal of Controlled Release

Volumn 81, Issue 1-2, 2002, Pages 45-56

  Krishnaiah, Y S R ^a   Karthikeyan, R S ^a   Gouri Sankar, V ^a   Satyanarayana, V ^a  

^a ANDHRA UNIVERSITY   (India)

Author keywords

Controlled drug delivery; Guar gum; Highly water soluble drugs; In vitro dissolution; Three layer matrix tablets; Trimetazidine dihydrochloride

Indexed keywords

EXCIPIENT; GUAR GUM; HYDROXYPROPYLMETHYLCELLULOSE; MAGNESIUM STEARATE; STARCH; TALC; TRIMETAZIDINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; EVALUATION; HARDNESS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TABLET; TABLET FORMULATION; THICKNESS;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GALACTANS; MANNANS; PLANT GUMS; RATS; SOLUBILITY; TABLETS, ENTERIC-COATED; TRIMETAZIDINE; VASODILATOR AGENTS;

EID: 0037123719     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00031-7     Document Type: Article

References (14)

1. Efficacy of trimetazidine in stable effort angina. Double blind study against placebo
2. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery
3. Gamma scintigraphic studies on guar gum matrix tablets for colon-specific drug delivery in healthy subjects
4. Evaluation of guar gum as compression coat for drug targeting to colon
5. Studies on guar gum compression coated 5-amino salicylic acid tablets for colon-specific drug delivery
6. Guar gum based sustained release diltiazem
7. Guar gum as a hydrophilic matrix for preparation of theophylline controlled-release dosage form
8. Controlled-release tablet formulation of Isoniazid
9. A study on the in-vitro evaluation of guar gum as a carrier for oral controlled drug delivery
10. Mechanisms of solute release from porous hydrophilic polymers
11. Regulatory aspects of stability testing in Europe
12. Antianginal efficacy of the combination of trimetazidine-propranolol compared with isosorbide dinitrate-propranolol in patients with stable angina