Design and evaluation of 1- and 3-layer matrices of verapamil hydrochloride for sustaining its release

AAPS PharmSciTech

Volumn 6, Issue 4, 2005, Pages

  Siahi, Mohammad Reza ^a   Barzegar Jalali, Mohammad ^a   Monajjemzadeh, Farnaz ^a   Ghaffari, Fatemeh ^a   Azarmi, Shirzad ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1 and 3 layer matrix; Acacia; HPMC; Sustained release; Tragacanth; Verapamil

Indexed keywords

GUM ARABIC; GUM TRAGACANTH; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; VERAPAMIL;

ARTICLE; DIFFUSION; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; KINETICS; SUSTAINED RELEASE PREPARATION; TABLET; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG SCREENING; ENTERIC COATED TABLET; METHODOLOGY; PHARMACEUTICS; SYNTHESIS;

CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG EVALUATION, PRECLINICAL; TABLETS, ENTERIC-COATED; TECHNOLOGY, PHARMACEUTICAL; VERAPAMIL;

EID: 33645528791     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt060477     Document Type: Article

References (19)

1. Peppas NA. Hydrogels in Medicine and Pharmacy. Vols 1-3. Boca Raton, FL: CRC Press; 1988.
2. Conte U, Maggi L, Colombo P, La Manna A. Multilayered hydrophilic matrices as constant release devices (Geomatrix Systems). J Control Release. 1993;26:39-47.
3. Narasimhan B, Langer R. Zero-order release of micro- and macromolecules from polymeric devices: the role of burst effect. J Control Release. 1997;47:13-20.
4. Lee ES, Kim SW, Kim SH, Cardinal JR, Jacobs H. Drug release from hydrogel devices with rate-controlling barriers. J Membr Sci. 1980;7:293-303.
5. Bodmeier R, Paeratakul O. Drug release from laminated polymeric films prepared from aqueous latexes. J Pharm Sci. 1990;79:32-36.
6. Krishnaiah YS, Karthikeyan RS, Gouri Sankar V, Satyanarayana V. Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride. J Control Release. 2002;81:45-56.
7. Wade A, Weller PJ. Handbook of Pharmaceutical Excipients. London, UK: The Pharmaceutical Press; 1994.
8. Khan KA. Concept of dissolution efficiency. J Pharm Pharmacol. 1975;27:48-49.
9. Peppas NA, Sahlin JJ. A simple equation for the description of solute release. 3. Coupling of diffusion and relaxation. Int J Pharm. 1989;57:169-172.
10. Chukwu KI, Udeala OK. Binding effectiveness of Colocasia esculenta gum in poorly compressible drugs-paracetamol and metronidazole tablet formulations. Boll Chim Farm. 2000;139:89-97.
11. Bhardwaj TR, Kanwar M, Lal R, Gupta A. Natural gums and modified natural gums as sustained release carriers. Drug Dev Ind Pharm. 2000;26:1025-1038.
12. Meshali MM, Gabr KE. Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behavior of chlorpromazine HCl. Int J Pharm. 1993;89:177-181.
13. Johnston D, Gray MR, Reed CS, Bonner FW, Anderson NH. Comparative evaluation of 5 common suspending agents used in drug safety studies. Drug Dev Ind Pharm. 1990;16:1893-1909.
14. Chukwu A. Studies on Detarium microcarpium gum. 2. Investigation as a prolonged release matrix for encapsulated chlorpheniramine maleate. STP Pharma Sci. 1994;4:399-403.
15. Chukwu A. Studies on Detarium microcarpium gum. 3. In vitro characteristics of prolonged release chlorpheniramine maleate tablets. STP Pharma Sci. 1994;4:404-408.
16. Berens AR, Hopfenberg HB. Diffusion and relaxation in glassy polymer powders. 2. Separation of diffusion and relaxation parameters. Polymers. 1978;19:489-497.
17. Pham AT, Lee PI. Probing the mechanism of drug release from hydroxypropylmethyl cellulose matrices. Pharm Res. 1994;11:1379-1384.
18. Durig T, Fassihi R. Guar-based monolithic matrix systems: effect of ionizable and non-ionizable substances and excipients on gel dynamics and release kinetics. J Control Release. 2002;80:45-56.
19. Pillay V, Fassihi R. A novel approach for constant rate delivery of highly soluble bioactives from a simple monolithic system. J Control Release. 2000;67:67-78.