Modulation of drug release kinetics from hydroxypropyl methyl cellulose matrix tablets using polyvinyl pyrrolidone

International Journal of Pharmaceutics

Volumn 337, Issue 1-2, 2007, Pages 246-253

  Hardy, Ian J ^a   Windberg Baarup, Anne ^b   Neri, Claudia ^a   Byway, Paul V ^a   Booth, Steven W ^a   Fitzpatrick, Shaun ^a  

^a Merck Sharp & Dohme Limited   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Bi modal release; HPMC; Matrix tablet; NIR imaging; PVP; Zero order release

Indexed keywords

CAFFEINE; HYDROXYPROPYLMETHYLCELLULOSE; POVIDONE;

ARTICLE; COST EFFECTIVENESS ANALYSIS; DISSOLUTION; EXCIPIENT COMPATIBILITY; FLOW KINETICS; MATHEMATICAL MODEL; NEAR INFRARED SPECTROSCOPY; PREDICTION; PRIORITY JOURNAL; REGULATORY MECHANISM; RELIABILITY; SUSTAINED DRUG RELEASE; TABLET; TABLET MATRIX; VALIDATION PROCESS; VISCOSITY;

CAFFEINE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; EXCIPIENTS; KINETICS; METHYLCELLULOSE; MICROSCOPY; MODELS, CHEMICAL; POVIDONE; RHEOLOGY; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY; WATER;

EID: 34248550987     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.01.026     Document Type: Article

References (20)

1. Alderman D. A review of cellulose ethers in hydrophilic matrices. Int. J. Pharm. Tech. Prod. Manuf. 5 (1984) 1-9
2. Clarke F. Extracting process related information from pharmaceutical dosage forms using near infrared microscopy. Vib. Spectro. 34 (2004) 25-35
3. Colombo P., Bettini R., Santi P., De Ascentis A., and Peppas N.A. Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport. J. Controlled Release 39 (1996) 231-237
4. Colombo P., Bettini R., and Peppas N.A. Observation of swelling processes and diffusion front position during swelling in hydroxypropyl methyl cellulose (HPMC) matrices containing a soluble drug. J. Controlled Release 61 (1999) 83-91
5. Conte U., and Maggi L. Modulation of the dissolution profiles from Geomatrix multi-layer matrix tablets containing drugs of different solubility. Biomaterials 17 (1996) 889-896
6. Dankwerts M.P. Development of a zero order release compressed tablet with potential for commercial tabletting process. Int. J. Pharm. 112 (1994) 37-45
7. Ford J.L., Rubinstein M.H., McCaul F., Hogan J.E., and Edgar P.J. Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets. Int. J. Pharm. 40 (1987) 223-234
8. Hiremath A.C., Sherigara B.S., Prashantha K., Sheshappa Rai K., and Prassanna Kumar S. Studies on the miscibility of hydroxypropyl methyl cellulose and poly(vinyl pyrollidone) blends. Indian J. Chem. Technol. 9 (2002) 312-315
9. Harland R.S., Gazzinga A., Sangalli M.E., Colombo P., and Peppas N.A. Drug/polymer matrix swelling and dissolution. Pharm. Res. 5 (1988) 488-494
10. Lapidus H., and Lordi N.G. Drug release from compressed hydrophilic matrices. J. Pharm. Sci. 57 (1968) 1292-1301
11. Macleod G.S., Fell J.T., and Collett J.H. An in-vitro investigation into the potential for bi-modal drug release from pectin/chitosan/HPMC coated tablets. Int. J. Pharm. 188 (1999) 11-18
12. Melia C.D. Hydrophilic matrix sustained release systems based on polysaccharide carriers. Crit. Rev. Ther. Drug. 8 (1990) 395-421
13. Ranga Rao K.V., Padmalatha Devi K., and Buri P. Influence of molecular size and water solubility of the solute on its release from swelling and erosion controlled polymeric matrices. J. Controlled Release 12 (1990) 133-141
14. Rowe R.C., Sheskey P.J., and Weller P.J. Handbook of Pharmaceutical Excipients (2003), Pharmaceutical Press, London pp. 508-513
15. Shah A.C. Design of oral sustained release drug delivery systems: in-vitro/in-vivo considerations. In: Yacobi A., and Haperin-Walega E. (Eds). Oral Sustained Release Formulations Design and Evaluation (1988), Pergamon Press, New York 35-56
16. Shenouda L.S., Adams K.A., and Zoglio M.A. A controlled delivery system using two hydrophilic polymers. Int. J. Pharm. 61 (1990) 127-134
17. Streubel A., Siepmann J., Peppas N.A., and Bodmeier R. Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design. J. Controlled Release 69 (2000) 455-468
18. Vazquez M.J., Perez-Marcos J.L., Gomez-Amoza R., Martinez-Pacheco R., Souto C., and Concheiro A. Influence of technological variables on release of drugs from hydrophilic matrices. Drug Dev. Ind. Pharm. 18 (1992) 1355-1375
19. Wang Y., Lee L., Somma R., Thompson G., Bakhtiar R., Lee J., Rekhi G.S., Lau H., Sedek G., and Hossain M. In vitro dissolution and in vivo oral absorption of methylphenidate from a biomodal release formulation in healthy volunteers. Biopharm. Drug Dispos. 25 (2004) 91-98
20. Zoglio M.A., Maulding H.V., and Carstensen J.T. Linearization of drug delivery from sustained release dosage forms, synthetic gel systems. Drug Dev. Ind. Pharm. 22 (1996) 431-437