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Volumn 45, Issue 8, 2007, Pages 1319-1332

Reproductive safety studies with genistein in rats

Author keywords

Daidzein; Estrogen; Genistein; Isoflavone; Phytoestrogen; Rats; Reproductive toxicity blood levels; Reproductive tract; Safety; Soy; Teratogenicity; Toxicity

Indexed keywords

GENISTEIN;

EID: 34447094731     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.01.009     Document Type: Article
Times cited : (71)

References (61)
  • 3
    • 0038613123 scopus 로고    scopus 로고
    • Phytoestrogens and osteoporosis: what is a safe dose?
    • Barnes S. Phytoestrogens and osteoporosis: what is a safe dose?. British Journal of Nutrition 89 Suppl. 1 (2003) S101-S108
    • (2003) British Journal of Nutrition , vol.89 , Issue.SUPPL. 1
    • Barnes, S.1
  • 4
    • 0002684311 scopus 로고
    • A specific breeding problem of sheep on subterranean clover pastures in Western Australia
    • Bennetts H.W., Underwood E.J., and Shier F.L. A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Australian Veterinary Journal 22 (1946) 2-12
    • (1946) Australian Veterinary Journal , vol.22 , pp. 2-12
    • Bennetts, H.W.1    Underwood, E.J.2    Shier, F.L.3
  • 5
    • 0019806298 scopus 로고
    • Quantitation of rat embryonic development in vitro: a morphological scoring system
    • Brown N.A., and Fabro S. Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology 24 (1981) 65-78
    • (1981) Teratology , vol.24 , pp. 65-78
    • Brown, N.A.1    Fabro, S.2
  • 6
    • 0034087129 scopus 로고    scopus 로고
    • Genistein regulation of transforming growth factor-alpha, epidermal growth factor (EGF), and EGF receptor expression in the rat uterus and vagina
    • Brown N.M., and Lamartiniere C.A. Genistein regulation of transforming growth factor-alpha, epidermal growth factor (EGF), and EGF receptor expression in the rat uterus and vagina. Cellular Growth and Differentiation 11 (2000) 255-260
    • (2000) Cellular Growth and Differentiation , vol.11 , pp. 255-260
    • Brown, N.M.1    Lamartiniere, C.A.2
  • 7
    • 0032752637 scopus 로고    scopus 로고
    • Developmental effects of dietary phytoestrogens in Sprague Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro
    • Casanova M., You L., Gaido K.W., Archibeque-Engle S., Janszen D.B., and Heck H.A. Developmental effects of dietary phytoestrogens in Sprague Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro. Toxicological Sciences 51 (1999) 236-244
    • (1999) Toxicological Sciences , vol.51 , pp. 236-244
    • Casanova, M.1    You, L.2    Gaido, K.W.3    Archibeque-Engle, S.4    Janszen, D.B.5    Heck, H.A.6
  • 11
    • 0034062036 scopus 로고    scopus 로고
    • Analysis of soy isoflavones conjugation in vitro and in human blood using liquid chromatography
    • Doerge D.R., Chang H.C., Churchwell M.I., and Holder C.L. Analysis of soy isoflavones conjugation in vitro and in human blood using liquid chromatography. Drug Metabolism and Disposition 28 (2000) 298-307
    • (2000) Drug Metabolism and Disposition , vol.28 , pp. 298-307
    • Doerge, D.R.1    Chang, H.C.2    Churchwell, M.I.3    Holder, C.L.4
  • 12
    • 0035037554 scopus 로고    scopus 로고
    • Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats
    • Doerge D.R., Churchwell M.I., Chang H.C., Newbold R.R., and Delclos K.B. Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats. Reproductive Toxicology 15 (2001) 105-110
    • (2001) Reproductive Toxicology , vol.15 , pp. 105-110
    • Doerge, D.R.1    Churchwell, M.I.2    Chang, H.C.3    Newbold, R.R.4    Delclos, K.B.5
  • 13
    • 0037151246 scopus 로고    scopus 로고
    • Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure
    • Fielden M.R., Fong C.J., Haslam S.Z., and Zacharewski T.R. Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure. Toxicology Letters 133 (2002) 181-191
    • (2002) Toxicology Letters , vol.133 , pp. 181-191
    • Fielden, M.R.1    Fong, C.J.2    Haslam, S.Z.3    Zacharewski, T.R.4
  • 14
    • 0037399936 scopus 로고    scopus 로고
    • Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality and mice
    • Fielden M.R., Samy S.M., Chou K.C., and Zacharewski T.R. Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality and mice. Food and Chemical Toxicology 41 (2003) 447-454
    • (2003) Food and Chemical Toxicology , vol.41 , pp. 447-454
    • Fielden, M.R.1    Samy, S.M.2    Chou, K.C.3    Zacharewski, T.R.4
  • 16
    • 0034470319 scopus 로고    scopus 로고
    • Multigenerational exposure to dietary genistein has no severe effects on nursing behavior in rats
    • Flynn K.M., Ferguson S.A., Delclos K.B., and Newbold R.R. Multigenerational exposure to dietary genistein has no severe effects on nursing behavior in rats. Neurotoxicology 21 (2000) 997-1001
    • (2000) Neurotoxicology , vol.21 , pp. 997-1001
    • Flynn, K.M.1    Ferguson, S.A.2    Delclos, K.B.3    Newbold, R.R.4
  • 17
    • 0032437643 scopus 로고    scopus 로고
    • Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat
    • Fritz W.A., Coward L., Wang J., and Lamartiniere C.A. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. Carcinogenesis 19 (1998) 2151-2158
    • (1998) Carcinogenesis , vol.19 , pp. 2151-2158
    • Fritz, W.A.1    Coward, L.2    Wang, J.3    Lamartiniere, C.A.4
  • 19
    • 0038267307 scopus 로고    scopus 로고
    • Dietary diethylstilbestrol but not genistein adversely affects rat testicular development
    • Fritz W.A., Cotroneo M.S., Wang J., Eltoum I.E., and Lamartiniere C.A. Dietary diethylstilbestrol but not genistein adversely affects rat testicular development. Journal of Nutrition 133 (2003) 2287-2293
    • (2003) Journal of Nutrition , vol.133 , pp. 2287-2293
    • Fritz, W.A.1    Cotroneo, M.S.2    Wang, J.3    Eltoum, I.E.4    Lamartiniere, C.A.5
  • 20
    • 0345411501 scopus 로고    scopus 로고
    • Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights
    • Gallavan R.H., Holson J.F., Stump D.G., Knapp J.F., and Reynolds V.L. Interpreting the toxicologic significance of alterations in anogenital distance: potential for confounding effects of progeny body weights. Reproductive Toxicology 13 (1999) 383-390
    • (1999) Reproductive Toxicology , vol.13 , pp. 383-390
    • Gallavan, R.H.1    Holson, J.F.2    Stump, D.G.3    Knapp, J.F.4    Reynolds, V.L.5
  • 21
    • 0034522066 scopus 로고    scopus 로고
    • Promotion of health by soy isoflavones: efficacy, benefit and safety concerns
    • Goldwyn S., Lazinsky A., and Wei H. Promotion of health by soy isoflavones: efficacy, benefit and safety concerns. Drug Metabolism and Drug Interaction 17 (2000) 261-289
    • (2000) Drug Metabolism and Drug Interaction , vol.17 , pp. 261-289
    • Goldwyn, S.1    Lazinsky, A.2    Wei, H.3
  • 22
    • 0031970216 scopus 로고    scopus 로고
    • Maternal genistein exposure mimics the effect of estrogen on mammary gland development in female mouse offspring
    • Hilakivi-Clarke L., Cho E., and Clarke R. Maternal genistein exposure mimics the effect of estrogen on mammary gland development in female mouse offspring. Oncology Reports 5 (1998) 609-616
    • (1998) Oncology Reports , vol.5 , pp. 609-616
    • Hilakivi-Clarke, L.1    Cho, E.2    Clarke, R.3
  • 23
    • 0032170032 scopus 로고    scopus 로고
    • Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo
    • Hsieh C.Y., Santell R.C., Haslam S.Z., and Helferich W.G. Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Research 58 (1998) 3833-3838
    • (1998) Cancer Research , vol.58 , pp. 3833-3838
    • Hsieh, C.Y.1    Santell, R.C.2    Haslam, S.Z.3    Helferich, W.G.4
  • 24
    • 0032866285 scopus 로고    scopus 로고
    • Quantification of soy isoflavones, genistein, daidzein and conjugates in rat blood using LC/ES-MS
    • Holder C.L., Churchwell M.I., and Doerge D.R. Quantification of soy isoflavones, genistein, daidzein and conjugates in rat blood using LC/ES-MS. Journal of Agriculture and Food Chemistry 47 (1999) 3764-3770
    • (1999) Journal of Agriculture and Food Chemistry , vol.47 , pp. 3764-3770
    • Holder, C.L.1    Churchwell, M.I.2    Doerge, D.R.3
  • 25
    • 0029044121 scopus 로고
    • Urinary isoflavinoid, phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products
    • Hutchins A.M., Slavin J.L., and Lampe J.W. Urinary isoflavinoid, phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products. Journal of the American Dietary Association 95 (1995) 545-551
    • (1995) Journal of the American Dietary Association , vol.95 , pp. 545-551
    • Hutchins, A.M.1    Slavin, J.L.2    Lampe, J.W.3
  • 27
    • 0024773107 scopus 로고
    • Reproductive and general metabolic effects of phytoestrogens in mammals
    • Kaldas R.S., and Hughes C.L. Reproductive and general metabolic effects of phytoestrogens in mammals. Reproductive Toxicology 3 (1989) 81-89
    • (1989) Reproductive Toxicology , vol.3 , pp. 81-89
    • Kaldas, R.S.1    Hughes, C.L.2
  • 28
    • 0036133202 scopus 로고    scopus 로고
    • Lack of adverse effects in the F1 offspring maternally exposed to genistein at human intake dose level
    • Kang K.S., Che J.H., and Lee Y.S. Lack of adverse effects in the F1 offspring maternally exposed to genistein at human intake dose level. Food and Chemical Toxicology 40 (2002) 43-51
    • (2002) Food and Chemical Toxicology , vol.40 , pp. 43-51
    • Kang, K.S.1    Che, J.H.2    Lee, Y.S.3
  • 29
    • 0029960272 scopus 로고
    • A review of the clinical effects of phytoestrogens
    • Knight D.C., and Eden J.A. A review of the clinical effects of phytoestrogens. Obstetrics and Gynecology 87 (1994) 897-904
    • (1994) Obstetrics and Gynecology , vol.87 , pp. 897-904
    • Knight, D.C.1    Eden, J.A.2
  • 31
    • 0031769484 scopus 로고    scopus 로고
    • Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity
    • Lamartiniere C.A., Zhang J.X., and Cotroneo M.S. Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity. American Journal of Clinical Nutrition 68 (1998) 1400S-1405S
    • (1998) American Journal of Clinical Nutrition , vol.68
    • Lamartiniere, C.A.1    Zhang, J.X.2    Cotroneo, M.S.3
  • 34
    • 0142250748 scopus 로고    scopus 로고
    • Impact of dietary exposure to methoxychlor, genistein or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life
    • Masutomi N., Shibutani M., Takagi H., Uneyama C., Takahashi N., and Hirose M. Impact of dietary exposure to methoxychlor, genistein or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. Toxicology 192 (2003) 149-170
    • (2003) Toxicology , vol.192 , pp. 149-170
    • Masutomi, N.1    Shibutani, M.2    Takagi, H.3    Uneyama, C.4    Takahashi, N.5    Hirose, M.6
  • 36
    • 0036790042 scopus 로고    scopus 로고
    • Phytoestrogen concentrations in serum from Japanese men and women over forty years of age
    • Morton M.S., Arisaka O., Miyake N., Morgan L.D., and Evans B.A.J. Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. Journal of Nutrition 132 (2002) 3168-3171
    • (2002) Journal of Nutrition , vol.132 , pp. 3168-3171
    • Morton, M.S.1    Arisaka, O.2    Miyake, N.3    Morgan, L.D.4    Evans, B.A.J.5
  • 38
    • 0017928819 scopus 로고
    • Whole embryo culture and the study of mammalian embryos during organogenesis
    • New D.A. Whole embryo culture and the study of mammalian embryos during organogenesis. Biological Reviews Cambridge Philosophical Society 53 (1978) 81-122
    • (1978) Biological Reviews Cambridge Philosophical Society , vol.53 , pp. 81-122
    • New, D.A.1
  • 39
    • 34447098238 scopus 로고    scopus 로고
    • NTP, 2006. Multigenerational Reproductive Toxicology Study of Genistein (Cas No. 446-72-0) in Sprague Dawley Rats (Feed Study), Document TR 539, National Toxicology Program.
  • 40
    • 34447108964 scopus 로고    scopus 로고
    • NTP CERHR, 2006. National Toxicology Program Center for the Evaluation of Risks to Human Reproduction, expert panel evaluation of genistein and soy formula, March 15-17, 2006, CERHR website (http://cerhr.niehs.nih.gov) and available in printed text from CERHR in May 2006.
  • 42
    • 34447092462 scopus 로고    scopus 로고
    • Plassmann, S., 1997. Ro 24-2076/000 Segment II: Oral study for effects on embryo-fetal development in the rat. Hoffmann La Roche Ltd., Basle Research Report B-0164609.
  • 43
    • 0034488610 scopus 로고    scopus 로고
    • Effects of chronic dietary exposure to genistein, a phytoestrogen, during various stages of development on reproductive hormones and spermatogenesis in rats
    • Roberts D., Veeramachaneni D.N., Schlaff W.D., and Awoniyi C.A. Effects of chronic dietary exposure to genistein, a phytoestrogen, during various stages of development on reproductive hormones and spermatogenesis in rats. Endocrinology 13 (2000) 281-286
    • (2000) Endocrinology , vol.13 , pp. 281-286
    • Roberts, D.1    Veeramachaneni, D.N.2    Schlaff, W.D.3    Awoniyi, C.A.4
  • 44
    • 34447109993 scopus 로고    scopus 로고
    • Schmitt, G., 1997. The teratogenic potential of genistein: whole embryo culture assay. Hoffmann La Roche Ltd., Basle Research Report B-0167288.
  • 45
    • 0033998540 scopus 로고    scopus 로고
    • Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants
    • Setchell K.D. Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants. Journal of Nutrition 130 (2000) 654S-655S
    • (2000) Journal of Nutrition , vol.130
    • Setchell, K.D.1
  • 49
    • 0034863342 scopus 로고    scopus 로고
    • Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis
    • Sirtori C.R. Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis. Drug Safety 24 (2001) 665-682
    • (2001) Drug Safety , vol.24 , pp. 665-682
    • Sirtori, C.R.1
  • 50
    • 34447107469 scopus 로고    scopus 로고
    • Sterz, H., 1977. Routine examination of rat and rabbit fetuses for malformation of internal organs combination of Barrow's and Wilson's methods. In: Neubert, D., Merker, H.J., Kwasigroch, T.E. (Eds.), Methods in Prenatal Toxicology. Stuttgart Georg Thieme, 113-125.
  • 52
    • 0034982227 scopus 로고    scopus 로고
    • Pharmacological activities of genistein, an isoflavone from soy (Glysine max): part I-anti-cancer activity
    • Suthar A.C., Banavalikar M.M., and Biyani M.K. Pharmacological activities of genistein, an isoflavone from soy (Glysine max): part I-anti-cancer activity. Indian Journal of Experimental Biology 39 (2001) 511-519
    • (2001) Indian Journal of Experimental Biology , vol.39 , pp. 511-519
    • Suthar, A.C.1    Banavalikar, M.M.2    Biyani, M.K.3
  • 53
    • 0034981976 scopus 로고    scopus 로고
    • Pharmacological activities of genistein, an isoflavone from soy (Glysine max): part II-anti-cholesterol activity, effects on osteoporosis and menopausal symptoms
    • Suthar A.C., Banavalikar M.M., and Biyani M.K. Pharmacological activities of genistein, an isoflavone from soy (Glysine max): part II-anti-cholesterol activity, effects on osteoporosis and menopausal symptoms. Indian Journal of Experimental Biology 39 (2001) 520-525
    • (2001) Indian Journal of Experimental Biology , vol.39 , pp. 520-525
    • Suthar, A.C.1    Banavalikar, M.M.2    Biyani, M.K.3
  • 54
    • 0029947174 scopus 로고    scopus 로고
    • Molecular effects of genistein on estrogen receptor mediated pathways
    • Wang T.T., Sathyamoorthy N., and Phang J.M. Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis 17 (1996) 271-275
    • (1996) Carcinogenesis , vol.17 , pp. 271-275
    • Wang, T.T.1    Sathyamoorthy, N.2    Phang, J.M.3
  • 55
    • 0002990833 scopus 로고
    • Wilson J.G., and Warkany J. (Eds), The University of Chicago Press, Chicago and London
    • Wilson J.G. In: Wilson J.G., and Warkany J. (Eds). Teratology, Principles and Techniques (1965), The University of Chicago Press, Chicago and London 265-277
    • (1965) Teratology, Principles and Techniques , pp. 265-277
    • Wilson, J.G.1
  • 56
    • 0037376958 scopus 로고    scopus 로고
    • Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats
    • Wisniewski A.B., Klein S.L., Lakshmaman Y., and Gearhart J.P. Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats. Journal of Urology 169 (2003) 1582-1586
    • (2003) Journal of Urology , vol.169 , pp. 1582-1586
    • Wisniewski, A.B.1    Klein, S.L.2    Lakshmaman, Y.3    Gearhart, J.P.4
  • 57
    • 13544271676 scopus 로고    scopus 로고
    • Perinatal exposure to genistein alters reproductive development and aggressive behavior in male mice
    • Wisniewski A.B., Cernetich A., Gearhart J.P., and Klein S.L. Perinatal exposure to genistein alters reproductive development and aggressive behavior in male mice. Physiology and Behavior 84 (2005) 327-334
    • (2005) Physiology and Behavior , vol.84 , pp. 327-334
    • Wisniewski, A.B.1    Cernetich, A.2    Gearhart, J.P.3    Klein, S.L.4
  • 58
    • 34447095681 scopus 로고    scopus 로고
    • Wolz, E., Pfannkuch, F., Schmitt, G., Howald, M., Knuppe, C., Becker, H., 2001. Ro 24-2076/000 (Genistein): Prenatal developmental toxicity study in the rat. Hoffmann La Roche Ltd., Basle Regulatory Document RDR-1005025.
  • 59
    • 0034795213 scopus 로고    scopus 로고
    • Validity and reproducibility of a self-administered food frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records in blood and urine isoflavones
    • Yamamoto S., Sobue T., Sasaki S., Kobayashi B., Arai Y., Uehara M., Adlercreutz H., Watanabe S., Takahashi T., Litoi Y., Iwase Y., Akabane M., and Tsugane S. Validity and reproducibility of a self-administered food frequency questionnaire to assess isoflavone intake in a Japanese population in comparison with dietary records in blood and urine isoflavones. Journal of Nutrition 131 (2001) 2741-2747
    • (2001) Journal of Nutrition , vol.131 , pp. 2741-2747
    • Yamamoto, S.1    Sobue, T.2    Sasaki, S.3    Kobayashi, B.4    Arai, Y.5    Uehara, M.6    Adlercreutz, H.7    Watanabe, S.8    Takahashi, T.9    Litoi, Y.10    Iwase, Y.11    Akabane, M.12    Tsugane, S.13
  • 60
    • 0036194969 scopus 로고    scopus 로고
    • Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague Dawley rats: genistein and methoxychlor
    • You L., Casanova M., Bartolucci E.J., Fryczynski M.W., Dorman D.C., Everitt J.I., Gaido K.W., Ross S.M., and Heck H.A. Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague Dawley rats: genistein and methoxychlor. Toxicological Sciences 66 (2002) 91-104
    • (2002) Toxicological Sciences , vol.66 , pp. 91-104
    • You, L.1    Casanova, M.2    Bartolucci, E.J.3    Fryczynski, M.W.4    Dorman, D.C.5    Everitt, J.I.6    Gaido, K.W.7    Ross, S.M.8    Heck, H.A.9
  • 61
    • 0007139589 scopus 로고    scopus 로고
    • Chemical effects on processing and food preparation on carotenoids and soy and garlic phytochemicals
    • Lachance P.A. (Ed), Food and Nutrition Press, Trumbull, C.T
    • Zhou J.R., and Erdman J.W. Chemical effects on processing and food preparation on carotenoids and soy and garlic phytochemicals. In: Lachance P.A. (Ed). Nutraceuticals: Designer Foods III. Garlic soy and licorice (1997), Food and Nutrition Press, Trumbull, C.T 23-37
    • (1997) Nutraceuticals: Designer Foods III. Garlic soy and licorice , pp. 23-37
    • Zhou, J.R.1    Erdman, J.W.2


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