Comparison of developmental toxicology of aspirin (acetylsalicylic acid) in rats using selected dosing paradigms

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 68, Issue 1, 2003, Pages 27-37

  Gupta, Utpal ^a   Cook, Jon C ^a   Tassinari, Melissa S ^a   Hurtt, Mark E ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Aspirin; Developmental toxicity; Rat; Teratology

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DIAPHRAGM HERNIA; DOSE RESPONSE; DRUG MEGADOSE; FEMALE; FETUS; FETUS MALFORMATION; GASTROINTESTINAL TOXICITY; GESTATIONAL AGE; HEART VENTRICLE SEPTUM DEFECT; HYDROCEPHALUS; INCIDENCE; MAXIMUM TOLERATED DOSE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RABBIT; RAT; REPRODUCTIVE TOXICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EATING; FEMALE; GESTATIONAL AGE; HEART SEPTAL DEFECTS, VENTRICULAR; HERNIA, DIAPHRAGMATIC; MATERNAL EXPOSURE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPECIES SPECIFICITY; TERATOGENS;

ANIMALIA; ORYCTOLAGUS CUNICULUS; RATTUS NORVEGICUS;

EID: 0141892545     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.10007     Document Type: Article

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