Monomethylarsonic acid and dimethylarsinic acid: Developmental toxicity studies with risk assessment

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 77, Issue 1, 2006, Pages 53-68

  Irvine, Lorraine ^a   Boyer, Ivan J ^b   DeSesso, John M ^b  

^a toXcel International Ltd   (United Kingdom)

^b NOBLIS   (United States)

Author keywords

DMA; MMA; Organoarsenicals; Rabbits; Rats; Safety assessment

Indexed keywords

CACODYLIC ACID; METHANEARSONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DIAPHRAGM HERNIA; FEMALE; FETOTOXICITY; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RABBIT; RAT; REVIEW; RISK ASSESSMENT;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ARSENICALS; CACODYLIC ACID; FEMALE; FETUS; LITTER SIZE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT;

ANIMALIA; MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33645934505     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20065     Document Type: Review

References (57)

1. Abernathy CO, Thomas DJ, Calderon R. 2003. Health effects and risk assessment of arsenic. J Nutr 133(Suppl):1536S-1538S.
2. Aposhian HV. 1989. Biochemical toxicology of arsenic. Rev Biochem Toxicol 10:265-299.
3. Aposhian HV. 1997. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu Rev Pharmacol Toxicol 37:397-419.
4. Aposhian V, Zakharyan RA, Avram MD, Sampayo-Reyes R, Wollenberg ML. 2004. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicol Appl Pharmacol 198:327-335.
5. Armitage P. 1955. Tests for linear trends in proportions and frequencies. Biometrics 11:375-386.
6. Beck BD. 2004. Lack of relevance of DMA rat bladder carcinogenicity for human risk assessment of methylated arsenic compounds. Cambridge, MA: Gradient Corporation. 76p.
7. Biodynamics. 1990. A teratology study in rats with methanearsonic acid. Unpublished report. Ref. 89-0130, Sept., 1990. New Jersey: Biodynamics Inc.
8. Bradley JV. 1968. Distribution free statistical tests. Englewood Cliffs, NJ: Prentice-Hall, p 195-203.
9. Charles River. 1988. Embryo and fetal development toxicity (teratology) control data in the Charles River Crl:CD® BR rat. Charles River Laboratories, Wilmington, MA, 01 Feb, 1988.
10. Chernoff N, Setzer RW, Miller DB, Rosen MB, Rogers JM. 1990. Effects of chemically induced maternal toxicity on prenatal development in the rat. Teratology 42:651-658.
11. Cohen SM, Arnold LL, Eldan M, Schoen AS, Beck BD. 2006. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit Rev Toxicol 36: in press; doi://10.1080/10408440500534230.
12. Collins TF, Welsh JJ, Black TN, Whitby KE, O'Donnell MW. 1987. Potential reversibility of skeletal effects in rats exposed in utero to caffeine. Food Chem Toxicol 25:647-662.
13. DeSesso JM. 2001. Teratogen update: inorganic arsenic. Teratology 64:170-173.
14. DeSesso JM, Jacobson CF, Scialli AR, Farr CH, Holson JF. 1998. An assessment of the developmental toxicity of inorganic arsenic. Reprod Toxicol 12:385-433.
15. Dopp E, Hartmann LM, Florea AM, von Recklinghausen U, Pieper R, Shokouhi B, Rettenmeier AW, Hirner AV, Obe G. 2004. Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells. Toxicol Appl Pharmacol 201:156-165.
16. Dunn JO. 1964. Multiple comparisons using rank sums. Technometrics 6:241-252.
17. Dunnett CW. 1955. A multiple comparison procedure for comparing several treatments with control. J Am Stat Assoc 50:1096-1121.
18. Dunnett CW. 1964. New tables for multiple comparisons with a control. Biometrics 20:482-491.
19. Environmental Protection Agency. 1982. Guideline 83-3: teratogenicity study. Pesticide assessment guidelines, Subdivision F. Hazard evaluation: human and domestic animals. EPA-540/9-82-025. Washington, DC: Office of Pesticides and Toxic Substances.
20. Fisher RA. 1934. Statistical methods for research workers. 5th ed. Edinburgh: Oliver and Boyd.
21. Freeman MF, Tukey JW. 1950. Transformations related to the angular and square root. Ann Math Stat 21:607-611.
22. Gebel TW. 2002. Arsenic methylation is a process of detoxification through accelerated excretion. Int J Hyg Environ Health 205:505-508.
23. Golub MS, Macintosh MS, Baumrind N. 1998. Developmental and reproductive toxicity of inorganic arsenic: animal studies and human concerns. J Toxicol Environ Health 1:199-241.
24. Hirano S, Kobayashi Y, Cui X, Kanno S, Hayakawa T, Shraim A. 2004. The accumulation and toxicity of methylated arsenicals in endothelial cells: important roles of thiol compounds. Toxicol Appl Pharmacol 198:458-467.
25. Hollander M, Wolfe DA. 1973. Non parametric statistical methods. New York: John Wiley and Sons.
26. Holson JF, DeSesso JM, Jacobson CF, Farr CH. 2000. Appropriate use of animal models in the assessment of risk during prenatal development. An illustration using inorganic arsenic. Teratology 62:51-71.
27. Hood RD. 1998a. Developmental effects of methylated arsenic metabolites in mice. Bull Environ Contam Toxicol 61:231-238.
28. Hood RD. 1998b. Embryonic, placental, and maternal uptake and retention of dimethylarsinic acid by species relatively sensitive (rat) or resistant (mouse) to its developmental toxicity. Res Commun Pharmacol Toxicol 3:99-104.
29. Hood RD, Harrison WP, Vedel GC. 1982. Evaluation of arsenic metabolites for prenatal effects in the hamster. Bull Environ Contam Toxicol 29:679-687.
30. Hughes MF, Kenyon EM. 1998. Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration. J Toxicol Environ Health 23:95-112.
31. Jacobson CF, Stump DG, Nemec MD, Holson JF, DeSesso JM. 1999. Appropriate exposure routes and doses in studies designed to assess developmental toxicity: a case study of inorganic arsenic. Int J Toxicol 18:361-368.
32. Judd F. 1979. Acute toxicity and effects of sublethal dietary exposure of monosodium methanearsonate herbicide to peromyscus leucopus (Rodentia; Cricetidae). Bull Environ Contam Toxicol 22:43-150.
33. Kavlock RJ, Chernoff N, Rogers EH. 1985. The effect of acute maternal toxicity on fetal development in the mouse. Teratog Carcinog Mutagen 5:3-13.
34. Life Science Research Israel. 1986. Methanearsonic acid. Teratology study in the rabbit. Unpublished Report. Ref. PAL/006/MSM, LSR Israel Inc., Ness Ziona, Israel. Mar, 1986.
35. Life Science Research Israel. 1988a. Cacodylic acid. Teratology study in the rat. Unpublished Report. Ref. PAL/017/CAC, LSR Israel Inc., Ness Ziona, Israel. Jan, 1988.
36. Life Science Research Israel. 1988b. Cacodylic acid. Teratology study in the rabbit. Unpublished Report. Ref. PAL/019/CAC, LSR Israel Inc., Ness Ziona, Israel. May, 1988.
37. Lopez JF, Judd FW. 1979. Effects of sublethal dietary exposure of monosodium methanearsonate herbicide on nest-building behaviour of the white-footed mouse, Peromyscus leucopus. Bull Environ Contam Toxicol 23:32-33.
38. Mann HB, Whitney DR. 1947. On a test of whether one of two random variables is stochastically larger than the other. Ann Math Stat 18:50-60.
39. Miller RG Jr. 1966. Simultaneous statistical interference. New York: McGraw-Hill Book Company. 15p.
40. Milton AH, Smith W, Rahman B, Hasan Z, Kulsum U, Dear K, Rakibuddin M, Ali A. 2005. Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh. Epidemiology. 16:82-86.
41. National Research Council. 2001. Arsenic in drinking water: 2001 update. Subcommittee to Update the 1999 Arsenic in Drinking Water Report, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council.
42. Okerman L. 1988. Diseases of domestic rabbits. London: Blackwell Scientific Publications. 35p.
43. Peplow D, Edmonds R. 2004. Health risks associated with contamination of groundwater by abandoned mines near Twisp in Okanogan County. Environ Geochem Health 26:69-79.
44. Prukop JA, Savage N. 1986. Some effects of multiple, sublethal doses of monosodium methanearsonate [MSMA] herbicide on hematology, growth and reproduction of laboratory mice. Bull Environ Contam Toxicol 36:337-341.
45. Rogers EH, Chernoff N, Kavlock RJ. 1981. The teratogenic potential of cacodylic acid in the rat and mouse. Drug Chem Toxicol 4:49-61.
46. Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198:394-404.
47. Rubin Y, Gal N, Nyska A, Pirak M, Waner T. 1989. Cacodylic acid two generation reproduction study in the rat, Life Science Research Israel. Unpublished report. Project No. PAL/015/CAC.
48. Snedecor GW, Cochran WG. 1967. Statistical methods. Methods for Bartlett's test, ANOVA, analysis covariance, regression-tests for trend and fit. 6th Ed. Ames, IA: Iowa State University Press.
49. Student WS. 1908. The probable error of a mean. Biometrika 6:1-25.
50. Vahter M. 2002. Mechanisms of arsenic biotransformation. Toxicology 27:181-182; 211-217.
51. Valenzuela OL, Borja-Aburto VH, Garcia-Vargas GG, Cruz-Gonzalez MB, Garcia-Montalvo EA, Calderon-Aranda ES, Del Razo LM. 2005. Urinary trivalent methylated arsenic species in a population chronically exposed to inorganic arsenic. Environ Health Perspect 113:250-254.
52. Waalkens-Berendsen DH, Koeter HB, Van Marwijk MW. 1990. Embryotoxicity of isomalt in rats and rabbits. Food Chem Toxicol 28:1-9.
53. Wickramaratne GW. 1988. The post-natal fate of supernumerary ribs in rat teratogenicity studies. J Appl Toxicol 8:91-94.
54. Willhite CC. 1981. Arsenic-induced axial skeletal (dysraphic) disorders. Exp Mol Pathol 34:145-158.
55. Yang C-Y, Chui H-F, Chang C-C, Ho S-C, Wu T-N. 2005. Bladder cancer mortality reduction after installation of a tap-water supply system in an arsenious-endemic area in southwestern Taiwan. Environ Res 98:127-132.
56. Yoshida K, Chen H, Inoue Y, Wanibuchi H, Fukushima S, Kuroda K, Endo G. 1997. The urinary excretion of arsenic metabolites after a single oral administration of dimethyl arsenic acid rats. Arch Environ Contam Toxicol 32:416-421.
57. Yoshida K, Inoue Y, Kuroda K, Chen H, Wanibuchi H, Fukushima S, Endo G. 1998. Urinary excretion of arsenic metabolites after long-term oral administration of various arsenic compounds to rats. J Toxicol Environ Health 54:179-192.