Orexin microinjection in the medullary raphe increases heart rate and arterial pressure but does not reduce tail skin blood flow in the awake rat

Neuroscience

Volumn 202, Issue , 2012, Pages 209-217

  Luong, L N L ^a   Carrive, P ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Arousal; Brown adipose tissue; Cardiovascular; Infrared thermography; Psychological stress; Thermoregulation

Indexed keywords

OREXIN A;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; AROUSAL; ARTICLE; BACK; BODY TEMPERATURE MONITORING; BRAIN REGION; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; HEART RATE; INFRARED PHOTOGRAPHY; INTERSCAPULAR BACK; LOCOMOTION; LUMBOSACRAL BACK; MALE; MEAN ARTERIAL PRESSURE; MICROINJECTION; NONHUMAN; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; RAT; ROSTRAL MEDULLARY RAPHE; SKIN BLOOD FLOW; TELEMETRY; THERMOGENESIS AND THERMOREGULATION; VASOCONSTRICTION;

ADIPOSE TISSUE, BROWN; ANIMALS; AROUSAL; BLOOD PRESSURE; BODY TEMPERATURE; DATA INTERPRETATION, STATISTICAL; HEART RATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICROINJECTIONS; MOTOR ACTIVITY; NEUROPEPTIDES; RAPHE NUCLEI; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; SKIN; SKIN TEMPERATURE; STRESS, PSYCHOLOGICAL; TAIL; TELEMETRY; THERMOGRAPHY; VASOCONSTRICTION;

EID: 84856224109     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.11.073     Document Type: Article

References (43)

1. Antunes V.R., Brailoiu G.C., Kwok E.H., Scruggs P., Dun N.J. Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol 2001, 281:R1801-R1807.
2. Berthoud H.R., Patterson L.M., Sutton G.M., Morrison C., Zheng H. Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and gastrointestinal regulation. Histochem Cell Biol 2005, 123:147-156.
3. Blessing W.W. Lower brainstem pathways regulating sympathetically mediated changes in cutaneous blood flow. Cell Mol Neurobiol 2003, 23:527-538.
4. Blessing W.W., Nalivaiko E. Raphe magnus/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats. Neuroscience 2001, 105:923-929.
5. Blumberg M.S., Efimova I.V., Alberts J.R. Thermogenesis during ultrasonic vocalization by rat pups isolated in a warm environment: a thermographic analysis. Dev Psychobiol 1992, 25:497-510.
6. Cao W.H., Morrison S.F. Glutamate receptors in the raphe pallidus mediate brown adipose tissue thermogenesis evoked by activation of dorsomedial hypothalamic neurons. Neuropharmacology 2006, 51:426-437.
7. Cao W.H., Morrison S.F. Disinhibition of rostral raphe pallidus neurons increases cardiac sympathetic nerve activity and heart rate. Brain Res 2003, 980:1-10.
8. Carrive P. Conditioned fear to environmental context: cardiovascular and behavioral components in the rat. Brain Res 2000, 858:440-445.
9. Chen C.T., Hwang L.L., Chang J.K., Dun N.J. Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am J Physiol Regul Integr Comp Physiol 2000, 278:R692-R697.
10. Ciriello J., Li Z., de Oliveira C.V. Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla. Brain Res 2003, 991:84-95.
11. de Lecea L. A decade of hypocretins: past, present and future of the neurobiology of arousal. Acta Physiol (Oxf) 2010, 198:203-208.
12. Duxon M.S., Stretton J., Starr K., Jones D.N., Holland V., Riley G., Jerman J., Brough S., Smart D., Johns A., Chan W., Porter R.A., Upton N. Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology (Berl) 2001, 153:203-209.
13. Furlong T.M., Vianna D.M., Liu L., Carrive P. Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal. Eur J Neurosci 2009, 30:1603-1614.
14. Hirota K., Kushikata T., Kudo M., Kudo T., Smart D., Matsuki A. Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats. Brain Res 2003, 981:143-150.
15. Huang S.C., Dai Y.-W.E., Lee Y.H., Chiou L.C., Hwang L.L. Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors. J Pharmacol Exp Ther 2010, 334:522-529.
16. Jansen A.S., Nguyen X.V., Karpitskiy V., Mettenleiter T.C., Loewy A.D. Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science 1995, 270:644-646.
17. Kerman I.A. Organization of brain somatomotor-sympathetic circuits. Exp Brain Res 2008, 187:1-16.
18. Luong L.N.L., Vianna D.M.L., Carrive P. A comparison of the cardiovascular and locomotor effects of orexin-A after intracerebroventricular and intrathecal administration in the conscious rat 2009, ISAN 2009 Sydney, Australia, p 7.11.
19. Machado B.H., Bonagamba L.G., Dun S.L., Kwok E.H., Dun N.J. Pressor response to microinjection of orexin/hypocretin into rostral ventrolateral medulla of awake rats. Regul Pept 2002, 104:75-81.
20. Marks A., Vianna D.M., Carrive P. Nonshivering thermogenesis without interscapular brown adipose tissue involvement during conditioned fear in the rat. Am J Physiol Regul Integr Comp Physiol 2009, 296:R1239-R1247.
21. Matsuzaki I., Sakurai T., Kunii K., Nakamura T., Yanagisawa M., Goto K. Involvement of the serotonergic system in orexin-induced behavioral alterations in rats. Regul Pept 2002, 104:119-123.
22. Mileykovskiy B.Y., Kiyashchenko L.I., Siegel J.M. Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medulla. J Neurophysiol 2002, 87:2480-2489.
23. Morgan M.M., Whittier K.L., Hegarty D.M., Aicher S.A. Periaqueductal gray neurons project to spinally projecting GABAergic neurons in the rostral ventromedial medulla. Pain 2008, 140:376-386.
24. Morrison S.F. Central pathways controlling brown adipose tissue thermogenesis. News Physiol Sci 2004, 19:67-74.
25. Nakamura K., Matsumura K., Kobayashi S., Kaneko T. Sympathetic premotor neurons mediating thermoregulatory functions. Neurosci Res 2005, 51:1-8.
26. Nakamura K., Morrison S.F. Central efferent pathways for cold-defensive and febrile shivering. J Physiol 2011, 589:3641-3658.
27. Nason M.W., Mason P. Modulation of sympathetic and somatomotor function by the ventromedial medulla. J Neurophysiol 2004, 92:510-522.
28. Ootsuka Y., McAllen R.M. Interactive drives from two brain stem premotor nuclei are essential to support rat tail sympathetic activity. Am J Physiol Regul Integr Comp Physiol 2005, 289:R1107-R1115.
29. Paxinos G., Watson C. The Rat brain in stereotaxic coordinates 2005, Academic Press, San Diego.
30. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998, 18:9996-10015.
31. Puskás N., Papp R.S., Gallatz K., Palkovits M. Interactions between orexin-immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and mice. Peptides 2010, 31:1589-1597.
32. Rathner J.A., McAllen R.M. Differential control of sympathetic drive to the rat tail artery and kidney by medullary premotor cell groups. Brain Res 1999, 834:196-199.
33. Sakurai T., Mieda M., Tsujino N. The orexin system: roles in sleep/wake regulation. Ann N Y Acad Sci 2010, 1200:149-161.
34. Samson W.K., Bagley S.L., Ferguson A.V., White M.M. Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress. Am J Physiol Regul Integr Comp Physiol 2007, 292:R382-R387.
35. Samson W.K., Bagley S.L., Ferguson A.V., White M.M. Orexin receptor subtype activation and locomotor behaviour in the rat. Acta Physiol (Oxf) 2010, 198:313-324.
36. Shahid I.Z., Rahman A.A., Pilowsky P.M. Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex. Br J Pharmacol 2011, 162:961-973.
37. Shirasaka T., Nakazato M., Matsukura S., Takasaki M., Kannan H. Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 1999, 277:R1780-R1785.
38. Tupone D., Madden C.J., Cano G., Morrison S.F. An Orexingeric projection from perifornical hypothalamus to raphe pallidus increases rat brown Adipose tissue thermogenesis. J Neurosci 2011, 31:15944-15955.
39. Vianna D.M., Allen C., Carrive P. Cardiovascular and behavioral responses to conditioned fear after medullary raphe neuronal blockade. Neuroscience 2008, 153:1344-1353.
40. Vianna D.M., Carrive P. Changes in cutaneous and body temperature during and after conditioned fear to context in the rat. Eur J Neurosci 2005, 21:2505-2512.
41. Zaretsky D.V., Zaretskaia M.V., Dimicco J.A. Stimulation and blockade of GABA(A) receptors in the raphe pallidus: effects on body temperature, heart rate, and blood pressure in conscious rats. Am J Physiol Regul Integr Comp Physiol 2003, 285:R110-R116.
42. Zaretsky D.V., Zaretskaia M.V., Samuels B.C., Cluxton L.K., Dimicco J.A. Microinjection of muscimol into raphe pallidus suppresses tachycardia associated with air stress in conscious rats. J Physiol Lond 2003, 546:243-250.
43. Zheng H., Patterson L.M., Berthoud H.R. Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function. J Comp Neurol 2005, 485:127-142.