Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex

British Journal of Pharmacology

Volumn 162, Issue 4, 2011, Pages 961-973

  Shahid, I Z ^a,b   Rahman, A A ^a,b   Pilowsky, P M ^a  

^a MACQUARIE UNIVERSITY   (Australia)

^b KHULNA UNIVERSITY   (Bangladesh)

Author keywords

baroreflex; hypoxia; Orexin A; phrenic nerve discharge; somato sympathetic reflex; sympathetic nerve activity

Indexed keywords

OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; PHENYLEPHRINE;

ADRENERGIC ACTIVITY; ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; AUTONOMIC NERVOUS SYSTEM FUNCTION; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; EXPIRATORY FLOW RATE; HEART RATE; HYPOXIA; INHALATION; MALE; MEAN ARTERIAL PRESSURE; NERVE POTENTIAL; NONHUMAN; PHRENIC NERVE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RESPIRATORY DRIVE; RESPIRATORY TRACT PARAMETERS; SCIATIC NERVE; SENSITIVITY ANALYSIS; SPLANCHNIC NERVE; SPRAGUE DAWLEY RAT; SYMPATHETIC BLOCKING; SYMPATHETIC REFLEX; TACHYCARDIA;

ANESTHESIA, SPINAL; ANIMALS; BAROREFLEX; BENZOXAZOLES; EVOKED POTENTIALS, SOMATOSENSORY; INJECTIONS, SPINAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MALE; NEURONS; NEUROPEPTIDES; PERIPHERAL NERVOUS SYSTEM; PHRENIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RESPIRATION; SPLANCHNIC NERVES; SYMPATHETIC NERVOUS SYSTEM; TACHYCARDIA; UREA; VAGOTOMY;

EID: 79251497363     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01102.x     Document Type: Article

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