Disinhibition of rostral raphe pallidus neurons increases cardiac sympathetic nerve activity and heart rate

Brain Research

Volumn 980, Issue 1, 2003, Pages 1-10

  Cao, Wei Hua ^a   Morrison, Shaun F ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Bicuculline; Blood pressure; Heart rate; Rostral ventrolateral medulla; Stress; Tachycardia

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR; BICUCULLINE; CHLORALOSE; URETHAN;

ADRENAL GLAND; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; BETA ADRENERGIC RECEPTOR BLOCKING; BRAIN REGION; CARDIOVASCULAR EFFECT; CELL POPULATION; CONTROLLED STUDY; EVOKED RESPONSE; GLOBUS PALLIDUS; HEART RATE; MICROINJECTION; NERVE CELL; NERVE CELL INHIBITION; NERVE CONDUCTION; NONHUMAN; PREGANGLIONIC NERVE; PRIORITY JOURNAL; RAT; ROSTRAL VENTROLATERAL MEDULLA; STRESS; SYMPATHETIC NERVE; SYMPATHETIC TONE; TACHYCARDIA;

EID: 0038303868     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02981-0     Document Type: Article

References (35)

1. Amendt K., Czachurski J., Dembowsky K., Seller H. Bulbospinal projections to the intermediolateral cell column: a neuroanatomical study. J. Auton. Nerv. Syst. 1:1979;103-107.
2. Andrezik J.A., Chan-Palay V., Palay S.L. The nucleus paragigantocellularis lateralis in the rat. Demonstration of afferents by the retrograde transport of horseradish peroxidase. Anat. Embryol. (Berl.). 161:1981;373-390.
3. Barman S.M., Gebber G.L. Lateral tegmental field neurons of cat medulla: a source of basal activity of raphespinal sympathoinhibitory neurons. J. Neurophysiol. 61:1989;1011-1024.
4. Brown D.L., Guyenet P.G. Cardiovascular neurons of brain stem with projections to spinal cord. Am. J. Physiol. 247:1984;R1009-1016.
5. Campos R.R., McAllen R.M. Cardiac inotropic, chronotropic, and dromotropic actions of subretrofacial neurons of cat RVLM. Am. J. Physiol. 276:1999;R1102-1111.
6. A receptor antagonist into rostral raphe pallidus (RPa) of the anesthetized rats. Soc. Neurosci. 26:2000;1186.
7. Coleman M.J., Dampney R.A. Sympathoinhibition evoked from caudal midline medulla is mediated by GABA receptors in rostral VLM. Am. J. Physiol. 274:1998;R318-323.
8. Dampney R.A. Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev. 74:1994;323-364.
9. DiMicco J.A., Stotz-Potter E.H., Monroe A.J., Morin S.M. Role of the dorsomedial hypothalamus in the cardiovascular response to stress. Clin. Exp. Pharmacol. Physiol. 23:1996;171-176.
10. Farkas E., Jansen A.S., Loewy A.D. Periaqueductal gray matter input to cardiac-related sympathetic premotor neurons. Brain Res. 792:1998;179-192.
11. Fontes M.A., Tagawa T., Polson J.W., Cavanagh S.J., Dampney R.A. Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus. Am. J. Physiol. Heart Circ. Physiol. 280:2001;H2891-2901.
12. Henderson L.A., Keay K.A., Bandler R. Delta- and kappa-opioid receptors in the caudal midline medulla mediate haemorrhage-evoked hypotension. Neuroreport. 13:2002;729-733.
13. Heslop D.J., Keay K.A., Bandler R. Haemorrhage-evoked compensation and decompensation are mediated by distinct caudal midline medullary regions in the urethane-anaesthetised rat. Neuroscience. 113:2002;555-567.
14. Hosoya Y., Sugiura Y., Zhang F.Z., Ito R., Kohno K. Direct projection from the dorsal hypothalamic area to the nucleus raphe pallidus: a study using anterograde transport with Phaseolus vulgaris leucoagglutinin in the rat. Exp. Brain Res. 75:1989;40-46.
15. Jansen A.S., Wessendorf M.W., Loewy A.D. Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion. Brain Res. 683:1995;1-24.
16. Johnson S.W., Seutin V. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci. Lett. 231:1997;13-16.
17. Khawaled R., Bruening-Wright A., Adelman J.P., Maylie J. Bicuculline block of small-conductance calcium-activated potassium channels. Pflugers Arch. 438:1999;314-321.
18. Lewis C.D., Gebber G.L., Zhong S., Larsen P.D., Barman S.M. Modes of baroreceptor-sympathetic coordination. J. Neurophysiol. 84:2000;1157-1167.
19. Loewy A.D. Raphe pallidus and raphe obscurus projections to the intermediolateral cell column in the rat. Brain Res. 222:1981;129-133.
20. Massari V.J., Johnson T.A., Gatti P.J. Cardiotopic organization of the nucleus ambiguus? An anatomical and physiological analysis of neurons regulating atrioventricular conduction. Brain Res. 679:1995;227-240.
21. McCall R.B. GABA-mediated inhibition of sympathoexcitatory neurons by midline medullary stimulation. Am. J. Physiol. 255:1988;R605-615.
22. Morrison S.F. Raphe pallidus excites a unique class of sympathetic preganglionic neurons. Am. J. Physiol. 265:1993;R82-89.
23. Morrison S.F., Gebber G.L. Raphe neurons with sympathetic-related activity: baroreceptor responses and spinal connections. Am. J. Physiol. 246:1984;R338-348.
24. Morrison S.F., Gebber G.L. Axonal branching patterns and funicular trajectories of raphespinal sympathoinhibitory neurons. J. Neurophysiol. 53:1985;759-772.
25. Morrison S.F., Ramamurthy S., Young J.B. Reduced rearing temperature augments responses in sympathetic outflow to brown adipose tissue. J. Neurosci. 20:2000;9264-9271.
26. Morrison S.F., Sved A.F., Passerin A.M. GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am. J. Physiol. 276:1999;R290-297.
27. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 2 Edition:1986;Academic Press, Sydney.
28. Ross C.A., Ruggiero D.A., Park D.H., Joh T.H., Sved A.F., Fernandez-Pardal J., Savaedra J.M., Reis D.J. Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure heart rate and plasma catecholamines and vasopressin. J. Neurosci. 4:1984;474-494.
29. Samuels B.C., Zaretsky D.V., DiMicco J.A. Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe. J. Physiol. 538:2002;941-946.
30. Soltis R.P., DiMicco J.A. Interaction of hypothalamic GABAA and excitatory amino acid receptors controlling heart rate in rats. Am. J. Physiol. 261:1991;R427-433.
31. Van Bockstaele E.J., Pieribone V.A., Aston-Jones G. Diverse afferents converge on the nucleus paragigantocellularis in the rat ventrolateral medulla: retrograde and anterograde tracing studies. J. Comp. Neurol. 290:1989;561-584.
32. Wang W.H., Lovick T.A. The inhibitory effect of the ventrolateral periaqueductal grey matter on neurones in the rostral ventrolateral medulla involves a relay in the medullary raphe nuclei. Exp. Brain Res. 94:1993;295-300.
33. Wessendorf M.W., Anderson E.G. Single unit studies of identified bulbospinal serotonergic units. Brain Res. 279:1983;93-103.
34. Zaretskaia M.V., Zaretsky D.V., Shekhar A., DiMicco J.A. Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized rats. Brain Res. 928:2002;113-125.
35. Zaretsky D.V., Zaretskaia M.V., Samuels B.C., Cluxton L.K., DiMicco J.A. Microinjection of muscimol into raphe pallidus suppresses tachycardia associated with air stress in conscious rats. J. Physiol. 546:2003;243-250.