Familial hemophagocytic lymphohistiocytosis: A model for understanding the human machinery of cellular cytotoxicity

Cellular and Molecular Life Sciences

Volumn 69, Issue 1, 2012, Pages 29-40

  Sieni, Elena ^a   Cetica, Valentina ^a   Mastrodicasa, Elena ^b   Pende, Daniela ^c   Moretta, Lorenzo ^d   Griffiths, Gillian ^e   Aricò, Maurizio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SC di Oncoematologia Pediatrica Con Trapianto di CSE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d G GASLINI INSTITUTE   (Italy)

^e ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Cellular cytotoxicity; Hemophagocytosis; Mutation analysis; Natural killer

Indexed keywords

CYCLOSPORIN; DEXAMETHASONE; ETOPOSIDE;

CELL GRANULE; CELL MEDIATED CYTOTOXICITY; CHEDIAK HIGASHI SYNDROME; CLINICAL FEATURE; CYTOTOXIC T LYMPHOCYTE; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE MODEL; GENE MAPPING; GENE MUTATION; GENETIC DISORDER; GENETIC IDENTIFICATION; GRISCELLI SYNDROME; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HUMAN; IMMUNE DEFICIENCY; LYMPHOPROLIFERATIVE DISEASE; MACROPHAGE ACTIVATION SYNDROME; MUTATIONAL ANALYSIS; NATURAL KILLER CELL; OCULAR ALBINISM; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; REVIEW; TREATMENT OUTCOME; X CHROMOSOME LINKED DISORDER;

ANIMALS; CHEDIAK-HIGASHI SYNDROME; CYTOPLASMIC GRANULES; CYTOTOXICITY, IMMUNOLOGIC; HERMANSKI-PUDLAK SYNDROME; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; LYMPHOPROLIFERATIVE DISORDERS; MACROPHAGE ACTIVATION SYNDROME; MEMBRANE PROTEINS; MICE; MUNC18 PROTEINS; NATURAL KILLER T-CELLS; PIEBALDISM; PORE FORMING CYTOTOXIC PROTEINS; QA-SNARE PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84856222286     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0835-y     Document Type: Review

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