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Volumn 31, Issue 8, 2010, Pages 295-302

How do SAP family deficiencies compromise immunity?

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE SHP; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN; SIGNAL PEPTIDE;

EID: 77955272811     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2010.05.008     Document Type: Review
Times cited : (35)

References (62)
  • 1
    • 36049042916 scopus 로고    scopus 로고
    • Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes
    • Veillette A., et al. Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes. Immunity 2007, 27:698-710.
    • (2007) Immunity , vol.27 , pp. 698-710
    • Veillette, A.1
  • 2
    • 33244455863 scopus 로고    scopus 로고
    • Immune regulation by SLAM family receptors and SAP-related adaptors
    • Veillette A. Immune regulation by SLAM family receptors and SAP-related adaptors. Nat. Rev. Immunol. 2006, 6:56-66.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 56-66
    • Veillette, A.1
  • 3
    • 34247892632 scopus 로고    scopus 로고
    • Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules
    • Ma C.S., et al. Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu. Rev. Immunol. 2007, 25:337-379.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 337-379
    • Ma, C.S.1
  • 4
    • 58149099175 scopus 로고    scopus 로고
    • SLAM receptors and SAP influence lymphocyte interactions, development and function
    • Schwartzberg P.L., et al. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat. Rev. Immunol. 2009, 9:39-46.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 39-46
    • Schwartzberg, P.L.1
  • 5
    • 17344372694 scopus 로고    scopus 로고
    • Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
    • Coffey A.J., et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat. Genet. 1998, 20:129-135.
    • (1998) Nat. Genet. , vol.20 , pp. 129-135
    • Coffey, A.J.1
  • 6
    • 0032190081 scopus 로고    scopus 로고
    • The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
    • Sayos J., et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 1998, 395:462-469.
    • (1998) Nature , vol.395 , pp. 462-469
    • Sayos, J.1
  • 7
    • 13144278345 scopus 로고    scopus 로고
    • Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
    • Nichols K.E., et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:13765-13770.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 13765-13770
    • Nichols, K.E.1
  • 8
    • 20144387328 scopus 로고    scopus 로고
    • Regulation of NKT cell development by SAP, the protein defective in XLP
    • Nichols K.E., et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat. Med. 2005, 11:340-345.
    • (2005) Nat. Med. , vol.11 , pp. 340-345
    • Nichols, K.E.1
  • 9
    • 0035912823 scopus 로고    scopus 로고
    • Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP
    • Czar M.J., et al. Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:7449-7454.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 7449-7454
    • Czar, M.J.1
  • 10
    • 0035350808 scopus 로고    scopus 로고
    • SAP controls T cell responses to virus and terminal differentiation of TH2 cells
    • Wu C., et al. SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nat. Immunol. 2001, 2:410-414.
    • (2001) Nat. Immunol. , vol.2 , pp. 410-414
    • Wu, C.1
  • 11
    • 0141535212 scopus 로고    scopus 로고
    • Mice deficient in the X-linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus-68 and hypo-gammaglobulinemia
    • Yin L., et al. Mice deficient in the X-linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus-68 and hypo-gammaglobulinemia. J. Med. Virol. 2003, 71:446-455.
    • (2003) J. Med. Virol. , vol.71 , pp. 446-455
    • Yin, L.1
  • 12
    • 22344436371 scopus 로고    scopus 로고
    • Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
    • Bloch-Queyrat C., et al. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J. Exp. Med. 2005, 202:181-192.
    • (2005) J. Exp. Med. , vol.202 , pp. 181-192
    • Bloch-Queyrat, C.1
  • 13
    • 8444231176 scopus 로고    scopus 로고
    • Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation
    • Davidson D., et al. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity. 2004, 21:707-717.
    • (2004) Immunity. , vol.21 , pp. 707-717
    • Davidson, D.1
  • 14
    • 15444374149 scopus 로고    scopus 로고
    • Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
    • Pasquier B., et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J. Exp. Med. 2005, 201:695-701.
    • (2005) J. Exp. Med. , vol.201 , pp. 695-701
    • Pasquier, B.1
  • 15
    • 14844339362 scopus 로고    scopus 로고
    • Signaling lymphocytic activation molecule-associated protein controls NKT cell functions
    • Chung B., et al. Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J. Immunol. 2005, 174:3153-3157.
    • (2005) J. Immunol. , vol.174 , pp. 3153-3157
    • Chung, B.1
  • 16
    • 69049110783 scopus 로고    scopus 로고
    • Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
    • Dong Z., et al. Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nat. Immunol. 2009, 10:973-980.
    • (2009) Nat. Immunol. , vol.10 , pp. 973-980
    • Dong, Z.1
  • 17
    • 27144508418 scopus 로고    scopus 로고
    • Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
    • Roncagalli R., et al. Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat. Immunol. 2005, 6:1002-1010.
    • (2005) Nat. Immunol. , vol.6 , pp. 1002-1010
    • Roncagalli, R.1
  • 18
    • 2442466916 scopus 로고    scopus 로고
    • The cell surface receptor SLAM controls T cell and macrophage functions
    • Wang N., et al. The cell surface receptor SLAM controls T cell and macrophage functions. J. Exp. Med. 2004, 199:1255-1264.
    • (2004) J. Exp. Med. , vol.199 , pp. 1255-1264
    • Wang, N.1
  • 19
    • 20844439884 scopus 로고    scopus 로고
    • Cutting Edge: The SLAM family receptor Ly108 controls T cell and neutrophil functions
    • Howie D., et al. Cutting Edge: The SLAM family receptor Ly108 controls T cell and neutrophil functions. J. Immunol. 2005, 174:5931-5935.
    • (2005) J. Immunol. , vol.174 , pp. 5931-5935
    • Howie, D.1
  • 20
    • 29644441040 scopus 로고    scopus 로고
    • Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient Mice
    • Graham D.B., et al. Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient Mice. J Immunol. 2006, 176:291-300.
    • (2006) J Immunol. , vol.176 , pp. 291-300
    • Graham, D.B.1
  • 21
    • 2442428477 scopus 로고    scopus 로고
    • 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer Ccells
    • Lee K.M., et al. 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer Ccells. J Exp Med 2004, 199:1245-1254.
    • (2004) J Exp Med , vol.199 , pp. 1245-1254
    • Lee, K.M.1
  • 22
    • 60749124123 scopus 로고    scopus 로고
    • Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
    • Cruz-Munoz M.E., et al. Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat. Immunol. 2009, 10:297-305.
    • (2009) Nat. Immunol. , vol.10 , pp. 297-305
    • Cruz-Munoz, M.E.1
  • 23
    • 76949091588 scopus 로고    scopus 로고
    • Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    • Cannons J.L., et al. Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity. 2010, 32:253-265.
    • (2010) Immunity. , vol.32 , pp. 253-265
    • Cannons, J.L.1
  • 24
    • 77955272838 scopus 로고    scopus 로고
    • SLAM-family receptors: immune regulators with or without SAP-family adaptors
    • Veillette A. SLAM-family receptors: immune regulators with or without SAP-family adaptors. Cold Spring Harb. Perspect. Biol. 2010, 2:a002469.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2
    • Veillette, A.1
  • 25
    • 0034618065 scopus 로고    scopus 로고
    • X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
    • Parolini S., et al. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. J. Exp. Med. 2000, 192:337-346.
    • (2000) J. Exp. Med. , vol.192 , pp. 337-346
    • Parolini, S.1
  • 26
    • 0033564638 scopus 로고    scopus 로고
    • Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
    • Tangye S.G., et al. Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J. Immunol. 1999, 162:6981-6985.
    • (1999) J. Immunol. , vol.162 , pp. 6981-6985
    • Tangye, S.G.1
  • 27
    • 0033563218 scopus 로고    scopus 로고
    • CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis
    • Mikhalap S.V., et al. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. J. Immunol. 1999, 162:5719-5727.
    • (1999) J. Immunol. , vol.162 , pp. 5719-5727
    • Mikhalap, S.V.1
  • 28
    • 0034889004 scopus 로고    scopus 로고
    • Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product
    • Latour S., et al. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat. Immunol. 2001, 2:681-690.
    • (2001) Nat. Immunol. , vol.2 , pp. 681-690
    • Latour, S.1
  • 29
    • 0035890037 scopus 로고    scopus 로고
    • Cutting edge: activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family
    • Bouchon A., et al. Cutting edge: activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. J. Immunol. 2001, 167:5517-5521.
    • (2001) J. Immunol. , vol.167 , pp. 5517-5521
    • Bouchon, A.1
  • 30
    • 0037322612 scopus 로고    scopus 로고
    • Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation
    • Latour S., et al. Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat. Cell Biol. 2003, 5:149-154.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 149-154
    • Latour, S.1
  • 31
    • 0037320641 scopus 로고    scopus 로고
    • SAP couples Fyn to SLAM immune receptors
    • Chan B., et al. SAP couples Fyn to SLAM immune receptors. Nat. Cell Biol. 2003, 5:155-160.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 155-160
    • Chan, B.1
  • 32
    • 53149083028 scopus 로고    scopus 로고
    • Differential requirement for the SAP-Fyn interaction during NK T cell development and function
    • Nunez-Cruz S., et al. Differential requirement for the SAP-Fyn interaction during NK T cell development and function. J. Immunol. 2008, 181:2311-2320.
    • (2008) J. Immunol. , vol.181 , pp. 2311-2320
    • Nunez-Cruz, S.1
  • 33
    • 0032723181 scopus 로고    scopus 로고
    • The Src family tyrosine kinase Fyn regulates natural killer T cell development
    • Gadue P., et al. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J. Exp. Med. 1999, 190:1189-1196.
    • (1999) J. Exp. Med. , vol.190 , pp. 1189-1196
    • Gadue, P.1
  • 34
    • 33745032268 scopus 로고    scopus 로고
    • SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation
    • Cannons J.L., et al. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J. Exp. Med. 2006, 203:1551-1565.
    • (2006) J. Exp. Med. , vol.203 , pp. 1551-1565
    • Cannons, J.L.1
  • 35
    • 33749243738 scopus 로고    scopus 로고
    • The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation
    • Gu C., et al. The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:14447-14452.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 14447-14452
    • Gu, C.1
  • 36
    • 56949098139 scopus 로고    scopus 로고
    • The XLP syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation
    • Li C., et al. The XLP syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation. Cell Signal. 2009, 21:111-119.
    • (2009) Cell Signal. , vol.21 , pp. 111-119
    • Li, C.1
  • 37
    • 69949166503 scopus 로고    scopus 로고
    • Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1
    • Clarkson N.G., Brown M.H. Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1. J. Biol. Chem. 2009, 284:24725-24734.
    • (2009) J. Biol. Chem. , vol.284 , pp. 24725-24734
    • Clarkson, N.G.1    Brown, M.H.2
  • 38
    • 34548512477 scopus 로고    scopus 로고
    • Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase
    • Clarkson N.G., et al. Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase. J. Biol. Chem. 2007, 282:25385-25394.
    • (2007) J. Biol. Chem. , vol.282 , pp. 25385-25394
    • Clarkson, N.G.1
  • 39
    • 11144299492 scopus 로고    scopus 로고
    • NK cell recognition
    • Lanier L.L. NK cell recognition. Annu. Rev. Immunol. 2005, 23:225-274.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 225-274
    • Lanier, L.L.1
  • 40
    • 9444249908 scopus 로고    scopus 로고
    • Natural killer cell signaling pathways
    • Vivier E., et al. Natural killer cell signaling pathways. Science 2004, 306:1517-1519.
    • (2004) Science , vol.306 , pp. 1517-1519
    • Vivier, E.1
  • 41
    • 0027244760 scopus 로고
    • A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells
    • Garni-Wagner B.A., et al. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J. Immunol. 1993, 151:60-70.
    • (1993) J. Immunol. , vol.151 , pp. 60-70
    • Garni-Wagner, B.A.1
  • 42
    • 0035817326 scopus 로고    scopus 로고
    • NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease
    • Bottino C., et al. NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J Exp. Med. 2001, 194:235-246.
    • (2001) J Exp. Med. , vol.194 , pp. 235-246
    • Bottino, C.1
  • 43
    • 25844464180 scopus 로고    scopus 로고
    • Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
    • Bryceson Y.T., et al. Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. J. Exp. Med. 2005, 202:1001-1012.
    • (2005) J. Exp. Med. , vol.202 , pp. 1001-1012
    • Bryceson, Y.T.1
  • 44
    • 0033729573 scopus 로고    scopus 로고
    • Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
    • Nakajima H., et al. Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity. Eur. J. Immunol. 2000, 30:3309-3318.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3309-3318
    • Nakajima, H.1
  • 45
    • 0034664724 scopus 로고    scopus 로고
    • Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
    • Tangye S.G., et al. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J. Immunol. 2000, 165:2932-2936.
    • (2000) J. Immunol. , vol.165 , pp. 2932-2936
    • Tangye, S.G.1
  • 46
    • 33645748974 scopus 로고    scopus 로고
    • Requirement of homotypic NK cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions
    • Lee K.M., et al. Requirement of homotypic NK cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood 2006, 107:3181-3188.
    • (2006) Blood , vol.107 , pp. 3181-3188
    • Lee, K.M.1
  • 47
    • 70350492504 scopus 로고    scopus 로고
    • New insights into the differentiation and function of T follicular helper cells
    • King C. New insights into the differentiation and function of T follicular helper cells. Nat. Rev. Immunol. 2009, 9:757-766.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 757-766
    • King, C.1
  • 48
    • 20144389612 scopus 로고    scopus 로고
    • Defective B cell responses in the absence of SH2D1A
    • Morra M., et al. Defective B cell responses in the absence of SH2D1A. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:4819-4823.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 4819-4823
    • Morra, M.1
  • 49
    • 39549088092 scopus 로고    scopus 로고
    • SAP expression in T cells, not in B cells, is required for humoral immunity
    • Veillette A., et al. SAP expression in T cells, not in B cells, is required for humoral immunity. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:1273-1278.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 1273-1278
    • Veillette, A.1
  • 50
    • 53649107278 scopus 로고    scopus 로고
    • SAP-controlled T-B cell interactions underlie germinal centre formation
    • Qi H., et al. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature. 2008, 455:764-769.
    • (2008) Nature. , vol.455 , pp. 764-769
    • Qi, H.1
  • 51
    • 0037448564 scopus 로고    scopus 로고
    • SAP is required for generating long-term humoral immunity
    • Crotty S., et al. SAP is required for generating long-term humoral immunity. Nature 2003, 421:282-287.
    • (2003) Nature , vol.421 , pp. 282-287
    • Crotty, S.1
  • 52
    • 56149125345 scopus 로고    scopus 로고
    • SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation
    • Kamperschroer C., et al. SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J. Immunol. 2008, 181:3994-4003.
    • (2008) J. Immunol. , vol.181 , pp. 3994-4003
    • Kamperschroer, C.1
  • 53
    • 63449096041 scopus 로고    scopus 로고
    • Follicular helper T cells are required for systemic autoimmunity
    • Linterman M.A., et al. Follicular helper T cells are required for systemic autoimmunity. J. Exp. Med. 2009, 206:561-576.
    • (2009) J. Exp. Med. , vol.206 , pp. 561-576
    • Linterman, M.A.1
  • 54
    • 77955280012 scopus 로고    scopus 로고
    • Germinal center T follicular helper cells require SLAM (CD150) for IL-4 production
    • Yusuf I., et al. Germinal center T follicular helper cells require SLAM (CD150) for IL-4 production. J Immunol. 2010, 185:190-202.
    • (2010) J Immunol. , vol.185 , pp. 190-202
    • Yusuf, I.1
  • 55
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T., et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 2004, 173:68-78.
    • (2004) J. Immunol. , vol.173 , pp. 68-78
    • Chtanova, T.1
  • 56
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa C.G., et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature. 2005, 435:452-458.
    • (2005) Nature. , vol.435 , pp. 452-458
    • Vinuesa, C.G.1
  • 57
    • 33846228857 scopus 로고    scopus 로고
    • SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase
    • McCausland M.M., et al. SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J. Immunol. 2007, 178:817-828.
    • (2007) J. Immunol. , vol.178 , pp. 817-828
    • McCausland, M.M.1
  • 58
    • 34247842744 scopus 로고    scopus 로고
    • The biology of NKT cells
    • Bendelac A., et al. The biology of NKT cells. Annu. Rev. Immunol. 2007, 25:297-336.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 297-336
    • Bendelac, A.1
  • 59
    • 0024807506 scopus 로고
    • Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
    • Veillette A., et al. Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J. Exp. Med. 1989, 170:1671-1680.
    • (1989) J. Exp. Med. , vol.170 , pp. 1671-1680
    • Veillette, A.1
  • 60
    • 36049012716 scopus 로고    scopus 로고
    • Homotypic interactions mediated by slamf1 and slamf6 receptors control NKT cell lineage development
    • Griewank K., et al. Homotypic interactions mediated by slamf1 and slamf6 receptors control NKT cell lineage development. Immunity 2007, 27:751-762.
    • (2007) Immunity , vol.27 , pp. 751-762
    • Griewank, K.1
  • 61
    • 0026612411 scopus 로고
    • Pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells
    • Stein P.L., et al. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 1992, 70:741-750.
    • (1992) Cell , vol.70 , pp. 741-750
    • Stein, P.L.1
  • 62
    • 0026669001 scopus 로고
    • Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
    • Appleby M.W., et al. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 1992, 70:751-763.
    • (1992) Cell , vol.70 , pp. 751-763
    • Appleby, M.W.1


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