Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes

Blood

Volumn 105, Issue 9, 2005, Pages 3397-3404

  Massullo, Pam ^b   Druhan, Lawrence J ^b   Bunnell, Bruce A ^b   Hunter, Melissa G ^b   Robinson, John M ^b   Marsh, Clay B ^b   Avalos, Belinda R ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; LEUKOCYTE ELASTASE;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL MEMBRANE; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; ELA2 GENE; ENDOSOME; ENZYME LOCALIZATION; GENE; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC TRANSDUCTION; GRANULOPOIESIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; MUTANT; NEUTROPENIA; PHENOTYPE; PRIORITY JOURNAL; PROMYELOCYTE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SEVERE CONGENITAL NEUTROPENIA; TRANS GOLGI NETWORK; WILD TYPE;

EID: 18244377662     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-07-2618     Document Type: Article

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