A spectrum of neuroradiological findings in children with haemophagocytic lymphohistiocytosis

Pediatric Radiology

Volumn 37, Issue 11, 2007, Pages 1110-1117

  Goo, Hyun Woo ^a   Weon, Young Cheol ^b  

^a University of Ulsan College of Medicine   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Central nervous system; CT; Haemophagocytic lymphohistiocytosis; Infants and children; MR spectroscopy; MRI

Indexed keywords

N ACETYLASPARTIC ACID;

ARTICLE; BRAIN ATROPHY; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN VENTRICLE; CHILDHOOD DISEASE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; FOLLOW UP; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HUMAN; IMAGE ANALYSIS; INFANT; MALE; NEUROLOGIC DISEASE; NEURORADIOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SYSTEMIC DISEASE; TREATMENT OUTCOME; TREATMENT RESPONSE;

BIOLOGICAL MARKERS; BRAIN; CHILD, PRESCHOOL; ENCEPHALITIS; FEMALE; HUMANS; INFANT; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTONS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 35248868303     PISSN: 03010449     EISSN: 14321998     Source Type: Journal    
DOI: 10.1007/s00247-007-0569-z     Document Type: Article

References (18)

1. Janka GE (2007) Familial and acquired hemophagocytic lymphohistiocytosis. Eur J Pediatr 166:95-109
2. Haddad E, Sulis ML, Jabado N et al (1997) Frequency and severity of central nervous system lesions in hemophagocytic lymphohistiocytosis. Blood 89:794-800
3. Henter JI, Nennesmo I (1997) Neuropathological findings and neurological symptoms in 23 children with hemophagocytic lymphohistiocytosis. J Pediatr 130:358-365
4. Fitzgerald NE, MacClain KL (2003) Imaging characteristics of hemophagocytic lymphohistiocytosis. Pediatr Radiol 33:392-401
5. Kolias SS, Ball WS, Tzika AA et al (1994) Familial erythrophagocytic lymphohistiocytosis: neuroradiologic evaluation with pathologic correlation. Radiology 192:743-754
6. Huddle DC, Rosenblum JD, Diamond CK (1994) CT and MR findings in familial erythrophagocytic lymphohistiocytosis. AJR 162:1504-1505
7. Munoz Ruano MM, Castillo M (1998) Brain CT and MR imaging in familial hemophagocytic lymphohistiocytosis. AJR 170:802
8. Takahashi S, Oki J, Miyamoto A et al (1999) Encephalopathy associated with hemophagocytic lymphohistiocytosis following rotavirus infection. Eur J Pediatr 158:133-137
9. Forbes KP, Collie DA, Parker A (2000) CNS involvement of virus-associated hemophagocytic syndrome: MR imaging appearance. AJNR 21:1248-1250
10. Shinoda J, Murase S, Takenaka K et al (2005) Isolated central nervous system hemophagocytic lymphohistiocytosis: case report. Neurosurgery 56:E187-E190
11. Ozgen B, Karli-Oguz K, Sarikaya B et al (2006) Diffusion-weighted cranial MR imaging findings in a patient with hemophagocytic syndrome. AJNR 27:1312-1314
12. Chung TW (2007) CNS involvement in hemophagocytic lymphohistiocytosis: CT and MR findings. Korean J Radiol 8:78-81
13. Kieslich M, Vecchi M, Driever PH et al (2001) Acute encephalopathy as a primary manifestation of haemophagocytic lymphohistiocytosis. Dev Med Child Neurol 43:555-558
14. Rooms L, Fitzgerald N, McClain KL (2003) Hemophagocytic lymphohistiocytosis masquerading as child abuse: presentation of three cases and review of central nervous system findings in hemophagocytic lymphohistiocytosis. Pediatrics 111:e636-e640
15. Henter JI, Arico M, Egeler RM et al (1997) HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis. Med Pediatr Oncol 28:342-347
16. Henter JI, Horne A, Arico M et al (2007) HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48:124-131
17. Goo HW, Choi CG (2003) Post-contrast FLAIR MR imaging of the brain in children: normal and abnormal intracranial enhancement. Pediatr Radiol 33:843-849
18. Sundgren PC, Geijer B, Békássy AN et al (2000) Abnormalities on brain MR images during the course of familial haemophagocytic lymphohistiocytosis in a child. Acta Radiol 41:22-26