Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Nagai, Kozo ^a   Yamamoto, Ken ^b   Fujiwara, Hiroshi ^a,c   An, Jun ^a   Ochi, Toshiki ^a   Suemori, Koichiro ^a   Yasumi, Takahiro ^d   Tauchi, Hisamichi ^a   Koh, Katsuyoshi ^e   Sato, Maho ^f   Morimoto, Akira ^g   Heike, Toshio ^d   Ishii, Eiichi ^a   Yasukawa, Masaki ^a,c  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c EHIME UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^g JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MUNC 13-4 PROTEIN; MUNC 18-2 PROTEIN; PERFORIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; MUNC18 PROTEIN; PORE FORMING CYTOTOXIC PROTEIN; PRF1 PROTEIN, HUMAN; STXBP2 PROTEIN, HUMAN; UNC13D PROTEIN, HUMAN;

ADOLESCENT; ARTICLE; CELL ACTIVITY; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DEGRANULATION; FEMALE; GENE DELETION; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ANALYSIS; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; INFANT; JAPAN; LYMPHOCYTE FUNCTION; MALE; NATURAL KILLER CELL; NEWBORN; PRESCHOOL CHILD; PROTEIN EXPRESSION; SCHOOL CHILD; CELL CULTURE; CLASSIFICATION; CYTOTOXICITY; FLOW CYTOMETRY; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL DEGRANULATION; CELLS, CULTURED; CHILD; CYTOTOXICITY, IMMUNOLOGIC; DNA MUTATIONAL ANALYSIS; FEMALE; FLOW CYTOMETRY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; INFANT, NEWBORN; JAPAN; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; MEMBRANE PROTEINS; MUNC18 PROTEINS; MUTATION; POLYMERASE CHAIN REACTION; PORE FORMING CYTOTOXIC PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 78649779989     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014173     Document Type: Article

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