메뉴 건너뛰기




Volumn 166, Issue 2, 2012, Pages 306-316

Inhibition of benzalkonium chloride-induced skin inflammation in mice by an indol-1-ylpropan-2-one inhibitor of cytosolic phospholipase A 2α

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 CARBOXYPENTANOYL) 1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 CARBOXYLIC ACID; BENZALKONIUM CHLORIDE; CALGRANULIN A; CALGRANULIN B; CLOBETASOL PROPIONATE; ENZYME INHIBITOR; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 ALPHA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84856213986     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10637.x     Document Type: Article
Times cited : (15)

References (48)
  • 1
    • 66349090778 scopus 로고    scopus 로고
    • 2 structure/function, mechanism, and signaling
    • 2 structure/function, mechanism, and signaling. J Lipid Res 2009; 50 (Suppl.): S237-42.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Burke, J.E.1    Dennis, E.A.2
  • 2
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: Advances in eicosanoid biology
    • Funk CD,. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001; 294: 1871-5.
    • (2001) Science , vol.294 , pp. 1871-1875
    • Funk, C.D.1
  • 4
  • 5
    • 0037162025 scopus 로고    scopus 로고
    • Lysophospholipids and their G protein-coupled receptors in inflammation and immunity
    • Graler MH, Goetzl EJ,. Lysophospholipids and their G protein-coupled receptors in inflammation and immunity. Biochim Biophys Acta 2002; 1582: 168-74.
    • (2002) Biochim Biophys Acta , vol.1582 , pp. 168-174
    • Graler, M.H.1    Goetzl, E.J.2
  • 6
    • 73649118166 scopus 로고    scopus 로고
    • 2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases
    • 2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases. Expert Opin Ther Pat 2010; 20: 1-18.
    • (2010) Expert Opin Ther Pat , vol.20 , pp. 1-18
    • Magrioti, V.1    Kokotos, G.2
  • 11
    • 1342324060 scopus 로고    scopus 로고
    • 2α reigns supreme in arthritis and bone resorption
    • 2α reigns supreme in arthritis and bone resorption. Trends Immunol 2004; 25: 116-19.
    • (2004) Trends Immunol , vol.25 , pp. 116-119
    • Bonventre, J.1
  • 13
    • 2942527422 scopus 로고    scopus 로고
    • 2 inhibitors - Reducing the lipophilicity of the arachidonyl chain isostere
    • 2 inhibitors-reducing the lipophilicity of the arachidonyl chain isostere. Bioorg Med Chem Lett 2004; 14: 3645-9.
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 3645-3649
    • Walters, I.1    Bennion, C.2    Connolly, S.3
  • 15
    • 66449120349 scopus 로고    scopus 로고
    • 2α inhibitors with improved physicochemical properties
    • 2α inhibitors with improved physicochemical properties. Bioorg Med Chem 2009; 17: 4383-405.
    • (2009) Bioorg Med Chem , vol.17 , pp. 4383-4405
    • Kirincich, S.J.1    Xiang, J.2    Green, N.3
  • 17
    • 45749141743 scopus 로고    scopus 로고
    • 2α inhibitors: Discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4- dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl} benzoic acid, efipladib
    • 2α inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino} ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib. J Med Chem 2008; 51: 3388-413.
    • (2008) J Med Chem , vol.51 , pp. 3388-3413
    • McKew, J.C.1    Lee, K.L.2    Shen, M.W.3
  • 18
    • 38849174860 scopus 로고    scopus 로고
    • 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy
    • 2α: optimization of in vitro potency and rat pharmacokinetics for oral efficacy. Bioorg Med Chem 2008; 16: 1345-58.
    • (2008) Bioorg Med Chem , vol.16 , pp. 1345-1358
    • Lee, K.L.1    Behnke, M.L.2    Foley, M.A.3
  • 19
    • 77649104362 scopus 로고    scopus 로고
    • 2α inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model
    • 2α inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model. Inflamm Res 2010; 59: 53-62.
    • (2010) Inflamm Res , vol.59 , pp. 53-62
    • Tai, N.1    Kuwabara, K.2    Kobayashi, M.3
  • 20
    • 0034978804 scopus 로고    scopus 로고
    • 2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models
    • 2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. J Pharmacol Exp Ther 2001; 298: 376-85.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 376-385
    • Burke, J.R.1    Davern, L.B.2    Stanley, P.L.3
  • 21
    • 43449089789 scopus 로고    scopus 로고
    • 2α inhibitor RSC-3388 on skin inflammation in mice
    • 2α inhibitor RSC-3388 on skin inflammation in mice. Pharmacology 2008; 81: 301-11.
    • (2008) Pharmacology , vol.81 , pp. 301-311
    • Yamamoto, M.1    Haruna, T.2    Imura, K.3
  • 23
    • 77954755968 scopus 로고    scopus 로고
    • 2α with reduced lipophilicity: Synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity
    • 2α with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity. J Med Chem 2010; 53: 5165-78.
    • (2010) J Med Chem , vol.53 , pp. 5165-5178
    • Drews, A.1    Bovens, S.2    Roebrock, K.3
  • 24
    • 78649861774 scopus 로고    scopus 로고
    • 2α: Effect of substituents in position 3 of the indole scaffold on inhibitory potency, metabolic stability, solubility, and bioavailability
    • 2α: effect of substituents in position 3 of the indole scaffold on inhibitory potency, metabolic stability, solubility, and bioavailability. J Med Chem 2010; 53: 8298-308.
    • (2010) J Med Chem , vol.53 , pp. 8298-8308
    • Bovens, S.1    Schulze Elfringhoff, A.2    Kaptur, M.3
  • 25
    • 0035176485 scopus 로고    scopus 로고
    • Different pathways leading to cutaneous leukocytoclastic vasculitis in mice
    • Sunderkötter C, Seeliger S, Schonlau F, et al. Different pathways leading to cutaneous leukocytoclastic vasculitis in mice. Exp Dermatol 2001; 10: 391-404.
    • (2001) Exp Dermatol , vol.10 , pp. 391-404
    • Sunderkötter, C.1    Seeliger, S.2    Schonlau, F.3
  • 26
    • 8744249915 scopus 로고    scopus 로고
    • Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis
    • Hyun E, Bolla M, Steinhoff M, et al. Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis. Br J Pharmacol 2004; 143: 618-25.
    • (2004) Br J Pharmacol , vol.143 , pp. 618-625
    • Hyun, E.1    Bolla, M.2    Steinhoff, M.3
  • 27
    • 0027182472 scopus 로고
    • MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner
    • Roth J, Burwinkel F, van den Bos C, et al. MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner. Blood 1993; 82: 1875-83.
    • (1993) Blood , vol.82 , pp. 1875-1883
    • Roth, J.1    Burwinkel, F.2    Van Den Bos, C.3
  • 28
    • 0027639996 scopus 로고
    • The contact allergens nickel chloride and cobalt chloride directly induce expression of endothelial adhesion molecules
    • Goebeler M, Roth J, Meinardus-Hager G, Sorg C,. The contact allergens nickel chloride and cobalt chloride directly induce expression of endothelial adhesion molecules. Behring Inst Mitt 1993; 92: 191-201.
    • (1993) Behring Inst Mitt , vol.92 , pp. 191-201
    • Goebeler, M.1    Roth, J.2    Meinardus-Hager, G.3    Sorg, C.4
  • 29
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
    • Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001; 25: 402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 0019158157 scopus 로고
    • A survey of transformation markers in differentiating epidermal cell lines in culture
    • Yuspa SH, Hawley-Nelson P, Koehler B, et al. A survey of transformation markers in differentiating epidermal cell lines in culture. Cancer Res 1980; 40: 4694-703.
    • (1980) Cancer Res , vol.40 , pp. 4694-4703
    • Yuspa, S.H.1    Hawley-Nelson, P.2    Koehler, B.3
  • 31
    • 67650995959 scopus 로고    scopus 로고
    • High-performance liquid chromatographic assay with fluorescence detection for the evaluation of inhibitors against fatty acid amide hydrolase
    • Forster L, Schulze Elfringhoff A, Lehr M,. High-performance liquid chromatographic assay with fluorescence detection for the evaluation of inhibitors against fatty acid amide hydrolase. Anal Bioanal Chem 2009; 394: 1679-85.
    • (2009) Anal Bioanal Chem , vol.394 , pp. 1679-1685
    • Forster, L.1    Schulze Elfringhoff, A.2    Lehr, M.3
  • 32
    • 77049087509 scopus 로고    scopus 로고
    • High-performance liquid chromatography assay with fluorescence detection for the evaluation of inhibitors against human recombinant monoacylglycerol lipase
    • Holtfrerich A, Makharadze T, Lehr M,. High-performance liquid chromatography assay with fluorescence detection for the evaluation of inhibitors against human recombinant monoacylglycerol lipase. Anal Biochem 2010; 399: 218-24.
    • (2010) Anal Biochem , vol.399 , pp. 218-224
    • Holtfrerich, A.1    Makharadze, T.2    Lehr, M.3
  • 33
    • 0021798386 scopus 로고
    • Topical glucocorticoids and suppression of contact sensitivity. A mouse bioassay of anti-inflammatory effects
    • Back O, Egelrud T,. Topical glucocorticoids and suppression of contact sensitivity. A mouse bioassay of anti-inflammatory effects. Br J Dermatol 1985; 112: 539-45.
    • (1985) Br J Dermatol , vol.112 , pp. 539-545
    • Back, O.1    Egelrud, T.2
  • 34
    • 0036153739 scopus 로고    scopus 로고
    • Topical peroxisome proliferator activated receptor-α activators reduce inflammation in irritant and allergic contact dermatitis models
    • Sheu MY, Fowler AJ, Kao J, et al. Topical peroxisome proliferator activated receptor-α activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol 2002; 118: 94-101.
    • (2002) J Invest Dermatol , vol.118 , pp. 94-101
    • Sheu, M.Y.1    Fowler, A.J.2    Kao, J.3
  • 35
    • 0030827498 scopus 로고    scopus 로고
    • A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: In vivo pharmacology
    • Meingassner JG, Grassberger M, Fahrngruber H, et al. A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology. Br J Dermatol 1997; 137: 568-76.
    • (1997) Br J Dermatol , vol.137 , pp. 568-576
    • Meingassner, J.G.1    Grassberger, M.2    Fahrngruber, H.3
  • 36
    • 0026645680 scopus 로고
    • Expression of the calcium-binding proteins MRP8 and MRP14 by early infiltrating cells in experimental contact dermatitis
    • Roth J, Sunderkötter C, Goebeler M, et al. Expression of the calcium-binding proteins MRP8 and MRP14 by early infiltrating cells in experimental contact dermatitis. Int Arch Allergy Immunol 1992; 98: 140-5.
    • (1992) Int Arch Allergy Immunol , vol.98 , pp. 140-145
    • Roth, J.1    Sunderkötter, C.2    Goebeler, M.3
  • 37
    • 77957920202 scopus 로고    scopus 로고
    • Epidermal hyperplasia and elevated HB-EGF are more prominent in retinoid dermatitis compared with irritant contact dermatitis induced by benzalkonium chloride
    • Lee JE, Chang JY, Lee SE, et al. Epidermal hyperplasia and elevated HB-EGF are more prominent in retinoid dermatitis compared with irritant contact dermatitis induced by benzalkonium chloride. Ann Dermatol 2010; 22: 290-9.
    • (2010) Ann Dermatol , vol.22 , pp. 290-299
    • Lee, J.E.1    Chang, J.Y.2    Lee, S.E.3
  • 38
    • 0343457968 scopus 로고    scopus 로고
    • Epidermal cytokines in murine cutaneous irritant responses
    • Effendy I, Loffler H, Maibach HI,. Epidermal cytokines in murine cutaneous irritant responses. J Appl Toxicol 2000; 20: 335-41.
    • (2000) J Appl Toxicol , vol.20 , pp. 335-341
    • Effendy, I.1    Loffler, H.2    Maibach, H.I.3
  • 39
    • 0028322348 scopus 로고
    • Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin
    • Wilmer JL, Burleson FG, Kayama F, et al. Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin. J Invest Dermatol 1994; 102: 915-22.
    • (1994) J Invest Dermatol , vol.102 , pp. 915-922
    • Wilmer, J.L.1    Burleson, F.G.2    Kayama, F.3
  • 40
    • 0032555773 scopus 로고    scopus 로고
    • Selective induction of cell-associated interleukin-1α in murine keratinocytes by chemical allergens
    • Corsini E, Primavera A, Marinovich M, et al. Selective induction of cell-associated interleukin-1α in murine keratinocytes by chemical allergens. Toxicology 1998; 129: 193-200.
    • (1998) Toxicology , vol.129 , pp. 193-200
    • Corsini, E.1    Primavera, A.2    Marinovich, M.3
  • 41
    • 17044392271 scopus 로고    scopus 로고
    • ERK1/2 regulates epidermal chemokine expression and skin inflammation
    • Pastore S, Mascia F, Mariotti F, et al. ERK1/2 regulates epidermal chemokine expression and skin inflammation. J Immunol 2005; 174: 5047-56.
    • (2005) J Immunol , vol.174 , pp. 5047-5056
    • Pastore, S.1    Mascia, F.2    Mariotti, F.3
  • 42
    • 77954037796 scopus 로고    scopus 로고
    • Keratinocytes determine Th1 immunity during early experimental leishmaniasis
    • Ehrchen JM, Roebrock K, Foell D, et al. Keratinocytes determine Th1 immunity during early experimental leishmaniasis. PLoS Pathog 2010; 6: e1000871.
    • (2010) PLoS Pathog , vol.6
    • Ehrchen, J.M.1    Roebrock, K.2    Foell, D.3
  • 44
    • 0030051933 scopus 로고    scopus 로고
    • Selective stimulation of cutaneous interleukin 6 expression by skin allergens
    • Holliday MR, Dearman RJ, Corsini E, et al. Selective stimulation of cutaneous interleukin 6 expression by skin allergens. J Appl Toxicol 1996; 16: 65-70.
    • (1996) J Appl Toxicol , vol.16 , pp. 65-70
    • Holliday, M.R.1    Dearman, R.J.2    Corsini, E.3
  • 47
    • 0034747079 scopus 로고    scopus 로고
    • 2 for the treatment of inflammatory skin diseases
    • 2 for the treatment of inflammatory skin diseases. Curr Opin Investig Drugs 2001; 2: 1549-52.
    • (2001) Curr Opin Investig Drugs , vol.2 , pp. 1549-1552
    • Burke, J.R.1
  • 48
    • 34848863139 scopus 로고    scopus 로고
    • Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors
    • Saario SM, Laitinen JT,. Therapeutic potential of endocannabinoid- hydrolysing enzyme inhibitors. Basic Clin Pharmacol Toxicol 2007; 101: 287-93.
    • (2007) Basic Clin Pharmacol Toxicol , vol.101 , pp. 287-293
    • Saario, S.M.1    Laitinen, J.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.