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Volumn 362, Issue 2, 2012, Pages 172-186

Redundant functions of Rac GTPases in inner ear morphogenesis

Author keywords

Cochlea; Convergent extension; Otic epithelium; Rac GTPase; Semicircular canal; Spiral ganglion

Indexed keywords

BETA CATENIN; GUANOSINE TRIPHOSPHATASE; RAC1 PROTEIN; RAC2 PROTEIN; RAC3 PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN;

EID: 84856109371     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2011.12.008     Document Type: Article
Times cited : (14)

References (74)
  • 2
    • 73949136272 scopus 로고    scopus 로고
    • Patterning and cell fate in ear development
    • Alsina B., Giraldez F., Pujades C. Patterning and cell fate in ear development. Int. J. Dev. Biol. 2009, 53:1503-1513.
    • (2009) Int. J. Dev. Biol. , vol.53 , pp. 1503-1513
    • Alsina, B.1    Giraldez, F.2    Pujades, C.3
  • 3
    • 79953070455 scopus 로고    scopus 로고
    • Connecting the ear to the brain: molecular mechanisms of auditory circuit assembly
    • Appler J.M., Goodrich L.V. Connecting the ear to the brain: molecular mechanisms of auditory circuit assembly. Prog. Neurobiol. 2011, 93:488-508.
    • (2011) Prog. Neurobiol. , vol.93 , pp. 488-508
    • Appler, J.M.1    Goodrich, L.V.2
  • 4
    • 79955508089 scopus 로고    scopus 로고
    • Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
    • Baum B., Georgiou M. Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling. J. Cell Biol. 2011, 192:907-917.
    • (2011) J. Cell Biol. , vol.192 , pp. 907-917
    • Baum, B.1    Georgiou, M.2
  • 5
    • 36049016717 scopus 로고    scopus 로고
    • Patterning and morphogenesis of the vertebrate inner ear
    • Bok J., Chang W., Wu D.K. Patterning and morphogenesis of the vertebrate inner ear. Int. J. Dev. Biol. 2007, 51:521-533.
    • (2007) Int. J. Dev. Biol. , vol.51 , pp. 521-533
    • Bok, J.1    Chang, W.2    Wu, D.K.3
  • 7
    • 0028828216 scopus 로고
    • Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells
    • Bouillet P., Chazaud C., Oulad-Abdelghani M., Dolle P., Chambon P. Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells. Dev. Dyn. 1995, 204:372-382.
    • (1995) Dev. Dyn. , vol.204 , pp. 372-382
    • Bouillet, P.1    Chazaud, C.2    Oulad-Abdelghani, M.3    Dolle, P.4    Chambon, P.5
  • 8
    • 0034669184 scopus 로고    scopus 로고
    • A fate map of chick otic cup closure reveals lineage boundaries in the dorsal otocyst
    • Brigande J.V., Iten L.E., Fekete D.M. A fate map of chick otic cup closure reveals lineage boundaries in the dorsal otocyst. Dev. Biol. 2000, 227:256-270.
    • (2000) Dev. Biol. , vol.227 , pp. 256-270
    • Brigande, J.V.1    Iten, L.E.2    Fekete, D.M.3
  • 10
    • 0036337481 scopus 로고    scopus 로고
    • The role of Math1 in inner ear development: uncoupling the establishment of the sensory primordium from hair cell fate determination
    • Chen P., Johnson J.E., Zoghbi H.Y., Segil N. The role of Math1 in inner ear development: uncoupling the establishment of the sensory primordium from hair cell fate determination. Development 2002, 129:2495-2505.
    • (2002) Development , vol.129 , pp. 2495-2505
    • Chen, P.1    Johnson, J.E.2    Zoghbi, H.Y.3    Segil, N.4
  • 11
    • 55949128465 scopus 로고    scopus 로고
    • Anoikis: a necessary death program for anchorage-dependent cells
    • Chiarugi P., Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochem. Pharmacol. 2008, 76:1352-1364.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 1352-1364
    • Chiarugi, P.1    Giannoni, E.2
  • 13
    • 11244352270 scopus 로고    scopus 로고
    • Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42
    • Chu Y.S., Thomas W.A., Eder O., Pincet F., Perez E., Thiery J.P., Dufour S. Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42. J. Cell Biol. 2004, 167:1183-1194.
    • (2004) J. Cell Biol. , vol.167 , pp. 1183-1194
    • Chu, Y.S.1    Thomas, W.A.2    Eder, O.3    Pincet, F.4    Perez, E.5    Thiery, J.P.6    Dufour, S.7
  • 14
    • 0035958923 scopus 로고    scopus 로고
    • Rac1 protects epithelial cells against anoikis
    • Coniglio S.J., Jou T.S., Symons M. Rac1 protects epithelial cells against anoikis. J. Biol. Chem. 2001, 276:28113-28120.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28113-28120
    • Coniglio, S.J.1    Jou, T.S.2    Symons, M.3
  • 17
    • 8844264528 scopus 로고    scopus 로고
    • Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation
    • Esufali S., Bapat B. Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. Oncogene 2004, 23:8260-8271.
    • (2004) Oncogene , vol.23 , pp. 8260-8271
    • Esufali, S.1    Bapat, B.2
  • 19
    • 67649528138 scopus 로고    scopus 로고
    • Collective cell migration in morphogenesis, regeneration and cancer
    • Friedl P., Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2009, 10:445-457.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 445-457
    • Friedl, P.1    Gilmour, D.2
  • 20
    • 0034805575 scopus 로고    scopus 로고
    • Otx1 null mutant mice show partial segregation of sensory epithelia comparable to lamprey ears
    • Fritzsch B., Signore M., Simeone A. Otx1 null mutant mice show partial segregation of sensory epithelia comparable to lamprey ears. Dev. Genes Evol. 2001, 211:388-396.
    • (2001) Dev. Genes Evol. , vol.211 , pp. 388-396
    • Fritzsch, B.1    Signore, M.2    Simeone, A.3
  • 22
    • 72449202697 scopus 로고    scopus 로고
    • The small GTPase Rac1 regulates auditory hair cell morphogenesis
    • Grimsley-Myers C.M., Sipe C.W., Geleoc G.S., Lu X. The small GTPase Rac1 regulates auditory hair cell morphogenesis. J. Neurosci. 2009, 29:15859-15869.
    • (2009) J. Neurosci. , vol.29 , pp. 15859-15869
    • Grimsley-Myers, C.M.1    Sipe, C.W.2    Geleoc, G.S.3    Lu, X.4
  • 23
    • 33745833345 scopus 로고    scopus 로고
    • Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly
    • Guo F., Debidda M., Yang L., Williams D.A., Zheng Y. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J. Biol. Chem. 2006, 281:18652-18659.
    • (2006) J. Biol. Chem. , vol.281 , pp. 18652-18659
    • Guo, F.1    Debidda, M.2    Yang, L.3    Williams, D.A.4    Zheng, Y.5
  • 24
    • 0030824832 scopus 로고    scopus 로고
    • Characterization of RAC3, a novel member of the Rho family
    • Haataja L., Groffen J., Heisterkamp N. Characterization of RAC3, a novel member of the Rho family. J. Biol. Chem. 1997, 272:20384-20388.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20384-20388
    • Haataja, L.1    Groffen, J.2    Heisterkamp, N.3
  • 25
    • 0037439138 scopus 로고    scopus 로고
    • Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
    • Habas R., Dawid I.B., He X. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev. 2003, 17:295-309.
    • (2003) Genes Dev. , vol.17 , pp. 295-309
    • Habas, R.1    Dawid, I.B.2    He, X.3
  • 26
    • 36148989931 scopus 로고    scopus 로고
    • Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium
    • Hatch E.P., Noyes C.A., Wang X., Wright T.J., Mansour S.L. Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development 2007, 134:3615-3625.
    • (2007) Development , vol.134 , pp. 3615-3625
    • Hatch, E.P.1    Noyes, C.A.2    Wang, X.3    Wright, T.J.4    Mansour, S.L.5
  • 27
    • 0342732880 scopus 로고    scopus 로고
    • Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures
    • Hebert J.M., McConnell S.K. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev. Biol. 2000, 222:296-306.
    • (2000) Dev. Biol. , vol.222 , pp. 296-306
    • Hebert, J.M.1    McConnell, S.K.2
  • 28
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: biochemistry and biology
    • Jaffe A.B., Hall A. Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 2005, 21:247-269.
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 29
    • 58749106826 scopus 로고    scopus 로고
    • Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors
    • James R.G., Conrad W.H., Moon R.T. Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors. Methods Mol. Biol. 2008, 468:131-144.
    • (2008) Methods Mol. Biol. , vol.468 , pp. 131-144
    • James, R.G.1    Conrad, W.H.2    Moon, R.T.3
  • 30
    • 36048968147 scopus 로고    scopus 로고
    • Shaping the mammalian auditory sensory organ by the planar cell polarity pathway
    • Kelly M., Chen P. Shaping the mammalian auditory sensory organ by the planar cell polarity pathway. Int. J. Dev. Biol. 2007, 51:535-547.
    • (2007) Int. J. Dev. Biol. , vol.51 , pp. 535-547
    • Kelly, M.1    Chen, P.2
  • 32
    • 34447550617 scopus 로고    scopus 로고
    • Journey to the grave: signaling events regulating removal of apoptotic cells
    • Kinchen J.M., Ravichandran K.S. Journey to the grave: signaling events regulating removal of apoptotic cells. J. Cell Sci. 2007, 120:2143-2149.
    • (2007) J. Cell Sci. , vol.120 , pp. 2143-2149
    • Kinchen, J.M.1    Ravichandran, K.S.2
  • 34
    • 0034615175 scopus 로고    scopus 로고
    • Cell proliferation and cell death in the developing chick inner ear: spatial and temporal patterns
    • Lang H., Bever M.M., Fekete D.M. Cell proliferation and cell death in the developing chick inner ear: spatial and temporal patterns. J. Comp. Neurol. 2000, 417:205-220.
    • (2000) J. Comp. Neurol. , vol.417 , pp. 205-220
    • Lang, H.1    Bever, M.M.2    Fekete, D.M.3
  • 35
    • 0037147757 scopus 로고    scopus 로고
    • Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear
    • Lawoko-Kerali G., Rivolta M.N., Holley M. Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear. J. Comp. Neurol. 2002, 442:378-391.
    • (2002) J. Comp. Neurol. , vol.442 , pp. 378-391
    • Lawoko-Kerali, G.1    Rivolta, M.N.2    Holley, M.3
  • 36
    • 3242799695 scopus 로고    scopus 로고
    • Programmed cell death in the development of the vertebrate inner ear
    • Leon Y., Sanchez-Galiano S., Gorospe I. Programmed cell death in the development of the vertebrate inner ear. Apoptosis 2004, 9:255-264.
    • (2004) Apoptosis , vol.9 , pp. 255-264
    • Leon, Y.1    Sanchez-Galiano, S.2    Gorospe, I.3
  • 37
    • 77954394980 scopus 로고    scopus 로고
    • The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain
    • Leone D.P., Srinivasan K., Brakebusch C., McConnell S.K. The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain. Dev. Neurobiol. 2010, 70:659-678.
    • (2010) Dev. Neurobiol. , vol.70 , pp. 659-678
    • Leone, D.P.1    Srinivasan, K.2    Brakebusch, C.3    McConnell, S.K.4
  • 38
    • 21044442881 scopus 로고    scopus 로고
    • Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
    • Lin Z., Cantos R., Patente M., Wu D.K. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Development 2005, 132:2309-2318.
    • (2005) Development , vol.132 , pp. 2309-2318
    • Lin, Z.1    Cantos, R.2    Patente, M.3    Wu, D.K.4
  • 40
    • 33646432485 scopus 로고    scopus 로고
    • E-cadherin engagement stimulates proliferation via Rac1
    • Liu W.F., Nelson C.M., Pirone D.M., Chen C.S. E-cadherin engagement stimulates proliferation via Rac1. J. Cell Biol. 2006, 173:431-441.
    • (2006) J. Cell Biol. , vol.173 , pp. 431-441
    • Liu, W.F.1    Nelson, C.M.2    Pirone, D.M.3    Chen, C.S.4
  • 41
    • 0032032016 scopus 로고    scopus 로고
    • Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia
    • Ma Q., Chen Z., del Barco Barrantes I., de la Pompa J.L., Anderson D.J. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 1998, 20:469-482.
    • (1998) Neuron , vol.20 , pp. 469-482
    • Ma, Q.1    Chen, Z.2    del Barco Barrantes, I.3    de la Pompa, J.L.4    Anderson, D.J.5
  • 43
    • 0034101672 scopus 로고    scopus 로고
    • Roles of beta-catenin in inner ear development in rat embryos
    • Matsuda M., Keino H. Roles of beta-catenin in inner ear development in rat embryos. Anat. Embryol. (Berl) 2000, 202:39-48.
    • (2000) Anat. Embryol. (Berl) , vol.202 , pp. 39-48
    • Matsuda, M.1    Keino, H.2
  • 44
    • 0030005799 scopus 로고    scopus 로고
    • The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice
    • McKay I.J., Lewis J., Lumsden A. The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice. Dev. Biol. 1996, 174:370-378.
    • (1996) Dev. Biol. , vol.174 , pp. 370-378
    • McKay, I.J.1    Lewis, J.2    Lumsden, A.3
  • 45
    • 1842457076 scopus 로고    scopus 로고
    • Cellular growth and rearrangement during the development of the mammalian organ of Corti
    • McKenzie E., Krupin A., Kelley M.W. Cellular growth and rearrangement during the development of the mammalian organ of Corti. Dev. Dyn. 2004, 229:802-812.
    • (2004) Dev. Dyn. , vol.229 , pp. 802-812
    • McKenzie, E.1    Krupin, A.2    Kelley, M.W.3
  • 46
    • 0036057032 scopus 로고    scopus 로고
    • The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway
    • Merlo G.R., Paleari L., Mantero S., Zerega B., Adamska M., Rinkwitz S., Bober E., Levi G. The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway. Dev. Biol. 2002, 248:157-169.
    • (2002) Dev. Biol. , vol.248 , pp. 157-169
    • Merlo, G.R.1    Paleari, L.2    Mantero, S.3    Zerega, B.4    Adamska, M.5    Rinkwitz, S.6    Bober, E.7    Levi, G.8
  • 47
    • 0032079370 scopus 로고    scopus 로고
    • Development of the mouse inner ear and origin of its sensory organs
    • Morsli H., Choo D., Ryan A., Johnson R., Wu D.K. Development of the mouse inner ear and origin of its sensory organs. J. Neurosci. 1998, 18:3327-3335.
    • (1998) J. Neurosci. , vol.18 , pp. 3327-3335
    • Morsli, H.1    Choo, D.2    Ryan, A.3    Johnson, R.4    Wu, D.K.5
  • 48
    • 0032993290 scopus 로고    scopus 로고
    • Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
    • Morsli H., Tuorto F., Choo D., Postiglione M.P., Simeone A., Wu D.K. Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development 1999, 126:2335-2343.
    • (1999) Development , vol.126 , pp. 2335-2343
    • Morsli, H.1    Tuorto, F.2    Choo, D.3    Postiglione, M.P.4    Simeone, A.5    Wu, D.K.6
  • 49
    • 78651387406 scopus 로고    scopus 로고
    • Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney
    • Nagalakshmi V.K., Ren Q., Pugh M.M., Valerius M.T., McMahon A.P., Yu J. Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int. 2010, 79:317-330.
    • (2010) Kidney Int. , vol.79 , pp. 317-330
    • Nagalakshmi, V.K.1    Ren, Q.2    Pugh, M.M.3    Valerius, M.T.4    McMahon, A.P.5    Yu, J.6
  • 50
    • 79955642014 scopus 로고    scopus 로고
    • Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation
    • Niessen C.M., Leckband D., Yap A.S. Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol. Rev. 2011, 91:691-731.
    • (2011) Physiol. Rev. , vol.91 , pp. 691-731
    • Niessen, C.M.1    Leckband, D.2    Yap, A.S.3
  • 51
    • 77957905916 scopus 로고    scopus 로고
    • BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst
    • Ohta S., Mansour S.L., Schoenwolf G.C. BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst. Dev. Biol. 2010, 347:369-381.
    • (2010) Dev. Biol. , vol.347 , pp. 369-381
    • Ohta, S.1    Mansour, S.L.2    Schoenwolf, G.C.3
  • 52
    • 2342510998 scopus 로고    scopus 로고
    • Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome
    • Ohyama T., Groves A.K. Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis 2004, 38:195-199.
    • (2004) Genesis , vol.38 , pp. 195-199
    • Ohyama, T.1    Groves, A.K.2
  • 53
    • 33645542086 scopus 로고    scopus 로고
    • Wnt signals mediate a fate decision between otic placode and epidermis
    • Ohyama T., Mohamed O.A., Taketo M.M., Dufort D., Groves A.K. Wnt signals mediate a fate decision between otic placode and epidermis. Development 2006, 133:865-875.
    • (2006) Development , vol.133 , pp. 865-875
    • Ohyama, T.1    Mohamed, O.A.2    Taketo, M.M.3    Dufort, D.4    Groves, A.K.5
  • 57
    • 34250371830 scopus 로고    scopus 로고
    • Cell proliferation during the early compartmentalization of the Xenopus laevis inner ear
    • Quick Q.A., Serrano E.E. Cell proliferation during the early compartmentalization of the Xenopus laevis inner ear. Int. J. Dev. Biol. 2007, 51:201-209.
    • (2007) Int. J. Dev. Biol. , vol.51 , pp. 201-209
    • Quick, Q.A.1    Serrano, E.E.2
  • 58
  • 59
    • 22344451138 scopus 로고    scopus 로고
    • Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh
    • Riccomagno M.M., Takada S., Epstein D.J. Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev. 2005, 19:1612-1623.
    • (2005) Genes Dev. , vol.19 , pp. 1612-1623
    • Riccomagno, M.M.1    Takada, S.2    Epstein, D.J.3
  • 60
    • 69449085460 scopus 로고    scopus 로고
    • Line up and listen: planar cell polarity regulation in the mammalian inner ear
    • Rida P.C., Chen P. Line up and listen: planar cell polarity regulation in the mammalian inner ear. Semin. Cell Dev. Biol. 2009, 20:978-985.
    • (2009) Semin. Cell Dev. Biol. , vol.20 , pp. 978-985
    • Rida, P.C.1    Chen, P.2
  • 61
    • 0014040729 scopus 로고
    • Development of the inner ear of the mouse: a radioautographic study of terminal mitoses
    • Ruben R.J. Development of the inner ear of the mouse: a radioautographic study of terminal mitoses. Acta Otolaryngol. Suppl. 1967, 220:221-244.
    • (1967) Acta Otolaryngol. Suppl. , vol.220 , pp. 221-244
    • Ruben, R.J.1
  • 62
    • 0035346409 scopus 로고    scopus 로고
    • The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts
    • Ruggieri R., Chuang Y.Y., Symons M. The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts. Mol. Med. 2001, 7:293-300.
    • (2001) Mol. Med. , vol.7 , pp. 293-300
    • Ruggieri, R.1    Chuang, Y.Y.2    Symons, M.3
  • 63
    • 0029953417 scopus 로고    scopus 로고
    • Pax2 contributes to inner ear patterning and optic nerve trajectory
    • Torres M., Gomez-Pardo E., Gruss P. Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 1996, 122:3381-3391.
    • (1996) Development , vol.122 , pp. 3381-3391
    • Torres, M.1    Gomez-Pardo, E.2    Gruss, P.3
  • 64
    • 33750548443 scopus 로고    scopus 로고
    • Rho GTPases and cell cycle control
    • Villalonga P., Ridley A.J. Rho GTPases and cell cycle control. Growth Factors 2006, 24:159-164.
    • (2006) Growth Factors , vol.24 , pp. 159-164
    • Villalonga, P.1    Ridley, A.J.2
  • 66
    • 1642273620 scopus 로고    scopus 로고
    • Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation
    • Welsh C.F. Rho GTPases as key transducers of proliferative signals in g1 cell cycle regulation. Breast Cancer Res. Treat. 2004, 84:33-42.
    • (2004) Breast Cancer Res. Treat. , vol.84 , pp. 33-42
    • Welsh, C.F.1
  • 67
    • 41949105179 scopus 로고    scopus 로고
    • Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling
    • Wu X., Tu X., Joeng K.S., Hilton M.J., Williams D.A., Long F. Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 2008, 133:340-353.
    • (2008) Cell , vol.133 , pp. 340-353
    • Wu, X.1    Tu, X.2    Joeng, K.S.3    Hilton, M.J.4    Williams, D.A.5    Long, F.6
  • 68
    • 0031027150 scopus 로고    scopus 로고
    • Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode
    • Xu P.X., Woo I., Her H., Beier D.R., Maas R.L. Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development 1997, 124:219-231.
    • (1997) Development , vol.124 , pp. 219-231
    • Xu, P.X.1    Woo, I.2    Her, H.3    Beier, D.R.4    Maas, R.L.5
  • 69
    • 0032842838 scopus 로고    scopus 로고
    • Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
    • Xu P.X., Adams J., Peters H., Brown M.C., Heaney S., Maas R. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat. Genet. 1999, 23:113-117.
    • (1999) Nat. Genet. , vol.23 , pp. 113-117
    • Xu, P.X.1    Adams, J.2    Peters, H.3    Brown, M.C.4    Heaney, S.5    Maas, R.6
  • 70
    • 69549101928 scopus 로고    scopus 로고
    • Myosin II regulates extension, growth and patterning in the mammalian cochlear duct
    • Yamamoto N., Okano T., Ma X., Adelstein R.S., Kelley M.W. Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development 2009, 136:1977-1986.
    • (2009) Development , vol.136 , pp. 1977-1986
    • Yamamoto, N.1    Okano, T.2    Ma, X.3    Adelstein, R.S.4    Kelley, M.W.5
  • 71
    • 30744464563 scopus 로고    scopus 로고
    • Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro
    • Zhao Y., Wang Y., Wang Z., Liu H., Shen Y., Li W., Heller S., Li H. Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro. Neuroreport 2006, 17:121-124.
    • (2006) Neuroreport , vol.17 , pp. 121-124
    • Zhao, Y.1    Wang, Y.2    Wang, Z.3    Liu, H.4    Shen, Y.5    Li, W.6    Heller, S.7    Li, H.8
  • 72
  • 73
    • 33748964769 scopus 로고    scopus 로고
    • Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear
    • Zou D., Silvius D., Rodrigo-Blomqvist S., Enerback S., Xu P.X. Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear. Dev. Biol. 2006, 298:430-441.
    • (2006) Dev. Biol. , vol.298 , pp. 430-441
    • Zou, D.1    Silvius, D.2    Rodrigo-Blomqvist, S.3    Enerback, S.4    Xu, P.X.5
  • 74
    • 54449095812 scopus 로고    scopus 로고
    • Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear
    • Zou D., Erickson C., Kim E.H., Jin D., Fritzsch B., Xu P.X. Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum. Mol. Genet. 2008, 17:3340-3356.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 3340-3356
    • Zou, D.1    Erickson, C.2    Kim, E.H.3    Jin, D.4    Fritzsch, B.5    Xu, P.X.6


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