Gbx2 is required for the morphogenesis of the mouse inner ear: A downstream candidate of hindbrain signaling

Development

Volumn 132, Issue 10, 2005, Pages 2309-2318

  Lin, Zhengshi ^a   Cantos, Raquel ^a   Patente, Maria ^a   Wu, Doris K ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

Gbx2; Hindbrain signaling; Inner ear development; Kreisler; Mouse; Otic vesicle; Otx2

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR GBX2; TRANSCRIPTION FACTOR OTX2; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COCHLEA DUCT; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOLYMPHATIC SAC; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; INNER EAR; INNER EAR MALFORMATION; MORPHOGENESIS; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RHOMBENCEPHALON; SACCULUS; SEMICIRCULAR CANAL; SIGNAL TRANSDUCTION;

ANIMALS; EAR, INNER; ENDOLYMPHATIC DUCT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MICE; MORPHOGENESIS; OTX TRANSCRIPTION FACTORS; RHOMBENCEPHALON; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 21044442881     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01804     Document Type: Article

References (54)

1. -/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development 121, 3279-3290.
2. Acampora, D., Merlo, G. R., Paleari, L., Zerega, B., Postiglione, M. P., Mantero, S., Bober, E., Barbieri, O., Simeone, A. and Levi, G. (1999). Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development 126, 3795-3809.
3. Alvarez, Y., Alonso, M. T., Vendrell, V., Zelarayan, L. C., Chamero, P., Theil, T., Bosl, M. R., Kato, S., Maconochie, M., Riethmacher, D. et al. (2003). Requirements for FGF3 and FGF10 during inner ear formation. Development 130, 6329-6338.
4. Anderson, D. W., Probst, F. J., Belyantseva, I. A., Fridell, R. A., Beyer, L., Martin, D. M., Wu, D., Kachar, B., Friedman, T. B., Raphael, Y. et al. (2000). The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells. Hum. Mol. Genet. 9, 1729-1738.
5. Ang, S. L., Jin, O., Rhinn, M., Daigle, N., Stevenson, L. and Rossant, J. (1996). A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development 122, 243-252.
6. Bok, J., Bronner-Fraser, M. and Wu, D. K. (2004). Role of hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear. Development 132, 2115-2124.
7. Bouillet, P., Chazaud, C., Oulad-Abdelghani, M., Dolle, P. and Chambon, P. (1995). Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing gene induced by retinoic acid in P19 embryonal carcinoma cells. Dev. Dyn. 204, 372-382.
8. Broccoli, V., Boncinelli, E. and Wurst, W. (1999). The caudal limit of Otx2 expression positions the isthmic organizer. Nature 401, 164-168.
9. Burton, Q., Cole, L. K., Mulheisen, M., Chang, W. and Wu, D. K. (2004). The role of Pax2 in mouse inner ear development. Dev. Biol. 272, 161-175.
10. Cantos, R., Cole, L. K., Acampora, D., Simeone, A. and Wu, D. K. (2000). Patterning of the mammalian cochlea. Proc. Natl. Acad. Sci. USA 97, 11707-11713.
11. Chiang, C., Young, K. E. and Beachy, P. A. (1995). Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex. Development 121, 3901-3912.
12. Cordes, S. P. and Barsh, G. S. (1994). The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell 79, 1025-1034.
13. Depew, M. J., Liu, J. K., Long, J. E., Presley, R., Meneses, J. J., Pedersen, R. A. and Rubenstein, J. L. (1999). Dlx5 regulates regional development of the branchial arches and sensory capsules. Development 126, 3831-3846.
14. Dottori, M., Hartley, L., Galea, M., Paxinos, G., Polizzotto, M., Kilpatrick, T., Bartlett, P. F., Murphy, M., Kontgen, F. and Boyd, A. W. (1998). EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc. Natl. Acad. Sci. USA 95, 13248-13253.
15. Dressler, G. R., Deutsch, U., Chowdhury, K., Nornes, H. O. and Gruss, P. (1990). Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development 109, 787-795.
16. Everett, L. A., Belyantseva, I. A., Noben-Trauth, K., Cantos, R., Chen, A., Thakkar, S., Hoogstraten-Miller, S., Kachar, B., Wu, D. K. and Green, E. (2001). Targeted disruption of mouse Pds provides key insight about the inner-ear defects encountered in Pendred syndrome. Hum. Mol. Genet. 10, 153-161.
17. Fekete, D. M. (1996). Cell fate specification in the inner ear. Curr Opin. Neurobiol. 6, 533-541.
18. Fekete, D. M. (1999). Development of the vertebrate ear: insights from knockouts and mutants. Trends Neurosci. 22, 263-269.
19. Giudicelli, F., Gilardi-Hebenstreit, P., Mechta-Grigoriou, F., Poquet, C. and Charnay, P. (2003). Novel activities of Mafb underlie its dual role in hindbrain segmentation and regional specification. Dev. Biol. 253, 150-162.
20. Hadrys, T., Braun, T., Rinkwitz-Brandt, S., Arnold, H. H. and Bober, E. (1998). Nkx5-1 controls semicircular canal formation in the mouse inner ear. Development 125, 33-39.
21. Hidalgo-Sanchez, M., Alvarado-Mallart, R. and Alvarez, I. S. (2000). Pax2, Otx2, Gbx2 and Fgf8 expression in early otic vesicle development. Mech. Dev. 95, 225-229.
22. Hulander, M., Kiernan, A. E., Blomqvist, S. R., Carlsson, P., Samuelsson, E. J., Johansson, B. R., Steel, K. P. and Enerback, S. (2003). Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development 130, 2013-2025.
23. Karis, A., Pata, I., van Doorninck, J. H., Grosveld, F., de Zeeuw, C. I., de Caprona, D. and Fritzsch, B. (2001). Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J. Comp. Neurol. 429, 615-630.
24. Kiernan, A. E., Nunes, F., Wu, D. K. and Fekete, D. M. (1997). The expression domain of two related homeobox genes defines a compartment in the chicken inner ear that may be involved in semicircular canal formation. Dev. Biol. 191, 215-229.
25. Kiernan, A. E., Steel, K. P. and Fekete, D. M. (2002). Development of the Mouse Inner Ear. In Mouse Development: Patterning, Morphogenesis, and Organogenesis, Vol. 1 (ed. J. Rossant and P. P. L. Tam), pp. 539-566. Orlando, FL: Academic Press.
26. Ma, Q., Chen, Z., Barrantes, I., de la Pompa, J. L. and Anderson, D. J. (1998). Neurogenin 1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20, 469-482.
27. Mahmood, R., Mason, I. J. and Morriss-Kay, G. M. (1996). Expression of Fgf-3 in relation to hindbrain segmentation, otic pit position and pharyngeal arch morphology in normal and retinoic acid-exposed mouse embryos. Anat. Embryol. 194, 13-22.
28. Mansour, S. L., Goddard, J. M. and Capecchi, M. R. (1993). Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development 117, 13-28.
29. Marin, F. and Charnay, P. (2000). Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region. Development 127, 4925-4935.
30. McKay, I. J., Lewis, J. and Lumsden, A. (1996). The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice. Dev. Biol. 174, 370-378.
31. Merlo, G. R., Paleari, L., Mantero, S., Zerega, B., Adamska, M., Rinkwitz, S., Bober, E. and Levi, G. (2002). The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway. Dev. Biol. 248, 157-169.
32. Millet, S., Campbell, K., Epstein, D. J., Losos, K., Harris, E. and Joyner, A. L. (1999). A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer. Nature 401, 161-164.
33. Morsli, H., Choo, D., Ryan, A., Johnson, R. and Wu, D. K. (1998). Development of the mouse inner ear and origin of its sensory organs. J. Neurosci. 18, 3327-3335.
34. Morsli, H., Tuorto, F., Choo, D., Postiglione, M. P., Simeone, A. and Wu, D. K. (1999). Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development 126, 2335-2343.
35. Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P. and Dolle, P. (2000). Retinoic acid synthesis and hindbrain patterning in the mouse embryo. Development 127, 75-85.
36. Pirvola, U., Spencer-Dene, B., Xing-Qun, L., Kettunen, P., Thesieff, I., Fritzsch, B., Dickson, C. and Ylikoski, J. (2000). Fgf/Fgfr-2 (IIIb) signaling is essential for inner ear morphogenesis. J. Neurosci. 20, 6125-6134.
37. Rhinn, M., Dierich, A., Shawlot, W., Behringer, R. R., le Meur, M. and Ang, S. L. (1998). Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development 125, 845-856.
38. Riccomagno, M. M., Martinu, L., Mulheisen, M., Wu, D. K. and Epstein, D. J. (2002). Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev. 16, 2365-2378.
39. Rinkwitz-Brandt, S., Justus, M., Oldenettel, I., Arnold, H. H. and Bober, E. (1995). Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development. Mech. Dev. 52, 371-381.
40. Rinkwitz-Brandt, S., Arnold, H. H. and Bober, E. (1996). Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development. Hear. Res. 99, 129-138.
41. Sham, M. H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Gupta, R. D., Whiting, J., Wilkinson, D., Charnay, P. and Krumlauf, R. (1993). The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Cell 72, 183-196.
42. Shamim, H. and Mason, I. (1998). Expression of Gbx-2 during early development of the chick embryo. Mech. Dev. 76, 157-159.
43. Su, Y. and Meng, A. (2002). The expression of gbx-2 during zebrafish embryogenesis. Mech. Dev. 113, 107-110.
44. Swiatek, P. J. and Gridley, T. (1993). Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 7, 2071-2084.
45. Theil, T., Frain, M., Gilardi-Hebenstreit, P., Flenniken, A., Charnay, P. and Wilkinson, D. G. (1998). Segmental expression of the EphA4 (Sek-1) receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20. Development 125, 443-452.
46. Theil, T., Ariza-McNaughton, L., Manzanares, M., Brodie, J., Krumlauf, R. and Wilkinson, D. G. (2002). Requirement for downregulation of kreisler during late patterning of the hindbrain. Development 129, 1477-1485.
47. Torres, M., Gomez-Pardo, E. and Gruss, P. (1996). Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122, 3381-3391.
48. Vendrell, V., Carnicero, E., Giraldez, F., Alonso, M. T. and Schimmang, T. (2000). Induction of inner ear fate by FGF3. Development 127, 2011-2019.
49. von Bubnoff, A., Schmidt, J. E. and Kimelman, D. (1996). The Xenopus laevis homeobox gene Xgbx-2 is an early marker of anteroposterior patterning in the ectoderm. Mech. Dev. 54, 149-160.
50. Wang, W., van de Water, T. and Lufkin, T. (1998). Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development 125, 621-634.
51. Wassarman, K. M., Lewandoski, M., Campbell, K., Joyner, A. L., Rubenstein, J. L., Martinez, S. and Martin, G. R. (1997). Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development 124, 2923-2934.
52. Wright, T. J. and Mansour, S. L. (2003). Fgf3 and Fgf10 are required for mouse otic placode induction. Development 130, 3379-3390.
53. Xu, P. X., Woo, I., Her, H., Beier, D. R. and Maas, R. L. (1997). Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development 124, 219-231.
54. Xu, P. X., Adams, J., Peters, H., Brown, M. C., Heaney, S. and Maas, R. (1999). Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat. Genet. 23, 113-117.