The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway

Developmental Biology

Volumn 248, Issue 1, 2002, Pages 157-169

  Merlo, Giorgio R ^a   Paleari, Laura ^b   Mantero, Stefano ^b   Zerega, Barbara ^b   Adamska, Maja ^c,d   Rinkwitz, Silke ^c   Bober, Eva ^c   Levi, Giovanni ^b,e  

^a DULBECCO TELETHON INSTITUTE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

Apoptosis; Bone morphogenetic protein 4; Dlx; Homeobox gene; Inner ear; Transcription factor

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CALRETININ;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COCHLEA; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; GENE EXPRESSION; GENE FUNCTION; HOMEOBOX; IMMUNOHISTOCHEMISTRY; INNER EAR; MORPHOGENESIS; MOUSE; NEUROEPITHELIUM; NONHUMAN; NULL ALLELE; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SACCULUS; SEMICIRCULAR CANAL; TERATOLOGY; UTRICLE; VESTIBULAR SYSTEM;

EID: 0036057032     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2002.0713     Document Type: Article

References (42)

1. Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
2. FGFs control the patterning of the inner ear but are not able to induce the full ear program
3. Ectopic noggin blocks sensory and nonsensory organ morphogenesis in the chicken inner ear
4. Sensory organ generation in the chicken inner ear: Contributions of bone morphogenetic protein-4, serrate1, and lunatic-fringe
5. Dlx5 regulates regional development of the branchial arches and sensory capsules
6. Cell fate specification in the inner ear
7. Involvement of programmed cell death in morphogenesis of the vertebrate inner ear
8. Development of the vertebrate ear: Insight from knockouts and mutants
9. Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development
10. Nkx5-1 controls semicircular canal formation in the mouse inner ear
11. Two regulatory genes, cNkx5-1 and cPax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo
12. Cell proliferation and cell death in the developing chick inner ear: Spatial and temporal patterns
13. The fate mapping of the eleventh and twelfth day mouse otocyst
14. Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation
15. Descriptive and experimental analysis of the epithelial remodeling that control semicircular canal formation in the developing mouse inner ear
16. The role of FGF-3 in early inner ear development: An analysis in normal and kreisler mutant mice
17. Multiple functions of Dlx genes
18. Development of the mouse inner ear and origin of its sensory organs
19. Otx1 and Otx2 activities are required for the normal development of the mouse inner ear
20. Apoptosis during inner ear development in human and mouse embryos: An analysis by computer-assisted three-dimensional reconstruction
21. Programmed cell death in the developing epithelium of the mouse inner ear
22. Differential expression of bone morphogenetic proteins in the developing vestibular and acustic organs
23. Role of Dlx1 and Dlx2 in proximodistal patterning of the branchial arches. Mutation of Dlx1, Dlx2, and Dlx1+Dlx2 alter morphogenesis of proximal elements derived from the first and second arches
24. Bombesin and other growth factors activate cell proliferation in chick embryo otic vesicle in culture
25. Genetic patterning of embryonic inner ear development
26. Regionalized expression of Nkx5.1, Nkx5.2, Pax2 and Sek genes during mouse inner ear development
27. Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development
28. Transcription factors and the control of inner ear development
29. netrin1 is required for semicircular canal formation in the mouse inner ear
30. Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
31. Opposing effects of bone morphogenetic proteins on neuron production and survival in the olfactory receptor neuron lineage
32. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo
33. Cloning and characterization of two members of the vertebrate Dlx gene family
34. Prx1 and Prx2 in skeletogenesis: Roles in the craniofacial region, inner ear and limbs
35. The development of the vertebrate inner ear
36. Pax2 contributes to inner ear patterning and optic nerve trajectory
37. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
38. Whole-mount in situ hybridization of vertebrate embryos
39. Bone morphogenetic protein-4 is required for mesoderm formation
40. Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism
41. Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures
42. Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker