FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis

Journal of Neuroscience

Volumn 20, Issue 16, 2000, Pages 6125-6134

  Pirvola, Ulla ^a   Spencer Dene, Bradley ^b   Xing Qun, Liang ^a   Kettunen, Päivi ^a,d   Thesleff, Irma ^a   Fritzsch, Bernd ^c   Dickson, Clive ^b   Ylikoski, Jukka ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c CREIGHTON UNIVERSITY   (United States)

^d UNIVERSITY OF BERGEN   (Norway)

Author keywords

Cochleovestibular neurons; FGF10; FGF3; FGFR 2; Gene disruption; Gene expression; Inner ear development

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; COCHLEA; CONTROLLED STUDY; EMBRYO; GENE DISRUPTION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INNER EAR; MORPHOGENESIS; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 0034663154     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-16-06125.2000     Document Type: Article

References (50)

1. Development of the cranial nerve ganglia and related nuclei
2. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
3. Fgfr2 is required for limb outgrowth and lung-branching morphogenesis
4. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
5. Role for basic fibroblast growth factor (FGF-2) in tyrosine kinase (TrkB) expression in the early development and innervation of the auditory receptor: In vitro and in situ studies
6. Studies on cell migration and axon guidance in the developing distal auditory system of the mouse
7. Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning
8. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
9. Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene
10. An important role for the IIIb isoform of fibroblast growth factor receptor-2 (FGFR-2) in mesenchymal-epithelial signalling during mouse organogenesis
11. Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system
12. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
13. Cell fate specification in the inner ear
14. Development of the vertebrate ear: Insights from knockouts and mutants
15. Involvement of programmed cell death in morphogenesis of the vertebrate inner ear
16. Hair cells and supporting cells share a common progenitor in the avian inner ear
17. Early embryology of the vertebrate ear
18. Making and breaking the innervation of the ear: Neurotrophic support during ear development and its clinical implications
19. Morphogenesis
20. Basic fibroblast growth factor affects neuronal migration and differentiation in normotypic cell cultures from the cochleovestibular ganglion of the chick embryo
21. Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland
22. Responsiveness of developing dental tissues to fibroblast growth factors: Expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9
23. Associations of FGF3 and FGF10 with signaling networks regulating tooth morphogenesis
24. Breathless, a Drosophila homolog, is essential for migration of tracheal and specific midline glial cells
25. The fate mapping of the eleventh and twelfth day mouse otocyst: An in vitro study of the sites of origin of the inner ear sensory structures
26. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
27. Receptor binding and mitogenic properties of mouse fibroblast growth factor 3. Modulation of response by heparin
28. The role of FGF-3 in early inner ear development: An analysis in normal and kreisler mutant mice
29. FGF10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila Branchless
30. Development of the mouse inner ear and orgin of its sensory organs
31. The breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration
32. Spatially and temporally restricted expression of Pax2 during murine neurogenesis
33. The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the limb bud through interaction with FGF8, an apical ectodermal factor
34. FGFs, heparan sulfate and FGFRs complex interactions essential for development
35. Receptor specificity of the fibroblast growth factor family
36. Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)
37. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis
38. Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation in the mouse lung
39. Brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the peripheral target fields of developing inner ear ganglia
40. Coordinated expression and function of neurotrophins and their receptors in the rat inner ear during target innervation
41. The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea
42. FGF-8 and its high affinity receptors are expressed in the mammalian and chick cochlea
43. FGF10 is essential for limb and lung formation
44. The embryonic and postnatal development of the inner ear of the mouse
45. Branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
46. Epithelial autonomy in the development of the inner ear of a bird embryo
47. Functions of fibroblast growth factors and their receptors
48. In situ hybridization and the three-dimensional construction of serial sections
49. Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development
50. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction