메뉴 건너뛰기




Volumn 318, Issue 4, 2012, Pages 336-349

Differential effects on cell motility, embryonic stem cell self-renewal and senescence by diverse Src kinase family inhibitors

Author keywords

Aurora kinase; Cross selectivity; Embryonic stem cells; PD173952; PP2; Src kinase; SU6656

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; AURORA A KINASE; AURORA B KINASE; AURORA C KINASE; IMATINIB; PD 173952; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 84856097900     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.12.008     Document Type: Article
Times cited : (8)

References (47)
  • 1
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases-the major drug targets of the twenty-first century?
    • Cohen P. Protein kinases-the major drug targets of the twenty-first century?. Nat. Rev. Drug Discov. 2002, 1:309-315.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 309-315
    • Cohen, P.1
  • 3
    • 3843055775 scopus 로고    scopus 로고
    • The Src family of tyrosine kinases is important for embryonic stem cell self-renewal
    • Anneren C., Cowan C.A., Melton D.A. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J. Biol. Chem. 2004, 279:31590-31598.
    • (2004) J. Biol. Chem. , vol.279 , pp. 31590-31598
    • Anneren, C.1    Cowan, C.A.2    Melton, D.A.3
  • 4
    • 0028215282 scopus 로고
    • Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells
    • Ernst M., Gearing D.P., Dunn A.R. Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells. EMBO J. 1994, 13:1574-1584.
    • (1994) EMBO J. , vol.13 , pp. 1574-1584
    • Ernst, M.1    Gearing, D.P.2    Dunn, A.R.3
  • 5
    • 27544453151 scopus 로고    scopus 로고
    • SRC family kinase activity is required for murine embryonic stem cell growth and differentiation
    • Meyn M.A., Schreiner S.J., Dumitrescu T.P., Nau G.J., Smithgall T.E. SRC family kinase activity is required for murine embryonic stem cell growth and differentiation. Mol. Pharmacol. 2005, 68:1320-1330.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1320-1330
    • Meyn, M.A.1    Schreiner, S.J.2    Dumitrescu, T.P.3    Nau, G.J.4    Smithgall, T.E.5
  • 6
    • 73349084621 scopus 로고    scopus 로고
    • Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells
    • Meyn M.A., Smithgall T.E. Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. Sci. Signal. 2009, 2:ra64.
    • (2009) Sci. Signal. , vol.2
    • Meyn, M.A.1    Smithgall, T.E.2
  • 7
    • 0001884951 scopus 로고
    • Smith Culture and differentiation of embryonic stem cells
    • Smith Culture and differentiation of embryonic stem cells. Methods Cell Sci. 1991, 13:89-94.
    • (1991) Methods Cell Sci. , vol.13 , pp. 89-94
  • 8
    • 0033522510 scopus 로고    scopus 로고
    • Src family kinases are required for integrin but not PDGFR signal transduction
    • Klinghoffer R.A., Sachsenmaier C., Cooper J.A., Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 1999, 18:2459-2471.
    • (1999) EMBO J. , vol.18 , pp. 2459-2471
    • Klinghoffer, R.A.1    Sachsenmaier, C.2    Cooper, J.A.3    Soriano, P.4
  • 10
    • 14644422293 scopus 로고    scopus 로고
    • Increased stability of the p16 mRNA with replicative senescence
    • Wang W., Martindale J.L., Yang X., Chrest F.J., Gorospe M. Increased stability of the p16 mRNA with replicative senescence. EMBO Rep. 2005, 6:158-164.
    • (2005) EMBO Rep. , vol.6 , pp. 158-164
    • Wang, W.1    Martindale, J.L.2    Yang, X.3    Chrest, F.J.4    Gorospe, M.5
  • 11
    • 34248517506 scopus 로고    scopus 로고
    • Human B lymphocytes and non-Hodgkin's lymphoma cells become polyploid in response to the protein kinase inhibitor SU6656
    • Dussault N., Simard C., Neron S., Cote S. Human B lymphocytes and non-Hodgkin's lymphoma cells become polyploid in response to the protein kinase inhibitor SU6656. Blood Cells Mol. Dis. 2007, 39:130-134.
    • (2007) Blood Cells Mol. Dis. , vol.39 , pp. 130-134
    • Dussault, N.1    Simard, C.2    Neron, S.3    Cote, S.4
  • 12
    • 56049113521 scopus 로고    scopus 로고
    • Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase
    • Kaminska J., Klimczak-Jajor E., Skierski J., Bany-Laszewicz U. Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase. Acta Biochim. Pol. 2008, 55:499-506.
    • (2008) Acta Biochim. Pol. , vol.55 , pp. 499-506
    • Kaminska, J.1    Klimczak-Jajor, E.2    Skierski, J.3    Bany-Laszewicz, U.4
  • 13
    • 18544379794 scopus 로고    scopus 로고
    • Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656
    • Lannutti B.J., Blake N., Gandhi M.J., Reems J.A., Drachman J.G. Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656. Blood 2005, 105:3875-3878.
    • (2005) Blood , vol.105 , pp. 3875-3878
    • Lannutti, B.J.1    Blake, N.2    Gandhi, M.J.3    Reems, J.A.4    Drachman, J.G.5
  • 14
    • 33846988313 scopus 로고    scopus 로고
    • Roles of Aurora kinases in mitosis and tumorigenesis
    • Fu J., Bian M., Jiang Q., Zhang C. Roles of Aurora kinases in mitosis and tumorigenesis. Mol. Cancer Res. 2007, 5:1-10.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 1-10
    • Fu, J.1    Bian, M.2    Jiang, Q.3    Zhang, C.4
  • 15
    • 0037018844 scopus 로고    scopus 로고
    • Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis
    • Kallio M.J., McCleland M.L., Stukenberg P.T., Gorbsky G.J. Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr. Biol. 2002, 12:900-905.
    • (2002) Curr. Biol. , vol.12 , pp. 900-905
    • Kallio, M.J.1    McCleland, M.L.2    Stukenberg, P.T.3    Gorbsky, G.J.4
  • 17
    • 79953149145 scopus 로고    scopus 로고
    • Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF
    • Tamm C., Bower N., Anneren C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci 2011, 124:1136-1144.
    • (2011) J Cell Sci , vol.124 , pp. 1136-1144
    • Tamm, C.1    Bower, N.2    Anneren, C.3
  • 19
    • 16644386693 scopus 로고    scopus 로고
    • Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia
    • Lee M., Kim J.Y., Koh W.S. Apoptotic effect of PP2 a Src tyrosine kinase inhibitor, in murine B cell leukemia. J. Cell. Biochem. 2004, 93:629-638.
    • (2004) J. Cell. Biochem. , vol.93 , pp. 629-638
    • Lee, M.1    Kim, J.Y.2    Koh, W.S.3
  • 20
    • 0035992434 scopus 로고    scopus 로고
    • Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis
    • Nam J.S., Ino Y., Sakamoto M., Hirohashi S. Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Clin. Cancer Res. 2002, 8:2430-2436.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2430-2436
    • Nam, J.S.1    Ino, Y.2    Sakamoto, M.3    Hirohashi, S.4
  • 22
    • 0038813693 scopus 로고    scopus 로고
    • The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases
    • Tatton L., Morley G.M., Chopra R., Khwaja A. The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. J. Biol. Chem. 2003, 278:4847-4853.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4847-4853
    • Tatton, L.1    Morley, G.M.2    Chopra, R.3    Khwaja, A.4
  • 23
    • 0036736514 scopus 로고    scopus 로고
    • Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors
    • Dorsey J.F., Cunnick J.M., Lanehart R., Huang M., Kraker A.J., Bhalla K.N., Jove R., Wu J. Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors. Leukemia 2002, 16:1589-1595.
    • (2002) Leukemia , vol.16 , pp. 1589-1595
    • Dorsey, J.F.1    Cunnick, J.M.2    Lanehart, R.3    Huang, M.4    Kraker, A.J.5    Bhalla, K.N.6    Jove, R.7    Wu, J.8
  • 25
    • 0034142381 scopus 로고    scopus 로고
    • Core histone N-termini play an essential role in mitotic chromosome condensation
    • de la Barre A.E., Gerson V., Gout S., Creaven M., Allis C.D., Dimitrov S. Core histone N-termini play an essential role in mitotic chromosome condensation. EMBO J. 2000, 19:379-391.
    • (2000) EMBO J. , vol.19 , pp. 379-391
    • de la Barre, A.E.1    Gerson, V.2    Gout, S.3    Creaven, M.4    Allis, C.D.5    Dimitrov, S.6
  • 26
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • Nigg E.A. Mitotic kinases as regulators of cell division and its checkpoints. Nat. Rev. Mol. Cell Biol. 2001, 2:21-32.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 21-32
    • Nigg, E.A.1
  • 27
    • 0033515426 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 is required for proper chromosome condensation and segregation
    • Wei Y., Yu L., Bowen J., Gorovsky M.A., Allis C.D. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 1999, 97:99-109.
    • (1999) Cell , vol.97 , pp. 99-109
    • Wei, Y.1    Yu, L.2    Bowen, J.3    Gorovsky, M.A.4    Allis, C.D.5
  • 28
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson I.B., Broude E.V., Chang B.D. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist. Updat. 2001, 4:303-313.
    • (2001) Drug Resist. Updat. , vol.4 , pp. 303-313
    • Roninson, I.B.1    Broude, E.V.2    Chang, B.D.3
  • 30
    • 24744454582 scopus 로고    scopus 로고
    • Senescence comes of age
    • Narita M., Lowe S.W. Senescence comes of age. Nat. Med. 2005, 11:920-922.
    • (2005) Nat. Med. , vol.11 , pp. 920-922
    • Narita, M.1    Lowe, S.W.2
  • 31
    • 33746931268 scopus 로고    scopus 로고
    • Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells
    • Hau P.M., Siu W.Y., Wong N., Lai P.B., Poon R.Y. Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells. FEBS Lett. 2006, 580:4727-4736.
    • (2006) FEBS Lett. , vol.580 , pp. 4727-4736
    • Hau, P.M.1    Siu, W.Y.2    Wong, N.3    Lai, P.B.4    Poon, R.Y.5
  • 33
    • 34250773487 scopus 로고    scopus 로고
    • Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells
    • Tsuno T., Natsume A., Katsumata S., Mizuno M., Fujita M., Osawa H., Nakahara N., Wakabayashi T., Satoh Y., Inagaki M., Yoshida J. Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells. J. Neurooncol. 2007, 83:249-258.
    • (2007) J. Neurooncol. , vol.83 , pp. 249-258
    • Tsuno, T.1    Natsume, A.2    Katsumata, S.3    Mizuno, M.4    Fujita, M.5    Osawa, H.6    Nakahara, N.7    Wakabayashi, T.8    Satoh, Y.9    Inagaki, M.10    Yoshida, J.11
  • 36
    • 0035890906 scopus 로고    scopus 로고
    • Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells
    • Abu-Ghazaleh R., Kabir J., Jia H., Lobo M., Zachary I. Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem. J. 2001, 360:255-264.
    • (2001) Biochem. J. , vol.360 , pp. 255-264
    • Abu-Ghazaleh, R.1    Kabir, J.2    Jia, H.3    Lobo, M.4    Zachary, I.5
  • 38
    • 34548825949 scopus 로고    scopus 로고
    • C-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration
    • Sossey-Alaoui K., Li X., Cowell J.K. c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. J. Biol. Chem. 2007, 282:26257-26265.
    • (2007) J. Biol. Chem. , vol.282 , pp. 26257-26265
    • Sossey-Alaoui, K.1    Li, X.2    Cowell, J.K.3
  • 39
    • 0034816347 scopus 로고    scopus 로고
    • Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration
    • Yu J., Moon A., Kim H.R. Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration. Biochem. Biophys. Res. Commun. 2001, 282:697-700.
    • (2001) Biochem. Biophys. Res. Commun. , vol.282 , pp. 697-700
    • Yu, J.1    Moon, A.2    Kim, H.R.3
  • 40
    • 11344254134 scopus 로고    scopus 로고
    • Beta1-integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases
    • Velling T., Nilsson S., Stefansson A., Johansson S. Beta1-integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases. EMBO Rep. 2004, 5:901-905.
    • (2004) EMBO Rep. , vol.5 , pp. 901-905
    • Velling, T.1    Nilsson, S.2    Stefansson, A.3    Johansson, S.4
  • 41
    • 78650902018 scopus 로고    scopus 로고
    • PI3-kinase p110alpha mediates beta1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading
    • Zeller K.S., Idevall-Hagren O., Stefansson A., Velling T., Jackson S.P., Downward J., Tengholm A., Johansson S. PI3-kinase p110alpha mediates beta1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading. Cell. Signal. 2010, 22:1838-1848.
    • (2010) Cell. Signal. , vol.22 , pp. 1838-1848
    • Zeller, K.S.1    Idevall-Hagren, O.2    Stefansson, A.3    Velling, T.4    Jackson, S.P.5    Downward, J.6    Tengholm, A.7    Johansson, S.8
  • 42
    • 57049097531 scopus 로고    scopus 로고
    • The Hippo-YAP pathway: new connections between regulation of organ size and cancer
    • Zhao B., Lei Q.Y., Guan K.L. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr. Opin. Cell Biol. 2008, 20:638-646.
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 638-646
    • Zhao, B.1    Lei, Q.Y.2    Guan, K.L.3
  • 43
    • 60849138138 scopus 로고    scopus 로고
    • Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
    • Ota M., Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 2008, 135:4059-4069.
    • (2008) Development , vol.135 , pp. 4059-4069
    • Ota, M.1    Sasaki, H.2
  • 44
  • 45
    • 0028997651 scopus 로고
    • Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain
    • Sudol M., Bork P., Einbond A., Kastury K., Druck T., Negrini M., Huebner K., Lehman D. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J. Biol. Chem. 1995, 270:14733-14741.
    • (1995) J. Biol. Chem. , vol.270 , pp. 14733-14741
    • Sudol, M.1    Bork, P.2    Einbond, A.3    Kastury, K.4    Druck, T.5    Negrini, M.6    Huebner, K.7    Lehman, D.8
  • 46
    • 39849097306 scopus 로고    scopus 로고
    • The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals
    • Zeng Q., Hong W. The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 2008, 13:188-192.
    • (2008) Cancer Cell , vol.13 , pp. 188-192
    • Zeng, Q.1    Hong, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.