Evidence for a common pharmacological interaction site on K Ca2 channels providing both selective activation and selective inhibition of the human K Ca2.1 subtype

Molecular Pharmacology

Volumn 81, Issue 2, 2012, Pages 210-219

  Hougaard, Charlotte ^a   Hammami, Sofia ^a   Eriksen, Birgitte L ^a   Sørensen, Ulrik S ^a   Jensen, Marianne L ^a   Strøbæk, Dorte ^a   Christophersen, Palle ^a  

^a NEUROSEARCH A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

[4 (2 METHOXYPHENYLCARBAMOYLOXYMETHYL) PIPERIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER]; [N (7 (1 (4 CHLORO 2 METHYLPHENOXY)ETHYL) [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YL) N' METHOXY FORMAMIDINE]; [N (7 (1 (4 TERT BUTYL PHENOXY)ETHYL) [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-Y) N' METHOXY-FORMAMIDINE]; APAMIN; ESTER; FORMAMIDINE; GW542573X; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LEIUROTOXIN I; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG POTENTIATION; HUMAN; HUMAN CELL; IC 50; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BINDING SITES; HUMANS; INHIBITORY CONCENTRATION 50; ION CHANNEL GATING; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856068484     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.074252     Document Type: Article

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