Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro- 1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: Pharmacological evidence of deep-pore gating of KCa2 channels

Molecular Pharmacology

Volumn 79, Issue 6, 2011, Pages 899-909

  Jenkins, David Paul ^a   Strøbæk, Dorte ^b   Hougaard, Charlotte ^b   Jensen, Marianne L ^b   Hummel, Rene ^b   Sørensen, Ulrik S ^b   Christophersen, Palle ^b   Wulff, Heike ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEUROSEARCH A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 2 BENZIMIDAZOLINONE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CLOTRIMAZOLE; N (BENZIMIDAZOL 2 YL) 1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINE; NS 8593; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CALCIUM CONDUCTANCE; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

1-NAPHTHYLAMINE; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; DNA PRIMERS; HUMANS; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; SEQUENCE HOMOLOGY, AMINO ACID; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 79956327044     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.069807     Document Type: Article

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