Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Eitel, Julia ^a   Meixenberger, Karolin ^a   van Laak, Claudia ^a   Orlovski, Christine ^a   Hocke, Andreas ^a   Schmeck, Bernd ^a   Hippenstiel, Stefan ^a   N'Guessan, Philippe Dje ^a   Suttorp, Norbert ^a   Opitz, Bastian ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN ASC; RAC1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CHLAMYDIAL PNEUMONIA; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROCESSING; REGULATORY MECHANISM; RNA INTERFERENCE; ANIMAL; C57BL MOUSE; CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MONOCYTE; MOUSE MUTANT; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

CHLAMYDOPHILA PNEUMONIAE;

ANIMALS; CARRIER PROTEINS; CELL LINE; CHLAMYDOPHILA PNEUMONIAE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; POLYMERASE CHAIN REACTION; RAC1 GTP-BINDING PROTEIN; RNA INTERFERENCE;

EID: 84856063664     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030379     Document Type: Article

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