Evaluation of the immunomodulatory properties in mice and in vitro anti-inflammatory activity of cycloartane type saponins from Astragalus species

Journal of Ethnopharmacology

Volumn 139, Issue 2, 2012, Pages 574-581

  Nalbantsoy, Aye ^a,c   Nesil, Tuna ^a   Yilmaz Dilsiz, Özlem ^b   Aksu, Güzide ^b   Khan, Shabana ^c   Bedir, Erdal ^a  

^a EGE UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Astragaloside VII; Astragalus; Cycloartane; Cytokines; Immune regulation; Macrophyllosaponin B; Saponin

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; MEMBRANE PROTEIN; NAG 1 PROTEIN; SAPONIN; TRANSFORMING GROWTH FACTOR BETA1; TRITERPENIC GLYCOSIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTRAGALUS PLANT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IC 50; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; MALE; MOUSE; NONHUMAN; SPLEEN; TH1 CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ASTRAGALUS PLANT; CACO-2 CELLS; CELL PROLIFERATION; CYTOKINES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GROWTH DIFFERENTIATION FACTOR 15; HT29 CELLS; HUMANS; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC FACTORS; INFLAMMATION MEDIATORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LECTINS, C-TYPE; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MACROPHAGES; MALE; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANTS, MEDICINAL; SAPONINS; SPLEEN; TRANSFECTION; TRITERPENES;

MUS;

EID: 84856015922     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.11.053     Document Type: Article

References (53)

1. K. Auyeung, P. Law, and J. Ko Astragalus saponins induce apoptosis via an ERK-independent NF-κB signaling pathway in the human hepatocellular HepG2 cell line International Journal of Molecular Medicine 23 2009 189 196
2. Z. Ayta Astragalus L A. Güner, N. Ozhatay, T. Ekim, K.H.C. Baer, Flora of Turkey and the East Aegean Islands 2000 Edinburgh University Press Edinburgh 18 pp.
3. T. Barbosa, S. Arruda, B. Cavada, T. Barbosa-Grangeiro, A.R. de Freitas, and M. Barral-Netto In vivo Lymphocyte Activation and Apoptosis by Lectins of the Diocleinae Subtribe vol. 96 2001 Memorias do Instituto Oswaldo Cruz Rio de Janeiro pp. 673-678
4. E. Bedir, I. Calis, R. Aquino, S. Piacente, and C. Pizza Secondary metabolites from the roots of Astragalus trojanus Journal of Natural Products 62 1999 563 568 (Pubitemid 29200734)
5. E. Bedir, N. Pugh, I. Calis, D.S. Pasco, and I.A. Khan Immunostimulatory effects of cycloartane-type triterpene glycosides from Astragalus species Biological and Pharmaceutical Bulletin 23 2000 834 837 (Pubitemid 30484381)
6. E. Bedir, I. Calis, and I.A. Khan Macrophyllosaponin E, a novel compound from the roots of Astragalus oleifolius Chemical and Pharmaceutical Bulletin 48 2000 1081 1083 (Pubitemid 30485412)
7. E. Bedir, I. Tatli, I. Calis, and I.A. Khan Trojanosides I-K: new cycloartane-type glycosides from the aerial parts of Astragalus trojanus Chemical and Pharmaceutical Bulletin 49 2001 1482 1486 (Pubitemid 33043284)
8. E. Bedir, I. Calis, C. Dunbar, R. Sharan, J.K. Buolamwini, and I.A. Khan Two novel cycloartane-type triterpene glycosides from the roots of Astragalus prusianus Tetrahedron 57 2001 5961 5966 (Pubitemid 32607601)
9. F. Belardelli Role of interferons and other cytokines in the regulation of the immune response Acta Pathologica Microbiologica et Immunologica Scandinavica 103 1995 161 179
10. C. Cambiaggi, M.T. Scupoli, T. Cestari, F. Gerosa, G. Carra, G. Tridente, and R.S. Acolla Constitutive expression of CD69 in interspecies T-cells hybrids and locus assignment to human chromosome 12 Immunogenetics 36 1992 117 120
11. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867 (Pubitemid 36019639)
12. P. Gariboldi, F. Pelizzoni, M. Tato, L. Verotta, N.A. El-Sebakhy, A.M. Asaad, R.M. Abdallah, and S.M. Toaima Cycloartane triterpene glycosides from Astragalus trigonus Phytochemistry 40 1995 1755 1760 (Pubitemid 3009267)
13. K. Gilbert, M. Thoman, K. Bauche, T. Pham, and W. Weigle Transforming growth factor-beta 1 induces antigen-specific unresponsiveness in naive T cells Immunological Investigations 26 1997 459 472 (Pubitemid 27305215)
14. D. Gülcemal, Ö. Alanku-alikan, A. Perrone, F. Özgöke, S. Piacente, and E. Bedir Cycloartane glycosides from Astragalus aureus Phytochemistry 72 2011 761 768
15. I. Horo, E. Bedir, A. Perrone, F. Özgöke, S. Piacente, and Ö. Alanku-alikan Triterpene glycosides from Astragalus icmadophilus Phytochemistry 71 2010 956 973
16. C.A. Janeway, P. Travers, S. Hunt, and M. Walport Immunobiology: The Immune System in Health and Disease 1997 Garland Publishing Inc. New York, USA pp. 1-26
17. Kuby T.J. Kindt, R.A. Goldsby, B.A. Osborne, J. Kuby, Immunology sixth ed. 2007 W.H. Freeman and Company New York
18. P. Lauzurica, D. Sancho, M. Torres, B. Albella, M. Marazuela, T. Merino, J.A. Bueren, A.C. Martíneza, and F. Sánchez-Madrid Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice Blood 95 2000 2312 2320 (Pubitemid 30167730)
19. K.Y. Lee, and Y.J. Jeon Macrophage activation by polysaccharide isolated from Astragalus membranaceus International Immunopharmacology 5 2005 1225 1233
20. J.L. Letterio, and A.B. Roberts Regulation of the immune response by TGF-β Annual Review of Immunology 16 1998 137 161
21. M.O. Li, Y.Y. Wan, S. Sanjabi, A.K. Robertson, and R.A. Flavell Transforming growth factor-beta regulation of immune responses Annualogy 24 2006 99 146
22. D. Lio, G. Candore, D. Cigna, C. D'Anna, G. Di Lorenzo, C. Giordano, G. Lucania, P. Mansueto, M. Melluso, M.A. Modica, and C. Caruso In vitro T cell activation in elderly individuals: failure in CD69 and CD71 expression Mechanisms of Ageing and Development 89 1996 51 58 (Pubitemid 26234077)
23. Y. Liu, Y. Ng, and K.O. Lillehei Cell mediated immunotherapy: a new approach to the treatment of malignant glioma Cancer Control 10 2003 138 147 (Pubitemid 36437820)
24. G. Ma, S.I. Khan, G. Benavides, W. Schuhly, N.H. Fischer, I. Khan, and D.S. Pasco Inhibition of NF-kappaB-mediated transcription and induction of apoptosis by melampolides and repandolides Cancer Chemotherapy and Pharmacology 60 2007 35 43 (Pubitemid 46643715)
25. A. Nalbantsoy, I. Karaboz, R. Ivanova, and I. Deliloglu-Gurhan Isolation and purification of O and H antigens from Salmonella Enteritidis as diagnostic tool Annals of Microbiology 60 2010 565 571
26. A. Nalbantsoy, T. Nesil, S. Erden,. ali, and E. Bedir Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII Journal of Ethnopharmacology 134 2011 897 903
27. M. Philip, D.A. Rowley, and H. Schreiber Inflammation as a tumor promoter in cancer induction Seminars in Cancer Biology 14 2004 433 439 (Pubitemid 39360991)
28. G. Pinchuk Immunology 2004 The McGraw-Hill Companies New York
29. L. Pistelli Secondary metabolites of genus Astragalus: structure and biological activity Atta-Ur-Rahman Studies in Natural Products Chemistry (Bioactive Natural Products, Part H) 2002 Elsevier Science B.V. Karachi 443 545
30. E. Polat, O. Caliskan-Alankus, A. Perrone, S. Piacente, and E. Bedir Cycloartane-type glycosides from Astragalus amblolepis Phytochemistry 70 2009 628 634
31. E. Polat, E. Bedir, A. Perrone, S. Piacente, and O. Alankus-Caliskan Triterpenoid saponins from Astragalus wiedemannianus Fischer Phytochemistry 71 2010 658 662
32. D.N. Quang, L. Harinantenaina, T. Nishizawa, T. Hashimoto, C. Kohchi, G.I. Soma, and Y. Asakawa Inhibition of nitric oxide production in RAW 264.7 cells by azaphilones from xylariaceous fungi Biological and Pharmaceutical Bulletin 29 2006 34 37 (Pubitemid 43036689)
33. J.L. Rios, and P.G. Waterman A review of the pharmacology and toxicology of Astragalus Phytotherapy Research 11 1997 411 418 (Pubitemid 27389299)
34. S. Romagnani Induction of TH1 and TH2 responses: a key role for the 'natural' immune response? Immunology Today 13 1992 379 381
35. D.C. Sheehan, and B.B. Hrapchak Theory and Practice of Histotechnology second ed. 1987 Battelle Memorial Institute Columbia, OH
36. K.A. Smith Interleukin-2: inception, impact, and implications Science 240 1988 1169 1176
37. V.S. Sobolev, S.I. Khan, N. Tabanca, D.E. Wedge, S.P. Manly, S.J. Cutler, M.R. Coy, J.J. Becnel, S.A. Neff, and J.B. Gloer Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids Journal of Agricultural and Food Chemistry 59 2011 1673 1682
38. D.K. Sojka, D. Bruniquel, R.H. Schwartz, and N.J. Singh IL-2 secretion by CD4+ T cells in vivo is rapid, transient, and influenced by TCR-specific competition Journal of Immunology 172 2004 6136 6143 (Pubitemid 38621218)
39. C. Sudarshan, J. Galon, Y. Zhou, and J.J. O'Shea TGF-β does not inhibit IL-12- and IL-2-induced activation of janus kinases and STATs Journal of Immunology 162 1999 2974 2981 (Pubitemid 29309326)
40. W. Tang, and G. Eisenbrand Chinese Drugs of Plant Origin 1992 Springer-Verlag Berlin
41. M. Tiemessen, S. Kunzmann, C. Schmidt-Weber, J. Garssen, C. Bruijnzeel-Koomen, E. Knol, and E. van Hoffen Transforming growth factor-beta inhibits human antigen-specific CD4+ T cell proliferation without modulating the cytokine response International Immunology 15 2003 1495 1504 (Pubitemid 37536750)
42. S.M. Wahl, D.A. Hunt, H.L. Wong, S. Dougherty, and N. McCartney-Francis Transforming growth factorbeta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation Journal of Immunology 140 1988 3026 3032
43. S. Wahl, J. Wen, and N. Moutsopoulos TGF-beta: a mobile purveyor of immune privilege Immunological Reviews 213 2006 213 227 (Pubitemid 44401503)
44. G. Wang, J. Zhao, J.W. Liu, Y.P. Huang, W. Tang, and J.J. Zhong Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo International Immunopharmacology 7 2007 864 870 (Pubitemid 46635284)
45. L.C. Wilson, S.J. Baek, A. Call, and T.E. Eling Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells International Journal of Cancer 105 2003 747 753 (Pubitemid 36706096)
46. V.K.W. Wong, H. Zhou, S.S.F. Cheung, T. Li, and L. Liu Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation Journal of Cellular Biochemistry 107 2009 303 315
47. J.A. Yang-Snyder, and E.V. Rothenberg Developmental and anatomical patterns of IL-2 gene expression in vivo in the murine thymus Developmental Immunology 3 1993 85 102
48. Z.G. Yang, H.X. Suna, and W.H. Fang Hemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice Vaccine 23 2005 5196 5203
49. W. Yejin, and W. Yanqun Inhibition of Astragalus membranaceus polysaccharides against liver cancer cell HepG2 African Journal of Microbiology Research 4 2010 2181 2183
50. E. Yesilada, E. Bedir, I. Calis, Y. Takaishi, and Y. Ohmoto Effects of triterpene saponins from Astragalus species on in vitro cytokine release Journal of Ethnopharmacology 96 2005 71 77 (Pubitemid 39575033)
51. K.S. Yeung, J. Jyothirmai Gubili, and B.R. Cassileth An evidence-based review of Astragalus membranaceus (Astragalus) for cancer patients Evidence-based Anticancer Complementary and Alternative Medicine 2011 65 84
52. H.A. Young, and K.J. Hardy Role of interferon-γ in immune cell regulation Journal of Leukocyte Biology 58 1995 373 381
53. D.H. Yu, Y.M. Bao, L.J. An, and M. Yang Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus Biomedical and Environmental Sciences 22 2009 50 54