In vitro T cell activation in elderly individuals: Failure in CD69 and CD71 expression

Mechanisms of Ageing and Development

Volumn 89, Issue 1, 1996, Pages 51-58

  Lio, Domenico ^a   Candore, Giuseppina ^a   Cigna, Diego ^a   D'Anna, Claudia ^a   Di Lorenzo, Gabriele ^b   Giordano, Carla ^b   Lucania, Gaetano ^a   Mansueto, Pasquale ^b   Melluso, Marcello ^b   Modica, Maria Assunta ^a   Caruso, Calogero ^a  

^a Istituto di Patologia Generale   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

CD69 cells; CD71 cells; Elderly; PHA; T cell activation

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD71 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 2; T LYMPHOCYTE ANTIGEN;

AGED; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0030608166     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/0047-6374(96)01726-5     Document Type: Article

References (42)

1. [1] T. Makinodan and M.B. Kay, Age influence on the immune system. Adv. Immunol., 29 (1980) 287-330.
2. [2] M.B. Kay and T. Makinodan, Relationship between aging and immune system. Prog. Allergy, 29 (1981) 134-181.
3. [3] M.L. Thoman and W.O. Weigle, The cellular and subcellular bases of immunosenescence. Adv. Immunol., 46 (1989) 221-261.
4. [4] J.M. Hefton, G.J. Darlington, B.A. Casazza and M.E. Weksler, Immunologic studies of aging, V. Impaired proliferation of PHA responsive human lymphocytes in culture. J. Immunol., 125 (1980) 1007-1010.
5. [5] D.M. Murasko, P. Weiner and D. Kaye, Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol., 70 (1987) 440-448.
6. [5] D.M. Murasko, P. Weiner and D. Kaye, Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol., 70 (1987) 440-448.
7. [6] L. Song, Y.H. Kim and R.K. Chopra, Age-related effects in T cell activation and proliferation. Exp. Gerontol., 28 (1993) 313-321.
8. [7] S. Gillis, R. Kozak, M. Durante and M.E. Weksler, Immunological studies of aging. Decreased production and response to T cell growth factor by lymphocytes from aged humans. J. Clin. Invest., 67 (1981) 937-942.
9. [8] M.L. Thoman and W.O. Weigle, Cell-mediated immunity in aged mice: an underlying lesion in IL-2 synthesis. J. Immunol., 128 (1982) 2358-2361.
10. [9] J.E. Nagel, R.K. Chopra, F.J. Chrest, M.T. McCoy, E.L. Schneider, N.J. Holbrook and W.H. Adler. Decreased proliferation, IL-2 synthesis, and IL-2 receptor expression are accompanied by decreased mRNA expression in PHA-stimulated cells from elderly donors. J. Clin. Invest. 81 (1988) 1096-1102.
11. [10] G. Candore, G. Di Lorenzo, C. Caruso, M.A. Modica, A.T. Colucci, G. Crescimanno, A. Ingrassia, G. Barbagallo Sangiorgi and A. Salerno, The effect of age on mitogen responsive T cell precursors in human beings is completely restored by interleukin-2. Mech. Ageing Dev., 63 (1992) 297-307.
12. [11] J.E. Nagel, R.K. Chopra, D.C. Powers and W.H. Adler, Effect of age on the human high affinity IL-2 receptor of PHA stimulated peripheral blood lymphocytes. Clin. Exp. Immunol., 75 (1989) 286-291.
13. [12] C. Caruso, G. Di Lorenzo, M.A. Modica, G. Candore, M.R. Portelli, G. Crescimanno, A. Ingrassia, G. Barbagallo Sangiorgi and A. Salerno, Soluble IL-2 receptor secretion defect in vitro in elderly subjects. Mech. Ageing Dev., 59 (1991) 27-35.
14. [13] P.C. Creemers, Determination of co-expression of activation antigens on proliferating CD4 +, CD4 + CD8 + and CD8 + lymphocytes subsets by dual parameter flow cytometry. J. Immunol. Methods. 97 (1987) 165-171.
15. [14] T.A. Poulton, A. Gallagher, R.C. Potts and J. Swanson Beck, Changes in activation markers and cell membranes receptors on human peripheral blood T lymphocytes during cell cycle progression after PHA stimulation. Immunology, 64 (1988) 419-425.
16. [15] G.R. Crabtee, Contigent genetic regulatory events in T lymphocyte activation. Science, 243 (1989) 355-361.
17. [16] F.H. Bach, R.L. Geller, P.J. Nelson, S. Panzer, G. Gromo, M.R. Benfield, L. Wuerards, E.R. Podack, J.C. Witson, J.P. Houchins and B.J. Alter. A "minimal signal-stepwise activation" analysis of functional maturation of T lymphocytes. Immunol. Rev., 243 (1989) 35-37.
18. [17] C.H. June. Signal transduction in T cells. Curr. Opin. Immunol., 3 (1991) 287-293.
19. [18] L.M. Neckers and J. Cossman, Transferrin receptor induction in mitogen-stimulated T lymphocytes is required for DNA synthesis and cell division and is regulated by IL-2. Proc. Natl. Acad. Sci. USA. 80 (1983) 3494-3498.
20. [19] E. Pelosi. U. Testa, F. Louache, P. Thomopoulos, G. Salvo, P. Samoggia and C. Peschle, Expression of transferrin receptors in PHA-stimulated human T-lymphocytes. Evidence for a Three-step model. J. Biochem. Chem., 261 (1986) 3036-3042.
21. [20] R. Testi. J.H. Phillips and L.L. Lanier. T cell activation via Leu-23 (CD69). J. Immunol.. 143 (1989) 1123-1128.
22. [21] S. Carrel, S. Salvi, P. Isler, C. Rapin, D. Hayoz, P. Gallay and L. Giuffre', Gp-33-38, an early human T cell activation antigen. J. Immunol. 144 (1990) 2053-2062.
23. [22] R. Testi, D. D'Ambrosio, R. De Maria and A. Santoni, The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol. Today, 15 (1994) 479-481.
24. [23] C. Giordano, R. De Maria, M. Todaro, G. Stassi, A. Mattina, P. Richiusa, G. Galluzzo, F. Panto' and A. Galluzzo, Study of T cell activation in type I diabetic subjects by cytometric analysis: antigen expression defect in vitro. J. Clin. Immunol., 13 (1993) 68-78.
25. [24] G. Candore, D. Cigna, M. Todaro, R. De Maria, G. Stassi, C. Giordano and C. Caruso, T cell activation in HLA-B8,DR3 positive individuals: early antigen expression defect in vitro. Hum. Immunol., 42 (1995) 289-294.
26. [25] R. De Maria, M. Todaro, G. Stassi, F. Di Blasi, M. Giordano, A. Galluzzo and C. Giordano, Defective TCR CD3 complex signalling in human type I Diabetes. Eur. J. Immunol., 24 (1994) 999-1002.
27. [26] R. Biselli, P.M. Matricardi, R. D'Amelio and A. Fattorossi, Multiparametric flow cytometric analysis of the kinetics of surface molecule expression after polyclonal activation of human peripheral blood T lymphocytes. Scand. J. Immunol., 35 (1992) 439-447.
28. [27] T. Makinodan, J. Lubinski and T.C. Fong, Cellular, Biochemical and molecular basis of T-cell senescence. Arch. Pathol. Lab. Med., 11 (1987) 910-914.
29. [28] R.A. Miller, The cell biology of aging: immunological models. J. Gerontol., 44 (1989) 84-88.
30. [29] X. Xu, I. Beckman, K. Dimopulos, M. Ahern and J. Bradley, Age related changes in the expression of T cell activation antigens following phytoemoagglutinin stimulation. Exp. Clin., Immunogenet., 9 (1993) 203-211.
31. [30] M. V. Hobbs, W.O. Weigle, D.J. Noonan, B.E. Torbett, R.J. MecEvilly, R.J. Koch, G.J. Cardenas, and D.N. Ernst, Patterns of cytokine gene expression by CD4 + T cells from young and old mice. J. Immunol., 150 (1993) 3602-3614.
32. [31] G. Pawelec, Molecular and cell biological studies of ageing and their application to considerations of T lymphocyte immunosenescence. Mech. Ageing Dev., 79 (1995) 1-32.
33. [32] C. Caruso, G. Candore, D. Cigna, G. Di Lorenzo, G. Sireci, F. Dieli, and A. Salerno, Cytokine production pathway in elderly. Immunol. Res., (1996) in press.
34. [33] F. Borrego, J. Pena and R. Solana, Regulation of CD69 expression on human natural killer cells: differential involvement of protein kinase C and protein tyrosine kinases. Eur. J. Immunol., 23 (1993) 1039-1042.
35. [34] G. Candore, G. Di Lorenzo, M. Melluso, D. Cigna, A.T. Colucci, M.A. Modica and C. Caruso, γ-Interferon, interleukin-4 and interleukin-6 in vitro production in old subjects. Autoimmunity, 16 (1993) 275-280.
36. [35] C. Caruso, G. Candore, A.T. Colucci and M.A. Modica, Biological significance of soluble IL-2 receptor. Mediators of inflammation, 2 (1993) 3-21.
37. + + and activation of PKC. J. Immunol., 142 (1989) 1854-1859.
38. [37] C. Giordano, F. Pantò, C. Caruso, M.A. Modica, A.M. Zambito, N. Sapienza, M.P. Amato and A. Galluzzo, Interleukin-2 and soluble IL-2 receptor secretion defect in vitro in newly diagnosed type I diabetic patients. Diabetes, 31 (1989) 310-315.
39. [38] M.A. Modica. A.M. Zambito, G. Candore and C. Caruso, Markers of T lymphocyte activation in HLA-B8,DR3 positive individuals. Immunobiology, 181 (1990)257-266.
40. [39] M.A. Modica, A.T. Colucci, G. Candore and C. Caruso, The HLA-B8,DR3 haplotype and immune response in healthy subjects. Immunol. Infect. Dis. 3 (1993) 119-127.
41. [40] G. Candore, D. Cigna, F. Gervasi, A.T. Colucci, M.A. Modica and C. Caruso, In vitro cytokine production by HLA-B8,DR3 positive subjects. Autoimmunity, 18 (1994) 121-132.
42. [41] T. Makinodan, M.P. Chang and N. Kinohara, Influence of age on cellular differentiation: a T cell model. Exp. Gerontol., 21 (1986) 241-253.