Adjuvant effects of Astragalus saponins Macrophyllosaponin B and Astragaloside VII

Journal of Ethnopharmacology

Volumn 134, Issue 3, 2011, Pages 897-903

  Nalbantsoy, Aye ^a   Nesil, Tuna ^b   Erden, Seil ^b   Çaliş, Ihsan ^c   Bedir, Erdal ^a  

^a EGE UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

^c NEAR EAST UNIVERSITY   (Turkey)

Author keywords

Adjuvant activity; Astragaloside VII; Astragalus; Cycloartane; Macrophyllosaponin B; Saponin

Indexed keywords

ASTRAGALOSIDE VII; ASTRAGALUS EXTRACT; CONCANAVALIN A; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2B; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MACROPHYLLOSAPONIN B; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; ASTRAGALUS PLANT; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOLYSIS; IMMUNIZATION; IMMUNOMODULATION; MALE; MOUSE; NONHUMAN; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY FORMATION; ASTRAGALUS PLANT; CELL PROLIFERATION; HEMOLYSIS; IMMUNITY, CELLULAR; INTERFERON-GAMMA; INTERLEUKIN-4; MALE; MICE; SAPONINS; SPLEEN;

ASTRAGALUS OLEIFOLIUS; ASTRAGALUS TROJANUS; MUS; ORYCTOLAGUS CUNICULUS;

EID: 79954414757     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2011.01.054     Document Type: Article

References (37)

1. E. Baumann, G. Stoya, A. Volkner, W. Richter, C. Lemke, and W. Linss Hemolysis of human erythrocytes with saponin affects the membrane structure Acta Histochemica 102 2000 21 35 (Pubitemid 30120643)
2. E. Bedir, I. ali, R. Aquino, S. Piacente, C. Pizza, and H. Trojanoside A novel cycloartane type glycoside from the aerial parts of Astragalus trojanus Phytochemistry 51 1999 1017 1020 (Pubitemid 29350051)
3. E. Bedir, N. Pugh, I. ali, D.S. Pasco, and I.A. Khan Immunostimulatory effects of cycloartane-type triterpene glycosides from Astragalus species Biological and Pharmaceutical Bulletin 23 2000 834 837 (Pubitemid 30484381)
4. E. Bedir, I. ali, I.A. Khan, and E. Macrophyllosaponin A novel compound from the roots of Astragalus oleifolius Chemical and Pharmaceutical Bulletin 48 2000 1081 1083 (Pubitemid 30485412)
5. E. Bedir, I.I. Tatli, I. ali, and I.A. Khan Trojanosides I-K: new cycloartane-type glycosides from the aerial parts of Astragalus trojanus Chemical and Pharmaceutical Bulletin 49 2001 1482 1486 (Pubitemid 33043284)
6. E. Bedir, I. ali, C. Dunbar, R. Sharan, J.K. Buolamwini, and I.A. Khan Two novel cycloartane-type triterpene glycosides from the roots of Astragalus prusianus Tetrahedron 57 2001 5961 5966 (Pubitemid 32607601)
7. I. Calis, M. Zor, I. Saraoglu, A. Isimer, and H. Ruegger Four novel cycloartane glycosides from Astragalus oleifolius Journal of Natural Products 59 1996 1019 1023 (Pubitemid 26408649)
8. I. Calis, A. Yuruker, D. Tasdemir, A.D. Wright, O. Sticher, Y.D. Luo, and J.M. Pezzuto Cycloartane triterpenes glycosides from the roots of Astragalus melanophrurius Planta Medica 63 1997 183 186 (Pubitemid 27196093)
9. W.S. Chan, S.S.K. Durairajan, J.H. Lu, Y. Wang, L.X. Xie, W.F. Kum, I. Koo, K.K.L. Yung, and M. Li Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture Neurochemistry International 55 2009 414 442
10. R. Edelman D.T. O'Hagan, Vaccine Adjuvants: Preparation Methods and Research Protocols 2000 Humana Press
11. Z.A. Khushbaktova, M.A. Agzamova, V.N. Syrov, N.V. Radchenko, N.M. Mirsalikhova, and F.T. Umarova Influence of cycloartanes from plants of the genus Astragalus and their synthetic analogs on the contractive function of the myocardium and the activity of Na K-ATPase Chemistry of Natural Compounds 30 1994 469 473
12. Y. Luo, Z. Qin, Z. Hong, X. Zhang, D. Ding, J.H. Fu, W.D. Zhang, and J. Chen Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia Neuroscience Letters 363 2004 218 223 (Pubitemid 38746516)
13. D.J. Marciani, J.B. Press, R.C. Reynolds, A.K. Pathak, V. Pathak, L.E. Gundy, J.T. Farmer, M.S. Koratich, and R.D. May Development of semi synthetic triterpenoid saponin derivatives with immune stimulating activity Vaccine 18 2000 3141 3151 (Pubitemid 30345696)
14. T.R. Mosmann, and R.L. Coffman Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties Annual Review of Immunology 7 1989 145 173 (Pubitemid 19138011)
15. A. Nalbantsoy, I. Karaboz, R. Ivanova, and I. Deliloglu-Gurhan Isolation and purification of O and H antigens from Salmonella Enteritidis as diagnostic tool Annals of Microbiology 60 2010 565 571
16. K. Oda, H. Matsuda, T. Murakami, S. Katayama, T. Ohgitani, and M. Yoshikawa Adjuvant and hemolytic activities of 47 saponins derived from medicinal and food plants Biological Chemistry 381 2000 67 74 (Pubitemid 30102877)
17. M. Özipek, A.A. Donmez, I. Calis, R. Brun, P. Ruedi, and D. Tasdemir Leishmanicidal cycloartane-type triterpene glycosides from Astragalus oleifolius Phytochemistry 66 2005 1168 1173 (Pubitemid 40728313)
18. E. Polat, O. Caliskan-Alankus, A. Perrone, S. Piacente, and E. Bedir Cycloartane-type glycosides from Astragalus amblolepis Phytochemistry 70 2009 628 634
19. E. Polat, E. Bedir, A. Perrone, S. Piacente, and O. Alankus-Caliskan Triterpenoid saponins from Astragalus wiedemannianus Fischer Phytochemistry 71 2010 658 662
20. M.M. Radwan, N.A. El-Sebakhy, A.M. Asaad, S.M. Toaima, and D.G.I. Kingston Kahiricosides II-V, cycloartane glycosides from an Egyptian collection of Astragalus kahiricus Phytochemistry 65 2004 2909 2913 (Pubitemid 40292124)
21. G. Ragupathi, K.S. Yeung, P.C. Leunge, M. Lee, C.B.S. Lau, A. Vickersd, C. Hood, G. Dengb, N.K. Cheung, B. Cassileth, and P. Livingston Evaluation of widely consumed botanicals as immunological adjuvants Vaccine 26 2008 4860 4865
22. Z.I. Rajput, S. Hu, C. Xiao, and A.G. Arijo Review: adjuvant effects of saponins on animal immune responses Journal of Zhejiang University Science B 8 2007 153 161
23. J.L. Rios, and P.G. Waterman A review of the pharmacology and toxicology of Astragalus Phytotherapy Research 11 1997 411 418 (Pubitemid 27389299)
24. W.R. Santos, R.R. Bernardo, L.M. Pecanha, M. Palatnik, J.P. Parente, and C.B. Palatnik de Sousa Haemolytic activities of plant saponins and adjuvants. Effect of Periandra mediterranea saponin on the humoral response to the FML antigen of Leishmania donovani Vaccine 15 1997 1024 1029 (Pubitemid 27308581)
25. A. Sjölander, B. Van't Land, and K:l. Bengtsson Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-like immune responses Cellular Immunology 177 1997 69 76 (Pubitemid 27192324)
26. J. Sun, S. Hu, and X. Song Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice Vaccine 25 2007 1114 1120 (Pubitemid 44937445)
27. Y. Sun, H. Tong, M. Li, Y. Li, S. Guand, and J. Liu Immunological adjuvant effect of Japanese ginseng saponins (JGS) on specific antibody and cellular response to ovalbumin and its hemolytic activities Vaccine 26 2008 5911 5917
28. Y. Sun, M. Li, and J. Liu Hemolytic activities and adjuvant effect of Anemone raddeana saponins (ARS) on the immune responses to ovalbumin in mice International Immunopharmacology 8 2008 1095 1102
29. N. Tabanca, I. Calis, O. Alankus-Caliskan, and I.A. Khan Cycloartane triterpene glycosides from the roots of Astragalus gilvus Boiss Biochemical and Systematics Ecology 33 2005 1067 1070 (Pubitemid 40938587)
30. W. Tang, and G. Eisenbrand Chinese Drugs of Plant Origin 1992 Springer-Verlag Berlin pp. 191-197
31. M. Takechi, and Y. Tanaka Haemolytic time course differences between steroid and triterpenoid saponins Planta Medica 61 1995 76 77
32. Y.P. Wang, X.Y. Li, C.Q. Song, and Z.B. Hu Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage function in mice Acta Pharmacologica Sinica 23 2002 263 266
33. Y. Xie, H. Pan, H. Sun, and D. Li A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum Vaccine 26 2008 3937 3945
34. Y. Xie, Y.-P. Ye, H. Sun, and D. Li Contribution of the glycidic moieties to the hemolytic and adjuvant activity of platycodigenin-type saponins from the root of Platycodon grandiflorum Vaccine 26 2008 3452 3460
35. Z.G. Yang, H.X. Suna, and W.H. Fang Hemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice Vaccine 23 2005 5196 5203
36. E. Yeilada, E. Bedir, I. ali, Y. Takaishi, and Y. Ohmoto Effects of triterpene saponins from Astragalus species on in vitro cytokine release Journal of Ethnopharmacology 96 2005 71 77 (Pubitemid 39575033)
37. Z. Zheng, J. Dai, and M. Zhu Effect of injection of Astragalus membranaceus on the deformability of red blood cells Biorheology 32 1995 322