Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 1, 2012, Pages 209-214

  Ito, Daisuke ^a   Saito, Yu ^a   Matsumoto, Tomohiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; CELL MARKER; FUNGAL ENZYME; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MPS1 POMBE HOMOLOG KINASE; NDC80 COMPLEX; PROTEIN MAD1; PROTEIN MAD2; SCHIZOSACCHAROMYCES POMBE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL STRUCTURE; CENTROMERE; CHROMATIN; CHROMOSOME CONDENSATION; DISSOCIATION; ENZYME ANALYSIS; ENZYME LOCALIZATION; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; IMMUNOBLOTTING; M PHASE CELL CYCLE CHECKPOINT; METAPHASE; MICROTUBULE; MITOSIS; MITOSIS INHIBITION; MULTINUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; YEAST CELL;

BIOLOGICAL MARKERS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CENTROMERE; GREEN FLUORESCENT PROTEINS; KINETOCHORES; MITOSIS; MITOTIC SPINDLE APPARATUS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN KINASES; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

SCHIZOSACCHAROMYCETACEAE;

EID: 84855994508     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114647109     Document Type: Article

References (40)

1. Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8:379-393. (Pubitemid 46643240)
2. Li X, Nicklas RB (1995) Mitotic forces control a cell-cycle checkpoint. Nature 373:630-632.
3. Rieder CL, Cole RW, Khodjakov A, Sluder G (1995) The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J Cell Biol 130:941-948.
4. Hoyt MA, Totis L, Roberts BT (1991) S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66:507-517. (Pubitemid 121001387)
5. Li R, Murray AW (1991) Feedback control of mitosis in budding yeast. Cell 66:519-531. (Pubitemid 121001388)
6. Abrieu A, et al. (2001) Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint. Cell 106:83-93. (Pubitemid 32709960)
7. Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002) Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. EMBO J 21:1723-1732. (Pubitemid 34614628)
8. Weiss E, Winey M (1996) The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J Cell Biol 132:111-123. (Pubitemid 26035079)
9. Peters JM (2006) The anaphase promoting complex/cyclosome: A machine designed to destroy. Nat Rev Mol Cell Biol 7:644-656.
10. Fang G, Yu H, Kirschner MW (1998) The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev 12:1871-1883. (Pubitemid 28304339)
11. Hwang LH, et al. (1998) Budding yeast Cdc20: A target of the spindle checkpoint. Science 279:1041-1044. (Pubitemid 28113307)
12. Kim SH, Lin DP, Matsumoto S, Kitazono A, Matsumoto T (1998) Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint. Science 279:1045-1047. (Pubitemid 28113308)
13. Sczaniecka M, et al. (2008) The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C). J Biol Chem 283:23039-23047.
14. Chen RH, Waters JC, Salmon ED, Murray AW (1996) Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274:242-246. (Pubitemid 26353200)
15. Gillett ES, Espelin CW, Sorger PK (2004) Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J Cell Biol 164:535-546. (Pubitemid 38233315)
16. Howell BJ, et al. (2004) Spindle checkpoint protein dynamics at kinetochores in living cells. Curr Biol 14:953-964. (Pubitemid 38722609)
17. Sudakin V, Chan GK, Yen TJ (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol 154:925-936. (Pubitemid 34286173)
18. Millband DN, Hardwick KG (2002) Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner. Mol Cell Biol 22:2728-2742. (Pubitemid 34262993)
19. Hardwick KG, Weiss E, Luca FC, Winey M, Murray AW (1996) Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 273:953-956. (Pubitemid 26275171)
20. He X, Jones MH, Winey M, Sazer S (1998) Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. J Cell Sci 111:1635-1647. (Pubitemid 28330551)
21. Martin-Lluesma S, Stucke VM, Nigg EA (2002) Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 297:2267-2270.
22. Liu ST, et al. (2003) Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores. Mol Biol Cell 14:1638-1651.
23. Santaguida S, Tighe A, D'Alise AM, Taylor SS, Musacchio A (2010) Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol 190:73-87.
24. Maciejowski J, et al. (2010) Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol 190:89-100.
25. Hewitt L, et al. (2010) Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol 190:25-34.
26. Tange Y, Niwa O (2008) Schizosaccharomyces pombe Bub3 is dispensable for mitotic arrest following perturbed spindle formation. Genetics 179:785-792.
27. Vanoosthuyse V, Meadows JC, van der Sar SJ, Millar JB, Hardwick KG (2009) Bub3p facilitates spindle checkpoint silencing in fission yeast. Mol Biol Cell 20:5096-5105.
28. Windecker H, Langegger M, Heinrich S, Hauf S (2009) Bub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshin. EMBO Rep 10:1022-1028.
29. Lauzé E, et al. (1995) Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. EMBO J 14:1655-1663.
30. Fisk HA, Winey M (2001) The mouse Mps1p-like kinase regulates centrosome duplication. Cell 106:95-104. (Pubitemid 32709961)
31. Yamamoto A, Hiraoka Y (2003) Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast. EMBO J 22:2284-2296. (Pubitemid 36565551)
32. Pinsky BA, Nelson CR, Biggins S (2009) Protein phosphatase 1 regulates exit from the spindle checkpoint in budding yeast. Curr Biol 19:1182-1187.
33. Hiraoka Y, Toda T, Yanagida M (1984) The NDA3 gene of fission yeast encodes beta-tubulin: A cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis. Cell 39:349-358. (Pubitemid 15191218)
34. Cheeseman IM, Chappie JS, Wilson-Kubalek EM, Desai A (2006) The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127:983-997. (Pubitemid 44792248)
35. Jelluma N, Dansen TB, Sliedrecht T, Kwiatkowski NP, Kops GJ (2010) Release of Mps1 from kinetochores is crucial for timely anaphase onset. J Cell Biol 191:281-290.
36. Kemmler S, et al. (2009) Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling. EMBO J 28:1099-1110.
37. Rischitor PE, May KM, Hardwick KG (2007) Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes. PLoS ONE 2:e1342.
38. Chi YH, et al. (2008) Requirements for protein phosphorylation and the kinase activity of polo-like kinase 1 (Plk1) for the kinetochore function of mitotic arrest deficiency protein 1 (Mad1). J Biol Chem 283:35834-35844.
39. Saurin AT, van der Waal MS, Medema RH, Lens SM, Kops GJ (2011) Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun 2:316.
40. Moreno S, Klar A, Nurse P (1991) Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 194:795-823.