Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 34, 2004, Pages 12508-12513

  Kim, Jong Myoung ^a   Altenbach, Christian ^b   Kono, Masahiro ^c,d   Oprian, Daniel D ^c   Hubbell, Wayne L ^b   Khorana, H Gobind ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b JULES STEIN EYE INSTITUTE   (United States)

^c BRANDEIS UNIVERSITY   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

EPR; G protein coupled receptor; Signal transduction; Site directed spin labeling

Indexed keywords

ALANINE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GLUTAMINE; GLYCINE; LYSINE; METHIONINE; OPSIN; RHODOPSIN; SCHIFF BASE; TYROSINE;

ARTICLE; DARKNESS; ELECTRON SPIN RESONANCE; HUMAN; MOLECULAR INTERACTION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTON TRANSPORT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SPIN LABELING; STRUCTURE ANALYSIS;

ANIMALS; ELECTRON SPIN RESONANCE SPECTROSCOPY; LIGHT; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RHODOPSIN; SPIN LABELS; TRANSDUCIN;

EID: 4344674667     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0404519101     Document Type: Article

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