The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis

Pharmacological Research

Volumn 65, Issue 2, 2012, Pages 221-230

  Galbiati, Mariarita ^a,b   Onesto, Elisa ^a,b   Zito, Arianna ^a,b   Crippa, Valeria ^a,b   Rusmini, Paola ^a,b   Mariotti, Raffaella ^c   Bentivoglio, Marina ^c   Bendotti, Caterina ^d   Poletti, Angelo ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Amyotrophic lateral sclerosis; Anabolic steroids; Androgens; Motor neuron disease; Muscle; Nandrolone; TGFbeta1

Indexed keywords

ANABOLIC AGENT; ANDROGEN; MESSENGER RNA; MYOD PROTEIN; MYOGENIN; NANDROLONE; TRANSFORMING GROWTH FACTOR BETA1;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROGIN 1 GENE; CALPAIN1 GENE; CONTROLLED STUDY; DNA DETERMINATION; DNA MODIFICATION; DRUG EFFECT; GASTROCNEMIUS MUSCLE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; IN VIVO STUDY; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE DENERVATION; MYOGENIN GENE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SUPEROXIDE DISMUTASE 1 GENE; TRANSFORMING GROWTH FACTOR BETA1 GENE; UPREGULATION; WESTERN BLOTTING;

AMYOTROPHIC LATERAL SCLEROSIS; ANABOLIC AGENTS; ANDROGENS; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MUTATION; MYOBLASTS; MYOD PROTEIN; MYOGENIN; NANDROLONE; SKP CULLIN F-BOX PROTEIN LIGASES; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84855989313     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.12.001     Document Type: Article

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