Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1- 13C diethyl succinate

Journal of the American Chemical Society

Volumn 134, Issue 2, 2012, Pages 934-943

  Zacharias, Niki M ^a,b   Chan, Henry R ^a   Sailasuta, Napapon ^a   Ross, Brian D ^a   Bhattacharya, Pratip ^a  

^a HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

^b California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3-NITROPROPIONATE; ASPARTATES; BOLTZMANN; CHEMICAL SPECIFICITY; DIETHYL SUCCINATE; DISEASE STATE; FLUORO 2 DEOXY D GLUCOSE; FUMARATES; GLUCOSE UPTAKE; HIGH SIGNAL-TO-NOISE RATIO; HYPERPOLARIZATION; HYPERPOLARIZED; IN-VIVO; IN-VIVO IMAGING; METABOLIC ENERGY; METABOLIC IMAGING; MOLECULAR IMAGING; MRI AND MRS; SIGNAL ENHANCEMENT; SUCCINATE DEHYDROGENASE; TCA CYCLE; TIME-SCALES; TRICARBOXYLIC ACID CYCLE;

FADING (RADIO); GLUCOSE; MAGNETIC RESONANCE SPECTROSCOPY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; POLARIZATION; POSITRON EMISSION TOMOGRAPHY; SIGNAL TO NOISE RATIO; VISUALIZATION;

MAGNETIC RESONANCE IMAGING;

3 NITROPROPIONIC ACID; ASPARTIC ACID; FUMARIC ACID; HYDROGEN; MALIC ACID; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; SUCCINIC ACID DERIVATIVE; SUCCINIC ACID DIETHYL ESTER; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL METABOLISM; CONTROLLED STUDY; HYPERPOLARIZATION; IN VIVO STUDY; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PROTON NUCLEAR MAGNETIC RESONANCE; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; SPECTROSCOPY; SYNTHESIS;

ANIMALS; CARBON ISOTOPES; CITRIC ACID CYCLE; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED BALB C; SPECTRUM ANALYSIS; SUCCINATES; TISSUE DISTRIBUTION;

EID: 84855947491     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2040865     Document Type: Article

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