Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor

Oncogene

Volumn 31, Issue 3, 2012, Pages 366-375

  Rego, M A ^a   Harney, J A ^a   Mauro, M ^a   Shen, M ^a   Howlett, N G ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

deubiquitination; DNA repair; Fanconi anemia; genome stability; ubiquitination

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA; FANCONI ANEMIA GROUP D2 PROTEIN; FANCONI ANEMIA GROUP I PROTEIN; FANCONI ANEMIA PROTEIN; GAMM HISTONE H2AX; HISTONE H2AX; MITOMYCIN C; PROTEIN P53; PROTEIN UBE2T; PROTEIN USP1; PROTEINASE; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UBIQUITINATION;

BRCA1 PROTEIN; BRCA2 PROTEIN; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; HISTONES; HUMANS; MITOMYCIN; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84855925244     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.237     Document Type: Article

References (54)

1. Abbas T, Dutta A. (2009). p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 9: 400-414.
2. Abbas T, Sivaprasad U, Terai K, Amador V, PaganoM, Dutta A. (2008). PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev 22: 2496-2506.
3. Abukhdeir AM, Park BH. (2008). P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med 10: e19.
4. Adamo A, Collis SJ, Adelman CA, Silva N, Horejsi Z, Ward JD et al. (2010). Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol Cell 39: 25-35.
5. Alpi A, Langevin F, Mosedale G, Machida YJ, Dutta A, Patel KJ. (2007). UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol Cell Biol 27: 8421-8430.
6. Andreassen PR, D'Andrea AD, Taniguchi T. (2004). ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev 18: 1958-1963. (Pubitemid 39071576)
7. Arlt MF, Xu B, Durkin SG, Casper AM, Kastan MB, Glover TW. (2004). BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol Cell Biol 24: 6701-6709. (Pubitemid 38944349)
8. Auerbach AD. (1993). Fanconi anemia diagnosis and the diepoxybutane (DEB) test. Exp Hematol 21: 731-733. (Pubitemid 24215323)
9. Avkin S, Sevilya Z, Toube L, Geacintov N, Chaney SG, Oren M et al. (2006). p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Mol Cell 22: 407-413.
10. Bendjennat M, Boulaire J, Jascur T, Brickner H, Barbier V, Sarasin A et al. (2003). UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Cell 114: 599-610. (Pubitemid 37159256)
11. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP et al. (1998). Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282: 1497-1501. (Pubitemid 28538613)
12. Chan KL, Palmai-Pallag T, Ying S, Hickson ID. (2009). Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol 11: 753-760.
13. Chen U, Chen S, Saha P, Dutta A. (1996). p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci USA 93: 11597-11602.
14. Cohn MA, Kowal P, Yang K, Haas W, Huang TT, Gygi SP et al. (2007). A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell 28: 786-797. (Pubitemid 350217060)
15. Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ. (2007). HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol 9: 391-401. (Pubitemid 46511072)
16. Di Leonardo A, Linke SP, Clarkin K, Wahl GM. (1994). DNA damage triggers a prolonged p53-dependent G1 arrest and longterm induction of Cip1 in normal human fibroblasts. Genes Dev 8: 2540-2551. (Pubitemid 24347245)
17. el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, Jackman J et al. (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174. (Pubitemid 24108052)
18. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825. (Pubitemid 23346378)
19. Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn MS, Timmers C, Hejna J et al. (2001). Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell 7: 249-262. (Pubitemid 32206493)
20. Harney JA, Shimamura A, Howlett NG. (2008). Fanconi anemia: a multi-age cancer susceptibility syndrome. Pediatric Health 2: 175-187. (Pubitemid 351824564)
21. Hoskins EE, Gunawardena RW, Habash KB, Wise-Draper TM, Jansen M, Knudsen ES et al. (2008). Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. Oncogene 27: 4798-4808.
22. Howlett NG, Harney JA, Rego MA, Kolling FW, Glover TW. (2009). Functional interaction between the Fanconi anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem 284: 28935-28942.
23. Howlett NG, Taniguchi T, Durkin SG, D'Andrea AD, Glover TW. (2005). The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet 14: 693-701. (Pubitemid 40309594)
24. Howlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, De Die-Smulders C et al. (2002). Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297: 606-609. (Pubitemid 34815345)
25. Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W et al. (2006). Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol 8: 339-347.
26. Kee Y, D'Andrea AD. (2010). Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev 24: 1680-1694.
27. Kim Y, Lach FP, Desetty R, Hanenberg H, Auerbach AD, Smogorzewska A. (2011). Mutations of the SLX4 gene in Fanconi anemia. Nat Genet 43: 142-146.
28. Kim Y, Starostina NG, Kipreos ET. (2008). The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev 22: 2507-2519.
29. Kratz K, Schopf B, Kaden S, Sendoel A, Eberhard R, Lademann C et al. (2010). Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Cell 142: 77-88.
30. Liu T, Ghosal G, Yuan J, Chen J, Huang J. (2010). FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 329: 693-696.
31. Machida YJ, Machida Y, Chen Y, Gurtan AM, Kupfer GM, D'Andrea AD et al. (2006). UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell 23: 589-596. (Pubitemid 44205488)
32. MacKay C, Declais AC, Lundin C, Agostinho A, Deans AJ, MacArtney TJ et al. (2010). Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell 142: 65-76.
33. Mathew CG. (2006). Fanconi anaemia genes and susceptibility to cancer. Oncogene 25: 5875-5884. (Pubitemid 44453443)
34. Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ et al. (2003). A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet 35: 165-170. (Pubitemid 37187635)
35. Moldovan GL, D'Andrea AD. (2009). How the Fanconi anemia pathway guards the genome. Annu Rev Genet 43: 223-249.
36. Naim V, Rosselli F. (2009). The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat Cell Biol 11: 761-768.
37. Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D'Andrea AD et al. (2005). Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci USA 102: 1110-1115. (Pubitemid 40170734)
38. Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD et al. (2005). The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell 17: 331-339. (Pubitemid 40193305)
39. Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M, Patel KJ. (2010). Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway. Science 329: 219-223.
40. Podust VN, Podust LM, Goubin F, Ducommun B, Hubscher U. (1995). Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21. Biochemistry 34: 8869-8875.
41. Prives C, Gottifredi V. (2008). The p21 and PCNA partnership: a new twist for an old plot. Cell Cycle 7: 3840-3846.
42. Rego MA, Kolling FW, Howlett NG. (2009). The Fanconi anemia protein interaction network: casting a wide net. Mutat Res 668: 27-41.
43. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. (1998). DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273: 5858-5868. (Pubitemid 28124064)
44. Sims AE, Spiteri E, Sims III RJ, Arita AG, Lach FP, Landers T et al. (2007). FANCI is a second monoubiquitinated member of the Fanconi anemia pathway. Nat Struct Mol Biol 14: 564-567. (Pubitemid 46871814)
45. Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME et al. (2010). A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell 39: 36-47.
46. Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald III ER, Hurov KE, Luo J et al. (2007). Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 129: 289-301. (Pubitemid 46584733)
47. Stoepker C, Hain K, Schuster B, Hilhorst-Hofstee Y, Rooimans MA, Steltenpool J et al. (2011). SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet 43: 138-141.
48. Taniguchi T, Garcia-Higuera I, Andreassen PR, Gregory RC, Grompe M, D'Andrea AD. (2002). S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 100: 2414-2420.
49. Vaz F, Hanenberg H, Schuster B, Barker K, Wiek C, Erven V et al. (2010). Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet 42: 406-409.
50. Waldman T, Kinzler KW, Vogelstein B. (1995). p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 55: 5187-5190.
51. Wang X, Andreassen PR, D'Andrea AD. (2004). Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol 24: 5850-5862. (Pubitemid 38787970)
52. Wang X, Kennedy RD, Ray K, Stuckert P, Ellenberger T, D'Andrea AD. (2007). Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol Cell Biol 27: 3098-3108. (Pubitemid 46581321)
53. Yamamoto K, Hirano S, Ishiai M, Morishima K, Kitao H, Namikoshi K et al. (2005). Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Mol Cell Biol 25: 34-43. (Pubitemid 40039797)
54. Yamazoe M, Sonoda E, Hochegger H, Takeda S. (2004). Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40. DNA Repair (Amst) 3: 1175-1185. (Pubitemid 38997961)