Structural and biophysical insights into the ligand-free pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant

Biochemistry

Volumn 51, Issue 2, 2012, Pages 665-676

  Doerdelmann, Thomas ^a   Kojetin, Douglas J ^a,b   Baird Titus, Jamie M ^c   Solt, Laura A ^b   Burris, Thomas P ^b   Rance, Mark ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c College of Mount St Joseph ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL OBSERVATION; DNA BINDING AFFINITY; DYNAMIC ENVIRONMENTS; EMBRYONIC TISSUE; FUNCTIONAL UNITS; HOMEODOMAIN; ISOFORMS; LIGAND-FREE; MUTATION RESULTS; NUCLEAR MAGNETIC RESONANCE TECHNIQUES; SOLUTION STRUCTURES; TRANSACTIVATION ACTIVITY;

BINDING ENERGY; TISSUE; TRANSCRIPTION FACTORS;

DNA SEQUENCES;

HOMEODOMAIN INTERACTING PROTEIN KINASE 2; LIGAND; TRANSCRIPTION FACTOR PITX2;

AMINO ACID SEQUENCE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CORNEA; CORNEA DISEASE; DNA SEQUENCE; HUMAN; HUMAN CELL; MUTANT; MUTATION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STRUCTURE; TERATOMA;

AMINO ACID SEQUENCE; BIOPHYSICAL PROCESSES; CONJUNCTIVAL DISEASES; CORNEAL DISEASES; DERMOID CYST; DNA; GENES, REPORTER; HISTIDINE; HOMEODOMAIN PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; LUCIFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SOLUTIONS; THERMODYNAMICS; TRANSCRIPTION FACTORS;

EID: 84855917443     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201639x     Document Type: Article

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