Immunization with A91 peptide or copolymer-1 reduces the production of nitric oxide and inducible nitric oxide synthase gene expression after spinal cord injury

Journal of Neuroscience Research

Volumn 90, Issue 3, 2012, Pages 656-663

  García, Elisa ^a,b   Silva García, Raúl ^c   Mestre, Humberto ^a   Flores, Nayeli ^b   Martiñón, Susana ^b   Calderón Aranda, Emma S ^d   Ibarra, Antonio ^a,b  

^a UNIVERSIDAD ANÁHUAC   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c HOSPITAL DE PEDIATRÍA   (Mexico)

^d DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

A91; Cop 1; Neural antigens; Paraplegia; Protective autoimmunity

Indexed keywords

A91 PEPTIDE; GLATIRAMER; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; COCULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE EXPRESSION; GLIA CELL; IMMUNE RESPONSE; MOUSE; NEUROPROTECTION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; T LYMPHOCYTE; VACCINATION;

ANIMALS; CELL PROLIFERATION; IMMUNIZATION; MICE; MICE, INBRED BALB C; MYELIN BASIC PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDES; RATS; RATS, INBRED F344; SPINAL CORD; SPINAL CORD INJURIES; T-LYMPHOCYTES;

EID: 84855902496     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22771     Document Type: Article

References (40)

1. Arnon R, Sela M. 2003. Immunomodulation by the copolymer glatiramer acetate. J Mol Recogn 16: 412-421.
2. Bao F, Liu D. 2003. Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3. Neuroscience 116: 59-70.
3. Basso DM, Beattie MS, Bresnahan JC. 1996. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139: 244-256.
4. Bhat NR, Zhang P, Lee JC, Hogan EL. 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18: 1633-1641.
5. Bruun C, Heding PE, Ronn SG, Frobose H, Rhodes CJ, Mandrup-Poulsen T, Billestrup N. 2009. Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells. Mol Cell Endocrinol 311: 32-38.
6. Butovsky O, Talpalar AE, Ben-Yaakov K, Schwartz M. 2005. Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective. Mol Cell Neurosci 29: 381-393.
7. Calderon-Aranda ES, Selisko B, York EJ, Gurrola GB, Stewart JM, Possani LD. 1999. Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides. Eur J Biochem 264: 746-755.
8. Chesrown SE, Monnier J, Visner G, Nick HS. 1994. Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages. Biochem Biophys Res Commun 200: 126-134.
9. Crespo A, Filla MB, Murphy WJ. 2002. Low responsiveness to IFN-gamma, after pretreatment of mouse macrophages with lipopolysaccharides, develops via diverse regulatory pathways. Eur J Immunol 32: 710-719.
10. Dawson VL, Dawson TM. 1998. Nitric oxide in neurodegeneration. Prog Brain Res 118: 215-229.
11. Gaur A, Boehme SA, Chalmers D, Crowe PD, Pahuja A, Ling N, Brocke S, Steinman L, Conlon PJ. 1997. Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J Neuroimmunol 74: 149-158.
12. Gilad GM, Shanker G, Dahl D, Gilad VH. 1990. Dibutyryl cyclic AMP-induced changes in neuron-astroglia interactions and fibronectin immunocytochemistry in dissociated rat cerebellar cultures. Brain Res 508: 215-224.
13. Gordon S. 2003. Alternative activation of macrophages. Nat Rev Immunol 3: 23-35.
14. 15N]nitrate in biological fluids. Anal Biochem 126: 131-138.
15. Hauben E, Agranov E, Gothilf A, Nevo U, Cohen A, Smirnov I, Steinman L, Schwartz M. 2001. Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease. J Clin Invest 108: 591-599.
16. Ibarra A, Avendaño H, Cruz Y. 2007. Copolymer-1 (Cop-1) improves neurological recovery after middle cerebral artery occlusion in rats. Neurosci Lett 425: 110-113.
17. Ibarra A, Garcia E, Flores N, Martinon S, Reyes R, Campos MG, Maciel M, Mestre H. 2010. Immunization with neural-derived antigens inhibits lipid peroxidation after spinal cord injury. Neurosci Lett 476: 62-65.
18. Kakita H, Aoyama M, Hussein MH, Kato S, Suzuki S, Ito T, Togari H, Asai K. 2009. Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes. Toxicol Appl Pharmacol 238: 56-63.
19. Karlsen AE, Ronn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N. 2001. Suppressor of cytokine signaling 3 (SOCS-3) protects beta-cells against interleukin-1beta- and interferon-gamma-mediated toxicity. Proc Natl Acad Sci U S A 98: 12191-12196.
20. + regulatory T cells. Ann N Y Acad Sci 1051: 701-708.
21. Kipnis J, Yoles E, Schori H, Hauben E, Shaked I, Schwartz M. 2001. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J Neurosci 21: 4564-4571.
22. Kipnis J, Mizrahi T, Yoles E, Ben-Nun A, Schwartz M. 2002. Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity. J Neuroimmunol 130: 78-85.
23. Kwak EK, Kim JW, Kang KS, Lee YH, Hua QH, Park TI, Park JY, Sohn YK. 2005. The role of inducible nitric oxide synthase following spinal cord injury in rat. J Korean Med Sci 20: 663-669.
24. Liu D, Ling X, Wen J, Liu J. 2000. The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 75: 2144-2154.
25. Louis CA, Mody V, Henry WLJr, Reichner JS, Albina JE. 1999. Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages. Am J Physiol 27: R237-R232.
26. Martiñon S, Garcia E, Flores N, Gonzalez I, Ortega T, Buenrostro M, Reyes R, Fernandez-Presas AM, Guizar-Sahagun G, Correa D, Ibarra A. 2007. Vaccination with a neural-derived peptide plus administration of glutathione improves the performance of paraplegic rats. Eur J Neurosci 26: 403-412.
27. McNamee EN, Ryan KM, Griffin EW, Gonzalez-Reyes RE, Ryan KJ, Harkin A, Connor TJ. 2010. Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration. Brain Behav Immun 24: 660-671.
28. Meng X, Kawahara K, Matsushita K, Nawa Y, Shrestha B, Kikuchi K, Sameshima H, Hashiguchi T, Maruyama I. 2009. Attenuation of LPS-induced iNOS expression by 1, 5-anhydro-d-fructose. Biochem Biophys Res Commun 387: 42-46.
29. + mycobacterial lipoarabinomannan-induced NO by IL-4 is due to decreased IRF-1 expression. Tuberculosis 89: 294-303.
30. Nakahara S, Yone K, Setoguchi T, Yamaura I, Arishima Y, Yoshino S, Komiya S. 2002. Changes in nitric oxide and expression of nitric oxide synthase in spinal cord after acute traumatic injury in rats. J Neurotrauma 19: 1467-1474.
31. Pannu R, Singh I. 2006. Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms. Neurochem Int 49: 170-182.
32. Sass JB, Haselow DT, Silbergeld EK. 2001. Methylmercury-induced decrement in neuronal migration may involve cytokine-dependent mechanisms: a novel method to assess neuronal movement in vitro. Toxicol Sci 63: 74-81.
33. Shaked I, Tchoresh D, Gersner R, Meiri G, Mordechai S, Xiao X, Hart RP, Schwartz M. 2005. Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators. J Neurochem 92: 997-1009.
34. Shechter R, London A, Varol C, Raposo C, Cusimano M, Yovel G, Rolls A, Mack M, Pluchino S, Martino G, Jung S, Schwartz M. 2009. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PloS Med 6: e1000113.
35. Teitelbaum D, Webb C, Bree M, Meshorer A, Arnon R, Sela M. 1974. Suppression of experimental allergic encephalomyelitis in rhesus monkeys by a synthetic basic copolymer. Clin Immunol Immunopathol 3: 256.
36. van Strien ME, Mercier D, Drukarch B, Breve JJ, Poole S, Binnekade R, Bo JG, Blits B, Verhaagen J, van Dam AM. 2010. Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages. Gene Ther 17: 662-671.
37. Xiong Y, Hall ED. 2009. Pharmacological evidence for a role of peroxynitrite in the pathophysiology of spinal cord injury. Exp Neurol 216: 105-114.
38. Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M. 2001. Protective autoimmunity is a physiological response to CNS trauma. J Neurosci 21: 3740-3748.
39. Zhuang P, Ji H, Zhang YH, Min ZL, Ni QG, You R. 2009. ZJM-289, a novel nitric oxide donor, alleviates the cerebral ischemic-reperfusion injury in rats. Clin Exp Pharmacol Physiol DOI: 10.1111/j.1440-1681.2009.05353.x.
40. Ziv Y, Avidan H, Pluchino S, Martino G, Schwartz M. 2006. Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc Natl Acad Sci U S A 103: 13174-13179.