메뉴 건너뛰기




Volumn 26, Issue 2, 2007, Pages 403-412

Vaccination with a neural-derived peptide plus administration of glutathione improves the performance of paraplegic rats

Author keywords

Compression; Glutathione mono ethyl ester; Neuroprotection; Protective autoimmunity; Reimmunization; Spinal cord injury

Indexed keywords

A91 PEPTIDE; GLUTATHIONE ETHYL ESTER; LIPID; PEPTIDE DERIVATIVE; PHOSPHATE BUFFERED SALINE; UNCLASSIFIED DRUG;

EID: 34447625768     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2007.05650.x     Document Type: Article
Times cited : (24)

References (50)
  • 1
    • 0029961719 scopus 로고    scopus 로고
    • Die and let live: Eliminating dangerous lymphocytes
    • Abbas, A.K. (1996) Die and let live: eliminating dangerous lymphocytes. Cell, 84, 655 657.
    • (1996) Cell , vol.84 , pp. 655-657
    • Abbas, A.K.1
  • 3
    • 10944246635 scopus 로고    scopus 로고
    • Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: Effect of CD4+CD25+ T cells
    • Avidan, H., Kipnis, J., Butovsky, O., Caspi, R.R. Schwartz, M. (2004) Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells. Eur. J. Immunol., 34, 3434 3445.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 3434-3445
    • Avidan, H.1    Kipnis, J.2    Butovsky, O.3    Caspi, R.R.4    Schwartz, M.5
  • 4
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso, D.M., Beattie, M.S. Bresnahan, J.C. (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma, 12, 1 21.
    • (1995) J. Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 5
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand 4
    • Bielekova, B., Goodwin, B., Richert, N., Cortese, I., Kondo, T., Afshar, G., Gran, B., Eaton, J., Antel, J., Frank, J.A., McFarland, H.F. Martin, R. (2000) Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand 4. Nat. Med., 6, 1167 1175.
    • (2000) Nat. Med. , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10    McFarland, H.F.11    Martin, R.12
  • 6
    • 11144302532 scopus 로고    scopus 로고
    • A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice
    • Buchwald, U.K., Lees, A., Steinitz, M. Pirofski, L.A. (2005) A peptide mimotope of type 8 pneumococcal capsular polysaccharide induces a protective immune response in mice. Infect. Immun., 73, 325 333.
    • (2005) Infect. Immun. , vol.73 , pp. 325-333
    • Buchwald, U.K.1    Lees, A.2    Steinitz, M.3    Pirofski, L.A.4
  • 7
    • 32944462606 scopus 로고    scopus 로고
    • Systematic review of the diagnosis and management of malignant extradural spine cord compression: The Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group
    • Chamberlain, M.C., Sloan, A. Vrionis, F. (2005) Systematic review of the diagnosis and management of malignant extradural spine cord compression: The Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group. J. Clin. Oncol., 23, 7750 7751.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7750-7751
    • Chamberlain, M.C.1    Sloan, A.2    Vrionis, F.3
  • 9
    • 1542358946 scopus 로고    scopus 로고
    • Basic advances and new avenues in therapy of spinal cord injury
    • Dobkin, B.H. Havton, L.A. (2004) Basic advances and new avenues in therapy of spinal cord injury. Annu. Rev. Med., 55, 255 282.
    • (2004) Annu. Rev. Med. , vol.55 , pp. 255-282
    • Dobkin, B.H.1    Havton, L.A.2
  • 14
    • 0030973661 scopus 로고    scopus 로고
    • Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms
    • Gaur, A., Boehme, S.A., Chalmers, D., Crowe, P.D., Pahuja, A., Ling, N., Brocke, S., Steinman, L. Conlon, P.J. (1997) Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J. Neuroimmunol., 74, 149 158.
    • (1997) J. Neuroimmunol. , vol.74 , pp. 149-158
    • Gaur, A.1    Boehme, S.A.2    Chalmers, D.3    Crowe, P.D.4    Pahuja, A.5    Ling, N.6    Brocke, S.7    Steinman, L.8    Conlon, P.J.9
  • 16
    • 0037047154 scopus 로고    scopus 로고
    • Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma
    • Gorio, A., Gokmen, N., Erbayraktar, S., Yilmaz, O., Madaschi, L., Cichetti, C., Di Giulio, A.M., Vardar, E., Cerami, A. Brines, M. (2002) Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. PNAS, 99, 9450 9455.
    • (2002) PNAS , vol.99 , pp. 9450-9455
    • Gorio, A.1    Gokmen, N.2    Erbayraktar, S.3    Yilmaz, O.4    Madaschi, L.5    Cichetti, C.6    Di Giulio, A.M.7    Vardar, E.8    Cerami, A.9    Brines, M.10
  • 17
    • 10044242356 scopus 로고    scopus 로고
    • Glutathione monoethyl ester improves functional recovery, enhances neuron survival, and stabilizes spinal cord blood flow after spinal cord injury in rats
    • Guizar-Sahagun, G., Ibarra, A., Espitia, A., Martinez, A., Madrazo, I. Franco-Bourland, R.E. (2005) Glutathione monoethyl ester improves functional recovery, enhances neuron survival, and stabilizes spinal cord blood flow after spinal cord injury in rats. Neuroscience, 130, 639 649.
    • (2005) Neuroscience , vol.130 , pp. 639-649
    • Guizar-Sahagun, G.1    Ibarra, A.2    Espitia, A.3    Martinez, A.4    Madrazo, I.5    Franco-Bourland, R.E.6
  • 18
    • 0034893791 scopus 로고    scopus 로고
    • Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease
    • Hauben, E., Agranov, E., Gothilf, A., Nevo, U., Cohen, A., Smirnov, I., Steinman, L. Schwartz, M. (2001a) Posttraumatic therapeutic vaccination with modified myelin self-antigen prevents complete paralysis while avoiding autoimmune disease. J. Clin. Invest, 108, 591 599.
    • (2001) J. Clin. Invest , vol.108 , pp. 591-599
    • Hauben, E.1    Agranov, E.2    Gothilf, A.3    Nevo, U.4    Cohen, A.5    Smirnov, I.6    Steinman, L.7    Schwartz, M.8
  • 20
    • 0141535147 scopus 로고    scopus 로고
    • Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury
    • Hauben, E., Gothilf, A., Cohen, A., Butovsky, O., Nevo, U., Smirnov, I., Yoles, E., Akselrod, S. Schwartz, M. (2003) Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury. J. Neurosci., 23, 8808 8819.
    • (2003) J. Neurosci. , vol.23 , pp. 8808-8819
    • Hauben, E.1    Gothilf, A.2    Cohen, A.3    Butovsky, O.4    Nevo, U.5    Smirnov, I.6    Yoles, E.7    Akselrod, S.8    Schwartz, M.9
  • 21
    • 0035910038 scopus 로고    scopus 로고
    • Vaccination with a Nogo-A-derived peptide after incomplete spinal-cord injury promotes recovery via a T-cell-mediated neuroprotective response: Comparison with other myelin antigens
    • Hauben, E., Ibarra, A., Mizrahi, T., Barouch, R., Agranov, E. Schwartz, M. (2001b) Vaccination with a Nogo-A-derived peptide after incomplete spinal-cord injury promotes recovery via a T-cell-mediated neuroprotective response: comparison with other myelin antigens. Proc. Natl Acad. Sci. USA, 98, 15173 15178.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 15173-15178
    • Hauben, E.1    Ibarra, A.2    Mizrahi, T.3    Barouch, R.4    Agranov, E.5    Schwartz, M.6
  • 24
    • 0038722051 scopus 로고    scopus 로고
    • Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury
    • Ibarra, A., Correa, D., Willms, K., Merchant, M.T., Guizar-Sahagun, G., Grijalva, I. Madrazo, I. (2003) Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury. Brain Res., 979, 165 178.
    • (2003) Brain Res. , vol.979 , pp. 165-178
    • Ibarra, A.1    Correa, D.2    Willms, K.3    Merchant, M.T.4    Guizar-Sahagun, G.5    Grijalva, I.6    Madrazo, I.7
  • 25
    • 3042662126 scopus 로고    scopus 로고
    • The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats
    • Ibarra, A., Hauben, E., Butovsky, O. Schwartz, M. (2004) The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats. Eur. J. Neurosci., 19, 2984 2990.
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 2984-2990
    • Ibarra, A.1    Hauben, E.2    Butovsky, O.3    Schwartz, M.4
  • 27
    • 1942521774 scopus 로고    scopus 로고
    • Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats
    • Jones, T.B., Ankeny, D.P., Guan, Z., McGaughy, V., Fisher, L.C., Basso, D.M. Popovich, P.G. (2004) Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats. J. Neurosci., 24, 3752 3761.
    • (2004) J. Neurosci. , vol.24 , pp. 3752-3761
    • Jones, T.B.1    Ankeny, D.P.2    Guan, Z.3    McGaughy, V.4    Fisher, L.C.5    Basso, D.M.6    Popovich, P.G.7
  • 28
    • 0020807360 scopus 로고
    • Acute spinal cord injury in the rat: Comparison of three experimental techniques
    • Khan, M. Griebel, R. (1983) Acute spinal cord injury in the rat: comparison of three experimental techniques. Can. J. Neurol. Sci., 10, 161 165.
    • (1983) Can. J. Neurol. Sci. , vol.10 , pp. 161-165
    • Khan, M.1    Griebel, R.2
  • 29
    • 0022255258 scopus 로고
    • Hemorrhagic changes in experimental spinal cord injury models
    • Khan, M., Griebel, R., Rozdilsky, B. Politis, M. (1985) Hemorrhagic changes in experimental spinal cord injury models. Can. J. Neurol. Sci., 12, 259 262.
    • (1985) Can. J. Neurol. Sci. , vol.12 , pp. 259-262
    • Khan, M.1    Griebel, R.2    Rozdilsky, B.3    Politis, M.4
  • 30
    • 0000320310 scopus 로고    scopus 로고
    • Glutathione: Systemic protectant against oxidative and free radical damage
    • Kidd, P.M. (1997) Glutathione: systemic protectant against oxidative and free radical damage. Altern. Med. Rev., 2, 155 176.
    • (1997) Altern. Med. Rev. , vol.2 , pp. 155-176
    • Kidd, P.M.1
  • 31
    • 0036708987 scopus 로고    scopus 로고
    • Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity
    • Kipnis, J., Mizrahi, T., Yoles, E., Ben-Nun, A. Schwartz, M. (2002) Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity. J. Neuroimmunol., 130, 78 85.
    • (2002) J. Neuroimmunol. , vol.130 , pp. 78-85
    • Kipnis, J.1    Mizrahi, T.2    Yoles, E.3    Ben-Nun, A.4    Schwartz, M.5
  • 32
    • 0035400122 scopus 로고    scopus 로고
    • Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response
    • Kipnis, J., Yoles, E., Schori, H., Hauben, E., Shaked, I. Schwartz, M. (2001) Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J. Neurosci., 21, 4564 4571.
    • (2001) J. Neurosci. , vol.21 , pp. 4564-4571
    • Kipnis, J.1    Yoles, E.2    Schori, H.3    Hauben, E.4    Shaked, I.5    Schwartz, M.6
  • 34
    • 0028363624 scopus 로고
    • T cell anergy
    • Lasalle, J.M. (1994) T cell anergy. FASEB J., 8, 601 608.
    • (1994) FASEB J. , vol.8 , pp. 601-608
    • Lasalle, J.M.1
  • 35
    • 0034931582 scopus 로고    scopus 로고
    • The contribution of T-cell anergy to peripheral T-cell tolerance
    • Lechler, R., Chai, J.G., Marelli-Berg, F. Lombardi, G. (2001) The contribution of T-cell anergy to peripheral T-cell tolerance. Immunology, 103, 262 269.
    • (2001) Immunology , vol.103 , pp. 262-269
    • Lechler, R.1    Chai, J.G.2    Marelli-Berg, F.3    Lombardi, G.4
  • 36
    • 27244442560 scopus 로고    scopus 로고
    • Noncommunicating spinal extradural arachnoid cyst causing spinal cord compression in a child
    • Liu, J.K., Cole, C.D., Sherr, G.T., Kestle, J.R. Walker, M.L. (2005) Noncommunicating spinal extradural arachnoid cyst causing spinal cord compression in a child. J. Neurosurg, 103, 266 269.
    • (2005) J. Neurosurg , vol.103 , pp. 266-269
    • Liu, J.K.1    Cole, C.D.2    Sherr, G.T.3    Kestle, J.R.4    Walker, M.L.5
  • 38
    • 27144540518 scopus 로고    scopus 로고
    • Spinal cord impingement by a displaced rib in scoliosis due to neurofibromatosis
    • Mukhtar, I.A., Letts, M. Kontio, K. (2005) Spinal cord impingement by a displaced rib in scoliosis due to neurofibromatosis. Can. J. Surg., 48, 414 415.
    • (2005) Can. J. Surg. , vol.48 , pp. 414-415
    • Mukhtar, I.A.1    Letts, M.2    Kontio, K.3
  • 39
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: A review with an emphasis on the implications for white matter degeneration
    • Park, E., Velumian, A.A. Fehlings, M.G. (2004) The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J. Neurotrauma, 21, 754 774.
    • (2004) J. Neurotrauma , vol.21 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 40
    • 0037216605 scopus 로고    scopus 로고
    • Manipulating neuroinflammatory reactions in the injured spinal cord: Back to basics
    • Popovich, P.G. Jones, T.B. (2003) Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics. Trends Pharmacol. Sci., 24, 13 17.
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 13-17
    • Popovich, P.G.1    Jones, T.B.2
  • 42
    • 17444370950 scopus 로고    scopus 로고
    • High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients
    • Qian, T., Guo, X., Levi, A.D., Vanni, S., Shebert, R.T. Sipski, M.L. (2005) High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients. Spinal Cord., 43, 199 203.
    • (2005) Spinal Cord. , vol.43 , pp. 199-203
    • Qian, T.1    Guo, X.2    Levi, A.D.3    Vanni, S.4    Shebert, R.T.5    Sipski, M.L.6
  • 44
    • 3242775428 scopus 로고    scopus 로고
    • A common vaccine for fighting neurodegenerative disorders: Recharging immunity for homeostasis
    • Schwartz, M. Kipnis, J. (2004) A common vaccine for fighting neurodegenerative disorders: recharging immunity for homeostasis. Trends Pharmacol. Sci., 25, 407 412.
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 407-412
    • Schwartz, M.1    Kipnis, J.2
  • 45
    • 0033168727 scopus 로고    scopus 로고
    • Innate and adaptive immune responses can be beneficial for CNS repair
    • Schwartz, M., Moalem, G., Leibowitz-Amit, R. Cohen, I.R. (1999) Innate and adaptive immune responses can be beneficial for CNS repair. Trends Neurosci., 22, 295 299.
    • (1999) Trends Neurosci. , vol.22 , pp. 295-299
    • Schwartz, M.1    Moalem, G.2    Leibowitz-Amit, R.3    Cohen, I.R.4
  • 46
    • 0347993168 scopus 로고    scopus 로고
    • Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system
    • Shaked, I., Porat, Z., Gersner, R., Kipnis, J. Schwartz, M. (2004) Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system. J. Neuroimmunol., 146, 84 93.
    • (2004) J. Neuroimmunol. , vol.146 , pp. 84-93
    • Shaked, I.1    Porat, Z.2    Gersner, R.3    Kipnis, J.4    Schwartz, M.5
  • 47
    • 14844309321 scopus 로고    scopus 로고
    • Protective autoimmunity: Interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators
    • Shaked, I., Tchoresh, D., Gersner, R., Meiri, G., Mordechai, S., Xiao, X., Hart, R.P. Schwartz, M. (2005) Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators. J. Neurochem., 92, 997 1009.
    • (2005) J. Neurochem. , vol.92 , pp. 997-1009
    • Shaked, I.1    Tchoresh, D.2    Gersner, R.3    Meiri, G.4    Mordechai, S.5    Xiao, X.6    Hart, R.P.7    Schwartz, M.8
  • 48
    • 0028674139 scopus 로고
    • Interleukin-1 beta converting enzyme
    • Thornberry, N.A. (1994) Interleukin-1 beta converting enzyme. Meth. Enzymol., 244, 615 631.
    • (1994) Meth. Enzymol. , vol.244 , pp. 615-631
    • Thornberry, N.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.