Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-κB signaling in cultured astrocytes

Toxicology and Applied Pharmacology

Volumn 238, Issue 1, 2009, Pages 56-63

  Kakita, Hiroki ^a,b   Aoyama, Mineyoshi ^a   Hussein, Mohamed Hamed ^a,c,d   Kato, Shin ^a   Suzuki, Satoshi ^a   Ito, Tetsuya ^a   Togari, Hajime ^a   Asai, Kiyofumi ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^c CAIRO UNIVERSITY   (Egypt)

^d VACSERA   (Egypt)

Author keywords

Astrocyte; Diclofenac (DCF); Inducible nitric oxide synthase (iNOS); Influenza associated encephalopathy; nitric oxide (NO); Nuclear factor kappa B (NF B); Proinflammatory cytokines

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYTOKINE; DICLOFENAC; GAMMA INTERFERON; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITOR; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; N(G) METHYLARGININE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; SMALL INTERFERING RNA; SN 50; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENE EXPRESSION REGULATION; INFLUENZA VIRUS; INOS GENE; MORTALITY; NONHUMAN; RAT; VIRUS ENCEPHALITIS;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTROCYTES; CELLS, CULTURED; DICLOFENAC; ENCEPHALITIS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERFERON-GAMMA; INTERLEUKIN-1BETA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

ORTHOMYXOVIRIDAE; RATTUS;

EID: 67349128316     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.04.014     Document Type: Article

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