메뉴 건너뛰기




Volumn 5, Issue 1, 2012, Pages 95-106

A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; ONCOPROTEIN; PROTEIN P53; RNA BINDING PROTEIN EWS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FLI1; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84855893656     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.007401     Document Type: Article
Times cited : (62)

References (60)
  • 6
    • 33747884345 scopus 로고    scopus 로고
    • [19] Gene Expression Omnibus: Microarray Data Storage, Submission, Retrieval, and Analysis
    • DOI 10.1016/S0076-6879(06)11019-8, PII S0076687906110198, DNA Microarrays, Part B: Databases and Statistics
    • Barrett, T. and Edgar, R. (2006). Gene expression omnibus: microarray data storage, submission, retrieval, and analysis. Methods Enzymol. 411, 352-369. (Pubitemid 44291435)
    • (2006) Methods in Enzymology , vol.411 , pp. 352-369
    • Barrett, T.1    Edgar, R.2
  • 10
    • 37249020010 scopus 로고    scopus 로고
    • Novel markers of subclinical disease for Ewing family tumors from gene expression profiling
    • DOI 10.1158/1078-0432.CCR-07-1417
    • Cheung, I. Y., Feng, Y., Danis, K., Shukla, N., Meyers, P., Ladanyi, M. and Cheung, N. K. (2007). Novel markers of subclinical disease for Ewing family tumors from gene expression profiling. Clin. Cancer Res. 13, 6978-6983. (Pubitemid 350276878)
    • (2007) Clinical Cancer Research , vol.13 , Issue.23 , pp. 6978-6983
    • Cheung, I.Y.1    Feng, Y.2    Danis, K.3    Shukla, N.4    Meyers, P.5    Ladanyi, M.6    Cheung, N.-K.V.7
  • 11
    • 0034968428 scopus 로고    scopus 로고
    • KIP2 and c-Myc expression
    • DOI 10.1038/sj.onc.1204437
    • Dauphinot, L., De Oliveira, C., Melot, T., Sevenet, N., Thomas, V., Weissman, B. E. and Delattre, O. (2001). Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression. Oncogene 20, 3258-3265. (Pubitemid 32553678)
    • (2001) Oncogene , vol.20 , Issue.25 , pp. 3258-3265
    • Dauphinot, L.1    De Oliveira, C.2    Melot, T.3    Sevenet, N.4    Thomas, V.5    Weissman, B.E.6    Delattre, O.7
  • 13
    • 0035845859 scopus 로고    scopus 로고
    • Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation
    • DOI 10.1038/sj.onc.1204875
    • Deneen, B. and Denny, C. T. (2001). Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene 20, 6731-6741. (Pubitemid 33020602)
    • (2001) Oncogene , vol.20 , Issue.46 , pp. 6731-6741
    • Deneen, B.1    Denny, C.T.2
  • 14
    • 70350450778 scopus 로고    scopus 로고
    • Perspectives on the development of imatinib and the future of cancer research
    • Druker, B. J. (2009). Perspectives on the development of imatinib and the future of cancer research. Nat. Med. 15, 1149-1152.
    • (2009) Nat. Med. , vol.15 , pp. 1149-1152
    • Druker, B.J.1
  • 15
    • 66249118406 scopus 로고    scopus 로고
    • Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines
    • Embree, L. J., Azuma, M. and Hickstein, D. D. (2009). Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines. Cancer Res. 69, 4363-4371.
    • (2009) Cancer Res. , vol.69 , pp. 4363-4371
    • Embree, L.J.1    Azuma, M.2    Hickstein, D.D.3
  • 18
    • 0028179992 scopus 로고
    • p53 mutations in human tumors with chimeric EWS/FLI-1 genes
    • Hamelin, R., Zucman, J., Melot, T., Delattre, O. and Thomas, G. (1994). p53 mutations in human tumors with chimeric EWS/FLI-1 genes. Int. J. Cancer 57, 336-340.
    • (1994) Int. J. Cancer , vol.57 , pp. 336-340
    • Hamelin, R.1    Zucman, J.2    Melot, T.3    Delattre, O.4    Thomas, G.5
  • 19
    • 40549086265 scopus 로고    scopus 로고
    • A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature
    • Hancock, J. D. and Lessnick, S. L. (2008). A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle 7, 250-256. (Pubitemid 351366526)
    • (2008) Cell Cycle , vol.7 , Issue.2 , pp. 250-256
    • Hancock, J.D.1    Lessnick, S.L.2
  • 21
    • 19644386697 scopus 로고    scopus 로고
    • EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors
    • DOI 10.1158/0008-5472.CAN-04-2857
    • Hu-Lieskovan, S., Zhang, J., Wu, L., Shimada, H., Schofield, D. E. and Triche, T. J. (2005). EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 65, 4633-4644. (Pubitemid 40740799)
    • (2005) Cancer Research , vol.65 , Issue.11 , pp. 4633-4644
    • Hu-Lieskovan, S.1    Zhang, J.2    Wu, L.3    Shimada, H.4    Schofield, D.E.5    Triche, T.J.6
  • 22
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, da W., Sherman, B. T. and Lempicki, R. A. (2009a). Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57.
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 23
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang, da W., Sherman, B. T. and Lempicki, R. A. (2009b). Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1-13.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 25
    • 0028200915 scopus 로고
    • An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation
    • Ichikawa, H., Shimizu, K., Hayashi, Y. and Ohki, M. (1994). An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res. 54, 2865-2868. (Pubitemid 24187764)
    • (1994) Cancer Research , vol.54 , Issue.11 , pp. 2865-2868
    • Ichikawa, H.1    Shimizu, K.2    Hayashi, Y.3    Ohki, M.4
  • 26
    • 77649162335 scopus 로고    scopus 로고
    • Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma
    • Jakovljevic, G., Nakic, M., Rogosic, S., Kardum-Skelin, I., Mrsic-Davidovic, S., Zadro, R. and Kruslin, B. (2010). Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma. Pediatr. Blood Cancer 54, 606-609.
    • (2010) Pediatr. Blood Cancer , vol.54 , pp. 606-609
    • Jakovljevic, G.1    Nakic, M.2    Rogosic, S.3    Kardum-Skelin, I.4    Mrsic-Davidovic, S.5    Zadro, R.6    Kruslin, B.7
  • 28
    • 4344636300 scopus 로고    scopus 로고
    • A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish
    • DOI 10.1016/j.devcel.2004.06.005, PII S1534580704002059
    • Kawakami, K., Takeda, H., Kawakami, N., Kobayashi, M., Matsuda, N. and Mishina, M. (2004). A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Dev. Cell 7, 133-144. (Pubitemid 39172695)
    • (2004) Developmental Cell , vol.7 , Issue.1 , pp. 133-144
    • Kawakami, K.1    Takeda, H.2    Kawakami, N.3    Kobayashi, M.4    Matsuda, N.5    Mishina, M.6
  • 33
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • DOI 10.1016/S1535-6108(02)00056-9
    • Lessnick, S. L., Dacwag, C. S. and Golub, T. R. (2002). The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 1, 393-401. (Pubitemid 41039140)
    • (2002) Cancer Cell , vol.1 , Issue.4 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 34
  • 35
    • 55349094311 scopus 로고    scopus 로고
    • EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model
    • Lin, P. P., Pandey, M. K., Jin, F., Xiong, S., Deavers, M., Parant, J. M. and Lozano, G. (2008). EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res. 68, 8968-8975.
    • (2008) Cancer Res. , vol.68 , pp. 8968-8975
    • Lin, P.P.1    Pandey, M.K.2    Jin, F.3    Xiong, S.4    Deavers, M.5    Parant, J.M.6    Lozano, G.7
  • 36
    • 33947581390 scopus 로고    scopus 로고
    • The impact of translocations and gene fusions on cancer causation
    • DOI 10.1038/nrc2091, PII NRC2091
    • Mitelman, F., Johansson, B. and Mertens, F. (2007). The impact of translocations and gene fusions on cancer causation. Nat. Rev. Cancer 7, 233-245. (Pubitemid 46480968)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.4 , pp. 233-245
    • Mitelman, F.1    Johansson, B.2    Mertens, F.3
  • 41
    • 44849085869 scopus 로고    scopus 로고
    • EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma
    • Owen, L. A., Kowalewski, A. A. and Lessnick, S. L. (2008). EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS One 3, e1965.
    • (2008) PLoS One , vol.3
    • Owen, L.A.1    Kowalewski, A.A.2    Lessnick, S.L.3
  • 45
    • 70449115555 scopus 로고    scopus 로고
    • Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway
    • Roszko, I., Sawada, A. and Solnica-Krezel, L. (2009). Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Semin. Cell Dev. Biol. 20, 986-997.
    • (2009) Semin. Cell Dev. Biol. , vol.20 , pp. 986-997
    • Roszko, I.1    Sawada, A.2    Solnica-Krezel, L.3
  • 46
    • 27144541524 scopus 로고    scopus 로고
    • In vitro expansion of human mesenchymal stem cells: Choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability
    • DOI 10.1634/stemcells.2005-0094
    • Shahdadfar, A., Fronsdal, K., Haug, T., Reinholt, F. P. and Brinchmann, J. E. (2005). In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability. Stem Cells 23, 1357-1366. (Pubitemid 41504923)
    • (2005) Stem Cells , vol.23 , Issue.9 , pp. 1357-1366
    • Shahdadfar, A.1    Fronsdal, K.2    Haug, T.3    Reinholt, F.P.4    Brinchmann, J.E.5
  • 48
    • 33646366123 scopus 로고    scopus 로고
    • Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
    • DOI 10.1016/j.ccr.2006.04.004, PII S1535610806001140
    • Smith, R., Owen, L. A., Trem, D. J., Wong, J. S., Whangbo, J. S., Golub, T. R. and Lessnick, S. L. (2006). Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 9, 405-416. (Pubitemid 43668735)
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 405-416
    • Smith, R.1    Owen, L.A.2    Trem, D.J.3    Wong, J.S.4    Whangbo, J.S.5    Golub, T.R.6    Lessnick, S.L.7
  • 50
    • 8544237013 scopus 로고    scopus 로고
    • DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets
    • DOI 10.1158/0008-5472.CAN-03-4059
    • Staege, M. S., Hutter, C., Neumann, I., Foja, S., Hattenhorst, U. E., Hansen, G., Afar, D. and Burdach, S. E. (2004). DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. Cancer Res. 64, 8213-8221. (Pubitemid 39491758)
    • (2004) Cancer Research , vol.64 , Issue.22 , pp. 8213-8221
    • Staege, M.S.1    Hutter, C.2    Neumann, I.3    Foja, S.4    Hattenhorst, U.E.5    Hansen, G.6    Afar, D.7    Burdach, S.E.G.8
  • 52
    • 74049133918 scopus 로고    scopus 로고
    • Zebrafish tumor assays: The state of transplantation
    • Taylor, A. M. and Zon, L. I. (2009). Zebrafish tumor assays: the state of transplantation. Zebrafish 6, 339-346.
    • (2009) Zebrafish , vol.6 , pp. 339-346
    • Taylor, A.M.1    Zon, L.I.2
  • 53
    • 38149126474 scopus 로고    scopus 로고
    • High-resolution in situ hybridization to whole-mount zebrafish embryos
    • Thisse, C. and Thisse, B. (2008). High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat. Protoc. 3, 59-69.
    • (2008) Nat. Protoc. , vol.3 , pp. 59-69
    • Thisse, C.1    Thisse, B.2
  • 54
    • 34247570879 scopus 로고    scopus 로고
    • Mesenchymal Stem Cell Features of Ewing Tumors
    • DOI 10.1016/j.ccr.2007.02.027, PII S1535610807000888
    • Tirode, F., Laud-Duval, K., Prieur, A., Delorme, B., Charbord, P. and Delattre, O. (2007). Mesenchymal stem cell features of Ewing tumors. Cancer Cell 11, 421-429. (Pubitemid 46680428)
    • (2007) Cancer Cell , vol.11 , Issue.5 , pp. 421-429
    • Tirode, F.1    Laud-Duval, K.2    Prieur, A.3    Delorme, B.4    Charbord, P.5    Delattre, O.6
  • 56
    • 36048942033 scopus 로고    scopus 로고
    • EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice
    • DOI 10.1128/MCB.00099-07
    • Torchia, E. C., Boyd, K., Rehg, J. E., Qu, C. and Baker, S. J. (2007). EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol. Cell. Biol. 27, 7918-7934. (Pubitemid 350086425)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.22 , pp. 7918-7934
    • Torchia, E.C.1    Boyd, K.2    Rehg, J.E.3    Qu, C.4    Baker, S.J.5
  • 57
    • 33744502102 scopus 로고    scopus 로고
    • Ewing's sarcoma oncoprotein EWS-FLI1: The perfect target without a therapeutic agent
    • Uren, A. and Toretsky, J. A. (2005). Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent. Future Oncol. 1, 521-528.
    • (2005) Future Oncol. , vol.1 , pp. 521-528
    • Uren, A.1    Toretsky, J.A.2
  • 58
    • 79955600598 scopus 로고    scopus 로고
    • Analysis of cell proliferation, senescence, and cell death in zebrafish embryos
    • Verduzco, D. and Amatruda, J. F. (2011). Analysis of cell proliferation, senescence, and cell death in zebrafish embryos. Methods Cell Biol. 101, 19-38.
    • (2011) Methods Cell Biol. , vol.101 , pp. 19-38
    • Verduzco, D.1    Amatruda, J.F.2
  • 60
    • 44349145643 scopus 로고    scopus 로고
    • The EWS/FLI1 oncogenic transcription factor deregulates GLI1
    • DOI 10.1038/sj.onc.1210991, PII 1210991
    • Zwerner, J. P., Joo, J., Warner, K. L., Christensen, L., Hu-Lieskovan, S., Triche, T. J. and May, W. A. (2008). The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene 27, 3282-3291. (Pubitemid 351733391)
    • (2008) Oncogene , vol.27 , Issue.23 , pp. 3282-3291
    • Zwerner, J.P.1    Joo, J.2    Warner, K.L.3    Christensen, L.4    Hu-Lieskovan, S.5    Triche, T.J.6    May, W.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.