Application of high-frequency rheology measurements for analyzing protein-protein interactions in high protein concentration solutions using a model monoclonal antibody (IgG2)

Journal of Pharmaceutical Sciences

Volumn 95, Issue 9, 2006, Pages 1967-1983

  Saluja, Atul ^a   Badkar, Advait V ^b   Zeng, David L ^b   Nema, Sandeep ^b   Kalonia, Devendra S ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

complex viscosity; High protein concentration solutions; IgG2; Monoclonal antibody; Protein; Protein formulation; Protein protein interactions; Stability; Storage modulus; Ultrasonic shear rheometer

Indexed keywords

IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IMMUNOGLOBULIN G2; MONOMER; UNCLASSIFIED DRUG;

ARTICLE; FLOW KINETICS; HYDROPHOBICITY; IONIC STRENGTH; LIGHT SCATTERING; PH; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SHEAR RATE; VISCOELASTICITY; VISCOSITY; ZETA POTENTIAL;

EID: 33748937041     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20663     Document Type: Article

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