Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies

Pharmaceutical Research

Volumn 28, Issue 7, 2011, Pages 1750-1764

  Yadav, Sandeep ^a,b   Sreedhara, Alavattam ^b   Kanai, Sonoko ^c   Liu, Jun ^b   Lien, Samantha ^b   Lowman, Henry ^d   Kalonia, Devendra S ^a   Shire, Steven J ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b GENENTECH INC   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d CytomX Therapeutics Inc   (United States)

Author keywords

high concentration protein solution; intermolecular interactions; protein viscosity rheology; self association

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1; MONOCLONAL ANTIBODY 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONCENTRATION RESPONSE; DRUG FORMULATION; ELECTROPHORESIS; ELECTROPHORETIC MOBILITY; LIGHT SCATTERING; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SEDIMENTATION; VISCOELASTICITY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CIRCULAR DICHROISM; GLYCOSYLATION; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUTATION; VISCOELASTIC SUBSTANCES;

EID: 79959871746     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0410-0     Document Type: Article

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