Protein-solute interactions affect the outcome of ultrafiltration/ diafiltration operations

Journal of Pharmaceutical Sciences

Volumn 93, Issue 9, 2004, Pages 2332-2342

  Stoner, Michael R ^a   Fischer, Norm ^b   Nixon, Lori ^b   Buckel, Scott ^b   Benke, Mark ^b   Austin, Fred ^b   Randolph, Theodore W ^a   Kendrick, Brent S ^b  

^a University of Colorado   (United States)

^b AMGEN INC   (United States)

Author keywords

Biotechnology; Excipients; Protein formulation; Thermodynamics; Unit operations

Indexed keywords

ACETIC ACID; AMG 719; BUFFER; CERTOLIZUMAB PEGOL; CHLORIDE; EXCIPIENT; GLYCINE; HISTIDINE; HYBRID PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOTECHNOLOGY; CONCENTRATION (PARAMETERS); DIAFILTRATION; DIALYSIS; DRUG CONJUGATION; DRUG FORMULATION; DRUG MANUFACTURE; ELECTRICITY; MOLECULAR INTERACTION; OUTCOMES RESEARCH; PROTEIN INTERACTION; PROTEIN SYNTHESIS; SOLUTE; THEORY; THERMODYNAMICS; TITRIMETRY; TREATMENT OUTCOME; ULTRAFILTRATION;

EID: 4344569316     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20145     Document Type: Article

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