Monoamine oxidase inhibition by C4-substituted phthalonitriles

Bioorganic Chemistry

Volumn 40, Issue 1, 2012, Pages 114-124

  Manley King, Clarina I ^a   Bergh, Jacobus J ^a   Petzer, Jacobus P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Benzonitrile; Molecular docking; Monoamine oxidase; Phthalimide; Phthalonitrile; Reversible inhibition

Indexed keywords

3 ( 4 BROMOBENZYLOXY)BENZONITRILE; 3 (BENZYLOXY)BENZONITRILE; 3 [[ 3 PHENYLPROP 2 EN 1 YL]OXY]BENZONITRILE; 4 ( 2 PHENYLETHOXY)PHTHALONITRILE; 4 ( 3 PHENYLPROPOXY)PHTHALONITRILE; 4 ( 4 BROMOBENZYLOXY)BENZONITRILE; 4 ( 4 BROMOBENZYLOXY)PHTHALONITRILE; 4 ( 4 BROMOPHENOXY)PHTHALONITRILE; 4 (BENZYLOXY)BENZONITRILE; 4 (NAPHTHALEN 2 YLOXY)PHTHALONITRILE; 4 [ 2 ( 4 BROMOPHENYL)ETHOXY]BENZONITRILE; 4 [ 2 ( 4 BROMOPHENYL)ETHOXY]PHTHALONITRINE; 4 [ 2 (BENZYLOXY)ETHOXY]BENZONITRILE; 4 [[ 3 PHENYLPROP 2 EN 1 YL]OXY]BENZONITRILE; 4 [[ 3 PHENYLPROP 2 EN 1 YL]OXY]PHTHALONITRILE; 4 BENZYLOXYPHTHALONITRILE; 4 PHENOXYPHTHALONITRILE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; BENZONITRILE; MONOAMINE OXIDASE B INHIBITOR; MONOAMINE OXIDASE INHIBITOR; NITRILE; PHTHALIC ACID DERIVATIVE; PHTHALIMIDE DERIVATIVE; PHTHALONITRILE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE; IC 50; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SUBSTITUTION REACTION;

BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME ACTIVATION; HUMANS; KINETICS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NITRILES; PHTHALIMIDES;

EID: 84855876038     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2011.10.003     Document Type: Article

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