Synthesis and binding properties of a macrocyclic peptide receptor

Chemistry - A European Journal

Volumn 5, Issue 1, 1999, Pages 79-89

  Dowden, James ^a   Edwards, Peter D ^b   Flack, Stephen S ^a   Kilburn, Jeremy D ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Host guest chemistry; Macrocycles; Peptides; Receptors; Synthetic methods

Indexed keywords

12 BENZYL 2 OXA 8,9,10,13,18 PENTAAZA 1(1,4),4(1,4),5(1,4),9(1,3) TETRABENZENACYCLOICOSAPHANE 7,11,14,17 TETRAONE; MACROCYCLIC COMPOUND; PEPTIDE; RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DIASTEREOISOMER; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; RECEPTOR BINDING; SYNTHESIS;

EID: 0032925548     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3765(19990104)5:1<79::AID-CHEM79>3.0.CO;2-W     Document Type: Article

References (57)

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6. For recent examples of synthetic receptors for amino acid and peptide derivatives, see for example: a) R. J. Pieters, J. Cuntze, M. Bonnet, F. Diederich, J. Chem. Soc., Perkin Trans. 2 1997, 1891; b) W. C. Still, Acc. Chem. Res. 1996, 29, 155; c) D. W. P. M. Löwik, S. J. E. Mulders, Y. Cheng, Y. Shao, R. M. J. Liskamp, Tetrahedron Lett. 1996, 37, 8253; d) M. Asakawa, C. L. Brown, D. Pasini, J. F. Stoddart, P. G. Wyatt, J. Org. Chem. 1996, 61, 7234; e) C. Gennari, H. P. Nestler, B. Salom, W. C. Still, Angew. Chem. 1995, 107, 1894; Angew. Chem. Int. Ed. Engl. 1995, 34, 1765; f) Y. Kuroda, Y. Kato, T. Higashioji, J. Hasegawa, S. Kawanami, M. Takahashi, N. Shiraishi, K. Tanabe, H. Ogoshi, J. Am. Chem. Soc. 1995, 117, 10950; g) S. R. LaBrenz, J. W. Kelly, J. Am. Chem. Soc. 1995, 117, 1655; h) H. J. Schneider, Angew. Chem. 1993, 105, 890; Angew. Chem. Im. Ed. Engl. 1993, 32, 848. See also references [3, 5].
7. For recent examples of synthetic receptors for amino acid and peptide derivatives, see for example: a) R. J. Pieters, J. Cuntze, M. Bonnet, F. Diederich, J. Chem. Soc., Perkin Trans. 2 1997, 1891; b) W. C. Still, Acc. Chem. Res. 1996, 29, 155; c) D. W. P. M. Löwik, S. J. E. Mulders, Y. Cheng, Y. Shao, R. M. J. Liskamp, Tetrahedron Lett. 1996, 37, 8253; d) M. Asakawa, C. L. Brown, D. Pasini, J. F. Stoddart, P. G. Wyatt, J. Org. Chem. 1996, 61, 7234; e) C. Gennari, H. P. Nestler, B. Salom, W. C. Still, Angew. Chem. 1995, 107, 1894; Angew. Chem. Int. Ed. Engl. 1995, 34, 1765; f) Y. Kuroda, Y. Kato, T. Higashioji, J. Hasegawa, S. Kawanami, M. Takahashi, N. Shiraishi, K. Tanabe, H. Ogoshi, J. Am. Chem. Soc. 1995, 117, 10950; g) S. R. LaBrenz, J. W. Kelly, J. Am. Chem. Soc. 1995, 117, 1655; h) H. J. Schneider, Angew. Chem. 1993, 105, 890; Angew. Chem. Im. Ed. Engl. 1993, 32, 848. See also references [3, 5].
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