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Volumn 590, Issue 2, 2012, Pages 241-257

Orai3 - the 'exceptional' Orai?

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; PROTEIN ORAI3; PROTEIN OREI2; UNCLASSIFIED DRUG;

EID: 84855869161     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.220574     Document Type: Review
Times cited : (75)

References (101)
  • 3
    • 0025350112 scopus 로고
    • Calcium oscillations
    • Berridge MJ (1990). Calcium oscillations. J Biol Chem 265, 9583-9586.
    • (1990) J Biol Chem , vol.265 , pp. 9583-9586
    • Berridge, M.J.1
  • 4
    • 0024219844 scopus 로고
    • Cytosolic calcium oscillators
    • Berridge MJ & Galione A (1988). Cytosolic calcium oscillators. FASEB J 2, 3074-3082.
    • (1988) FASEB J , vol.2 , pp. 3074-3082
    • Berridge, M.J.1    Galione, A.2
  • 5
    • 0036829060 scopus 로고    scopus 로고
    • Inhibition of the type 1 inositol 1,4,5-trisphosphate receptor by 2-aminoethoxydiphenylborate
    • Bilmen JG & Michelangeli F (2002). Inhibition of the type 1 inositol 1, 4, 5-trisphosphate receptor by 2-aminoethoxydiphenylborate. Cell Signal 14, 955-960.
    • (2002) Cell Signal , vol.14 , pp. 955-960
    • Bilmen, J.G.1    Michelangeli, F.2
  • 7
    • 0030019847 scopus 로고    scopus 로고
    • Extracellular calcium concentration controls the frequency of intracellular calcium spiking independently of inositol 1,4,5-trisphosphate production in HeLa cells
    • Bootman MD, Young KW, Young JM, Moreton RB & Berridge MJ (1996). Extracellular calcium concentration controls the frequency of intracellular calcium spiking independently of inositol 1, 4, 5-trisphosphate production in HeLa cells. Biochem J 314, 347-354.
    • (1996) Biochem J , vol.314 , pp. 347-354
    • Bootman, M.D.1    Young, K.W.2    Young, J.M.3    Moreton, R.B.4    Berridge, M.J.5
  • 9
    • 34247193635 scopus 로고    scopus 로고
    • 2+ channel subunit, orai
    • 2+ channel subunit, orai. J Mol Biol 368, 1284-1291.
    • (2007) J Mol Biol , vol.368 , pp. 1284-1291
    • Cai, X.1
  • 10
    • 2642568616 scopus 로고    scopus 로고
    • 2-Aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3
    • Chung MK, Lee H, Mizuno A, Suzuki M & Caterina MJ (2004). 2-Aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci 24, 5177-5182.
    • (2004) J Neurosci , vol.24 , pp. 5177-5182
    • Chung, M.K.1    Lee, H.2    Mizuno, A.3    Suzuki, M.4    Caterina, M.J.5
  • 12
    • 50349103128 scopus 로고    scopus 로고
    • Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry
    • DeHaven WI, Smyth JT, Boyles RR, Bird GS & Putney JW Jr (2008). Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem 283, 19265-19273.
    • (2008) J Biol Chem , vol.283 , pp. 19265-19273
    • DeHaven, W.I.1    Smyth, J.T.2    Boyles, R.R.3    Bird, G.S.4    Putney Jr, J.W.5
  • 13
    • 34347342283 scopus 로고    scopus 로고
    • Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels
    • DeHaven WI, Smyth JT, Boyles RR & Putney JW Jr (2007). Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels. J Biol Chem 282, 17548-17556.
    • (2007) J Biol Chem , vol.282 , pp. 17548-17556
    • DeHaven, W.I.1    Smyth, J.T.2    Boyles, R.R.3    Putney Jr, J.W.4
  • 14
    • 0032580202 scopus 로고    scopus 로고
    • Calcium oscillations increase the efficiency and specificity of gene expression
    • Dolmetsch RE, Xu KL & Lewis RS (1998). Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392, 933-936.
    • (1998) Nature , vol.392 , pp. 933-936
    • Dolmetsch, R.E.1    Xu, K.L.2    Lewis, R.S.3
  • 15
    • 78649683967 scopus 로고    scopus 로고
    • Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells
    • Faouzi M, Hague F, Potier M, Ahidouch A, Sevestre H & Ouadid-Ahidouch H (2011). Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells. J Cell Physiol 226, 542-551.
    • (2011) J Cell Physiol , vol.226 , pp. 542-551
    • Faouzi, M.1    Hague, F.2    Potier, M.3    Ahidouch, A.4    Sevestre, H.5    Ouadid-Ahidouch, H.6
  • 16
    • 70349116421 scopus 로고    scopus 로고
    • 2+ entry in the immune system and beyond
    • 2+ entry in the immune system and beyond. Immunol Rev 231, 189-209.
    • (2009) Immunol Rev , vol.231 , pp. 189-209
    • Feske, S.1
  • 18
    • 69249152563 scopus 로고    scopus 로고
    • Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant
    • Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K & Romanin C (2009). Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant. J Biol Chem 284, 21696-21706.
    • (2009) J Biol Chem , vol.284 , pp. 21696-21706
    • Frischauf, I.1    Muik, M.2    Derler, I.3    Bergsmann, J.4    Fahrner, M.5    Schindl, R.6    Groschner, K.7    Romanin, C.8
  • 19
    • 0035281595 scopus 로고    scopus 로고
    • 2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors
    • 2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors. Biochem J 354, 285-290.
    • (2001) Biochem J , vol.354 , pp. 285-290
    • Gregory, R.B.1    Rychkov, G.2    Barritt, G.J.3
  • 23
    • 0029143569 scopus 로고
    • Decoding of cytosolic calcium oscillations in the mitochondria
    • Hajnoczky G, Robb-Gaspers LD, Seitz MB & Thomas AP (1995). Decoding of cytosolic calcium oscillations in the mitochondria. Cell 82, 415-424.
    • (1995) Cell , vol.82 , pp. 415-424
    • Hajnoczky, G.1    Robb-Gaspers, L.D.2    Seitz, M.B.3    Thomas, A.P.4
  • 24
    • 77950377028 scopus 로고    scopus 로고
    • Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
    • Hogan PG, Lewis RS & Rao A (2010). Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol 28, 491-533.
    • (2010) Annu Rev Immunol , vol.28 , pp. 491-533
    • Hogan, P.G.1    Lewis, R.S.2    Rao, A.3
  • 25
    • 0026594980 scopus 로고
    • Depletion of intracellular calcium stores activates a calcium current in mast cells
    • Hoth M & Penner R (1992). Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355, 353-356.
    • (1992) Nature , vol.355 , pp. 353-356
    • Hoth, M.1    Penner, R.2
  • 26
    • 0027175061 scopus 로고
    • Calcium release-activated calcium current in rat mast cells
    • Hoth M & Penner R (1993). Calcium release-activated calcium current in rat mast cells. J Physiol 465, 359-386.
    • (1993) J Physiol , vol.465 , pp. 359-386
    • Hoth, M.1    Penner, R.2
  • 28
    • 0035669916 scopus 로고    scopus 로고
    • 2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1,4,5-trisphosphate receptors
    • Iwasaki H, Mori Y, Hara Y, Uchida K, Zhou H & Mikoshiba K (2001). 2-Aminoethoxydiphenyl borate (2-APB) inhibits capacitative calcium entry independently of the function of inositol 1, 4, 5-trisphosphate receptors. Receptors Channels 7, 429-439.
    • (2001) Receptors Channels , vol.7 , pp. 429-439
    • Iwasaki, H.1    Mori, Y.2    Hara, Y.3    Uchida, K.4    Zhou, H.5    Mikoshiba, K.6
  • 29
    • 0025283839 scopus 로고
    • Calcium oscillations in electrically non-excitable cells
    • Jacob R (1990). Calcium oscillations in electrically non-excitable cells. Biochim Biophys Acta 1052, 427-438.
    • (1990) Biochim Biophys Acta , vol.1052 , pp. 427-438
    • Jacob, R.1
  • 31
    • 35548936179 scopus 로고    scopus 로고
    • Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate
    • Juvin V, Penna A, Chemin J, Lin YL & Rassendren FA (2007). Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate. Mol Pharmacol 72, 1258-1268.
    • (2007) Mol Pharmacol , vol.72 , pp. 1258-1268
    • Juvin, V.1    Penna, A.2    Chemin, J.3    Lin, Y.L.4    Rassendren, F.A.5
  • 32
    • 0036023404 scopus 로고    scopus 로고
    • Distinct properties of CRAC and MIC channels in RBL cells
    • Kozak JA, Kerschbaum HH & Cahalan MD (2002). Distinct properties of CRAC and MIC channels in RBL cells. J Gen Physiol 120, 221-235.
    • (2002) J Gen Physiol , vol.120 , pp. 221-235
    • Kozak, J.A.1    Kerschbaum, H.H.2    Cahalan, M.D.3
  • 34
    • 0035064074 scopus 로고    scopus 로고
    • Calcium signaling mechanisms in T lymphocytes
    • Lewis RS (2001). Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol 19, 497-521.
    • (2001) Annu Rev Immunol , vol.19 , pp. 497-521
    • Lewis, R.S.1
  • 36
    • 33646140352 scopus 로고    scopus 로고
    • Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7
    • Li M, Jiang J & Yue L (2006). Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol 127, 525-537.
    • (2006) J Gen Physiol , vol.127 , pp. 525-537
    • Li, M.1    Jiang, J.2    Yue, L.3
  • 41
    • 78650070349 scopus 로고    scopus 로고
    • A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating
    • Lis A, Zierler S, Peinelt C, Fleig A & Penner R (2010). A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. J Gen Physiol 136, 673-686.
    • (2010) J Gen Physiol , vol.136 , pp. 673-686
    • Lis, A.1    Zierler, S.2    Peinelt, C.3    Fleig, A.4    Penner, R.5
  • 46
    • 67649388419 scopus 로고    scopus 로고
    • Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain
    • Maruyama Y, Ogura T, Mio K, Kato K, Kaneko T, Kiyonaka S, Mori Y & Sato C (2009). Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domain. J Biol Chem 284, 13676-13685.
    • (2009) J Biol Chem , vol.284 , pp. 13676-13685
    • Maruyama, Y.1    Ogura, T.2    Mio, K.3    Kato, K.4    Kaneko, T.5    Kiyonaka, S.6    Mori, Y.7    Sato, C.8
  • 49
    • 33747643506 scopus 로고    scopus 로고
    • Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1
    • Mercer JC, DeHaven WI, Smyth JT, Wedel B, Boyles RR, Bird GS & Putney JW Jr (2006). Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem 281, 24979-24990.
    • (2006) J Biol Chem , vol.281 , pp. 24979-24990
    • Mercer, J.C.1    DeHaven, W.I.2    Smyth, J.T.3    Wedel, B.4    Boyles, R.R.5    Bird, G.S.6    Putney Jr, J.W.7
  • 53
    • 33947144703 scopus 로고    scopus 로고
    • 2+-selective (ARC) channels without store depletion or translocation to the plasma membrane
    • 2+-selective (ARC) channels without store depletion or translocation to the plasma membrane. J Physiol 579, 703-715.
    • (2007) J Physiol , vol.579 , pp. 703-715
    • Mignen, O.1    Thompson, J.L.2    Shuttleworth, T.J.3
  • 55
    • 38149040968 scopus 로고    scopus 로고
    • Orai1 subunit stoichiometry of the mammalian CRAC channel pore
    • Mignen O, Thompson JL & Shuttleworth TJ (2008b). Orai1 subunit stoichiometry of the mammalian CRAC channel pore. J Physiol 586, 419-425.
    • (2008) J Physiol , vol.586 , pp. 419-425
    • Mignen, O.1    Thompson, J.L.2    Shuttleworth, T.J.3
  • 56
    • 69949095093 scopus 로고    scopus 로고
    • 2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits
    • 2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. J Physiol 587, 4181-4197.
    • (2009) J Physiol , vol.587 , pp. 4181-4197
    • Mignen, O.1    Thompson, J.L.2    Shuttleworth, T.J.3
  • 59
    • 77953532418 scopus 로고    scopus 로고
    • A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells
    • Motiani RK, Abdullaev IF & Trebak M (2010). A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. J Biol Chem 285, 19173-19183.
    • (2010) J Biol Chem , vol.285 , pp. 19173-19183
    • Motiani, R.K.1    Abdullaev, I.F.2    Trebak, M.3
  • 62
    • 0029739948 scopus 로고    scopus 로고
    • Identification of stromal cell products that interact with pre-B cells
    • Oritani K & Kincade PW (1996). Identification of stromal cell products that interact with pre-B cells. J Cell Biol 134, 771-782.
    • (1996) J Cell Biol , vol.134 , pp. 771-782
    • Oritani, K.1    Kincade, P.W.2
  • 64
    • 0030588129 scopus 로고    scopus 로고
    • Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5
    • Parker NJ, Begley CG, Smith PJ & Fox RM (1996). Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5. Genomics 37, 253-256.
    • (1996) Genomics , vol.37 , pp. 253-256
    • Parker, N.J.1    Begley, C.G.2    Smith, P.J.3    Fox, R.M.4
  • 65
    • 47249095816 scopus 로고    scopus 로고
    • 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
    • Peinelt C, Lis A, Beck A, Fleig A & Penner R (2008). 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J Physiol 586, 3061-3073.
    • (2008) J Physiol , vol.586 , pp. 3061-3073
    • Peinelt, C.1    Lis, A.2    Beck, A.3    Fleig, A.4    Penner, R.5
  • 67
    • 55549083129 scopus 로고    scopus 로고
    • The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
    • Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I & Cahalan MD (2008). The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature 456, 116-120.
    • (2008) Nature , vol.456 , pp. 116-120
    • Penna, A.1    Demuro, A.2    Yeromin, A.V.3    Zhang, S.L.4    Safrina, O.5    Parker, I.6    Cahalan, M.D.7
  • 68
    • 0038420824 scopus 로고    scopus 로고
    • 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels
    • Peppiatt CM, Collins TJ, Mackenzie L, Conway SJ, Holmes AB, Bootman MD, Berridge MJ, Seo JT & Roderick HL (2003). 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1, 4, 5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. Cell Calcium 34, 97-108.
    • (2003) Cell Calcium , vol.34 , pp. 97-108
    • Peppiatt, C.M.1    Collins, T.J.2    Mackenzie, L.3    Conway, S.J.4    Holmes, A.B.5    Bootman, M.D.6    Berridge, M.J.7    Seo, J.T.8    Roderick, H.L.9
  • 71
    • 0024397869 scopus 로고
    • Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes
    • Rooney TA, Sass EJ & Thomas AP (1989). Characterization of cytosolic calcium oscillations induced by phenylephrine and vasopressin in single fura-2-loaded hepatocytes. J Biol Chem 264, 17131-17141.
    • (1989) J Biol Chem , vol.264 , pp. 17131-17141
    • Rooney, T.A.1    Sass, E.J.2    Thomas, A.P.3
  • 73
    • 0030882681 scopus 로고    scopus 로고
    • GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development
    • Sabbioni S, Barbanti-Brodano G, Croce CM & Negrini M (1997). GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. Cancer Res 57, 4493-4497.
    • (1997) Cancer Res , vol.57 , pp. 4493-4497
    • Sabbioni, S.1    Barbanti-Brodano, G.2    Croce, C.M.3    Negrini, M.4
  • 76
    • 67649653747 scopus 로고    scopus 로고
    • Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins
    • Scrimgeour N, Litjens T, Ma L, Barritt GJ & Rychkov GY (2009). Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins. J Physiol 587, 2903-2918.
    • (2009) J Physiol , vol.587 , pp. 2903-2918
    • Scrimgeour, N.1    Litjens, T.2    Ma, L.3    Barritt, G.J.4    Rychkov, G.Y.5
  • 81
    • 0025753412 scopus 로고
    • Spatial and temporal organization of calcium signalling in hepatocytes
    • Thomas AP, Renard DC & Rooney TA (1991). Spatial and temporal organization of calcium signalling in hepatocytes. Cell Calcium 12, 111-126.
    • (1991) Cell Calcium , vol.12 , pp. 111-126
    • Thomas, A.P.1    Renard, D.C.2    Rooney, T.A.3
  • 82
    • 77957733927 scopus 로고    scopus 로고
    • The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid
    • Thompson JL, Mignen O & Shuttleworth TJ (2010). The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid. Channels (Austin) 4, 398-410.
    • (2010) Channels (Austin) , vol.4 , pp. 398-410
    • Thompson, J.L.1    Mignen, O.2    Shuttleworth, T.J.3
  • 83
    • 80055005736 scopus 로고    scopus 로고
    • Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations
    • Thompson JL & Shuttleworth TJ (2011). Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations. J Physiol 589, 5057-5069.
    • (2011) J Physiol , vol.589 , pp. 5057-5069
    • Thompson, J.L.1    Shuttleworth, T.J.2
  • 84
    • 0037077249 scopus 로고    scopus 로고
    • Comparison of human TRPC3 channels in receptor-activated and store-operated modes - Differential sensitivity to channel blockers suggests fundamental differences in channel composition
    • Trebak M, Bird GSJ, McKay RR & Putney JW Jr (2002). Comparison of human TRPC3 channels in receptor-activated and store-operated modes - Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J Biol Chem 277, 21617-21623.
    • (2002) J Biol Chem , vol.277 , pp. 21617-21623
    • Trebak, M.1    Bird, G.S.J.2    McKay, R.R.3    Putney Jr, J.W.4
  • 91
    • 0036537823 scopus 로고    scopus 로고
    • Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation
    • Williams RT, Senior PV, Van Stekelenburg L, Layton JE, Smith PJ & Dziadek MA (2002). Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation. Biochim Biophys Acta 1596, 131-137.
    • (2002) Biochim Biophys Acta , vol.1596 , pp. 131-137
    • Williams, R.T.1    Senior, P.V.2    Van Stekelenburg, L.3    Layton, J.E.4    Smith, P.J.5    Dziadek, M.A.6
  • 94
    • 33748655172 scopus 로고    scopus 로고
    • Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
    • Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O & Cahalan MD (2006). Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443, 226-229.
    • (2006) Nature , vol.443 , pp. 226-229
    • Yeromin, A.V.1    Zhang, S.L.2    Jiang, W.3    Yu, Y.4    Safrina, O.5    Cahalan, M.D.6
  • 101
    • 0030005990 scopus 로고    scopus 로고
    • Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes
    • Zweifach A & Lewis RS (1996). Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes. J Gen Physiol 107, 597-610.
    • (1996) J Gen Physiol , vol.107 , pp. 597-610
    • Zweifach, A.1    Lewis, R.S.2


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