Differential redox regulation of ORAI ion channels: A mechanism to tune cellular Calcium signaling

Science Signaling

Volumn 3, Issue 115, 2010, Pages

  Bogeski, Ivan ^a   Kummerow, Carsten ^a   Al Ansary, Dalia ^a   Schwarz, Eva C ^a   Koehler, Richard ^a   Kozai, Daisuke ^b   Takahashi, Nobuaki ^b   Peinelt, Christine ^a   Griesemer, Desiree ^a,c   Bozem, Monika ^a   Mori, Yasuo ^b   Hoth, Markus ^a   Niemeyer, Barbara A ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b KYOTO UNIVERSITY   (Japan)

^c Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYSTEINE; ION CHANNEL; PROTEIN ORAI; PROTEIN ORAI 3; UNCLASSIFIED DRUG; CALCIUM CHANNEL; HYDROGEN PEROXIDE; INTERLEUKIN 2; ISOPROTEIN; ORAI1 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ARTICLE; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; CELL SURVIVAL; CHEMISTRY; LEUKEMIA CELL LINE; METABOLISM; T LYMPHOCYTE;

CALCIUM CHANNELS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; HYDROGEN PEROXIDE; INTERLEUKIN-2; JURKAT CELLS; OXIDATION-REDUCTION; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; T-LYMPHOCYTES;

EID: 77953654218     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000672     Document Type: Article

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59. Acknowledgments: Research carried out for this study with human material has been approved by the local ethics committee. We are grateful to S. Kiyonaka for providing the DTNB2-Biotin and J. Soboloff for providing HEKS1 cells. We thank B. Strauß, A. Ludes, and A. Armbrüster for technical assistance. Funding: This project was funded by the Deutsche Forschungsgemeinschaft (DFG; SFB 530, project A3, and the Graduate Programs GK1326 and GK845, to M. H. and B. A. N.) and competitive research grants from the Saarland University (HOMFOR to M. H., I. B., C. P., and B. A. N.). C. P. acknowledges funding by the DFG (PE 1478/5-1). Author contributions: I. B. performed all imaging experiments. D. A., C. K., B. A. N., C. P., and I. B. performed patch-clamp experiments. D. A. and B. A. N. cloned all constructs. E. C. S. contributed qRT-PCR data. D. K., N. T., and Y. M. contributed DTNB2-Bio data. I. B. and R. K. performed glutathione and catalase measurements. M. B., I. B., and D. A. conducted proliferation and IL-2 measurements. D. G. and C. P. provided initial technical support and reagents. I. B., Y. M., M. H., and B. A. N. designed experiments, analyzed the data, and wrote the paper. Competing interests: The authors have no conflicting financial interests.